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PMID:9875212

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Citation

Imafuku, I, Waragai, M, Takeuchi, S, Kanazawa, I, Kawabata, M, Mouradian, MM and Okazawa, H (1998) Polar amino acid-rich sequences bind to polyglutamine tracts. Biochem. Biophys. Res. Commun. 253:16-20

Abstract

Polyglutamine tracts are found in different proteins including transcription factors and cofactors as well as in triplet repeat disease gene products. To characterize the protein motif that binds to the polyglutamine tract, we screened a human embryonic brain cDNA library with the polyglutamine tract of Brn-2 as bait using the yeast two-hybrid method. All six isolated clones encoding polyglutamine tract binding proteins were rich in polar amino acids. Three of these clones could form polar helical structures. These observations suggest that polar amino acid-rich sequences are essential for binding to the polyglutamine tract.

Links

PubMed Online version:10.1006/bbrc.1998.9725

Keywords

Amino Acid Sequence; Amino Acids/metabolism; Cloning, Molecular; DNA, Complementary/isolation & purification; Homeodomain Proteins; Humans; Molecular Sequence Data; POU Domain Factors; Peptides/genetics; Peptides/metabolism; Protein Binding; Protein Structure, Secondary; Reading Frames; Transcription Factors/metabolism; Trinucleotide Repeats

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PQBP1

enables

GO:0003677: DNA binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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