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HUMAN:PQBP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PQBP1 (synonyms: NPW38) | |
| Protein Name(s) | Polyglutamine-binding protein 1
PQBP-1 38 kDa nuclear protein containing a WW domain Npw38 Polyglutamine tract-binding protein 1 | |
| External Links | ||
| UniProt | O60828 | |
| EMBL | AJ242829 AB016533 AB041832 AB041832 AB041832 AB041832 AB041833 AB041834 AB041835 AB041836 AJ973593 AJ973594 AJ973595 AJ973596 AJ973597 AJ973598 AJ973599 AJ973600 AJ973601 AJ973602 AJ973603 AJ973605 AJ973606 AJ973607 AJ005893 BC012358 | |
| CCDS | CCDS14309.1 CCDS55412.1 | |
| RefSeq | NP_001027553.1 NP_001027554.1 NP_001027555.1 NP_001027556.1 NP_001161461.1 NP_001161462.1 NP_001161464.1 NP_005701.1 NP_652766.1 XP_005272628.1 XP_005272629.1 | |
| UniGene | Hs.534384 | |
| PDB | 4BWQ 4BWS 4CDO | |
| PDBsum | 4BWQ 4BWS 4CDO | |
| ProteinModelPortal | O60828 | |
| SMR | O60828 | |
| BioGrid | 115393 | |
| IntAct | O60828 | |
| MINT | MINT-112545 | |
| PhosphoSite | O60828 | |
| MaxQB | O60828 | |
| PaxDb | O60828 | |
| PRIDE | O60828 | |
| DNASU | 10084 | |
| Ensembl | ENST00000218224 ENST00000247140 ENST00000376563 ENST00000376566 ENST00000396763 ENST00000447146 | |
| GeneID | 10084 | |
| KEGG | hsa:10084 | |
| UCSC | uc004dle.3 uc004dlj.1 uc004dlk.3 uc004dln.3 uc010nij.3 | |
| CTD | 10084 | |
| GeneCards | GC0XP048755 | |
| HGNC | HGNC:9330 | |
| HPA | HPA001880 | |
| MIM | 300463 309500 | |
| neXtProt | NX_O60828 | |
| Orphanet | 93946 93947 93945 93950 | |
| PharmGKB | PA33693 | |
| eggNOG | NOG265480 | |
| GeneTree | ENSGT00390000001905 | |
| HOVERGEN | HBG053064 | |
| InParanoid | O60828 | |
| KO | K12865 | |
| OMA | SHEKSDR | |
| PhylomeDB | O60828 | |
| TreeFam | TF320689 | |
| SignaLink | O60828 | |
| ChiTaRS | PQBP1 | |
| GeneWiki | PQBP1 | |
| GenomeRNAi | 10084 | |
| NextBio | 38125 | |
| PMAP-CutDB | O60828 | |
| PRO | PR:O60828 | |
| Proteomes | UP000005640 | |
| Bgee | O60828 | |
| ExpressionAtlas | O60828 | |
| Genevestigator | O60828 | |
| GO | GO:0005737 GO:0010494 GO:0071598 GO:0016607 GO:0005634 GO:0003677 GO:0043021 GO:0003713 GO:0000380 GO:0031175 GO:0048814 GO:0043484 GO:0006355 GO:0006351 | |
| InterPro | IPR001202 | |
| Pfam | PF00397 | |
| SMART | SM00456 | |
| SUPFAM | SSF51045 | |
| PROSITE | PS50020 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002218 |
activation of innate immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071360 |
cellular response to exogenous dsRNA |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031175 |
neuron projection development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000380 |
alternative mRNA splicing, via spliceosome |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043484 |
regulation of RNA splicing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043021 |
ribonucleoprotein complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903508 |
positive regulation of nucleic acid-templated transcription |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0003713 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-72160 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
Reactome:R-HSA-72163 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Yoh, SM et al. (2015) PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. Cell 161 1293-1305 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Wang, Q et al. (2013) PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Genes Dev. 27 615-26 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Komuro, A et al. (1999) Npw38, a novel nuclear protein possessing a WW domain capable of activating basal transcription. Nucleic Acids Res. 27 1957-65 PubMed GONUTS page
- ↑ Imafuku, I et al. (1998) Polar amino acid-rich sequences bind to polyglutamine tracts. Biochem. Biophys. Res. Commun. 253 16-20 PubMed GONUTS page
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