HUMAN:KAT5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KAT5 (synonyms: HTATIP, TIP60)
Protein Name(s)	Histone acetyltransferase KAT5 60 kDa Tat-interactive protein Tip60 Histone acetyltransferase HTATIP HIV-1 Tat interactive protein Lysine acetyltransferase 5 cPLA(2)-interacting protein
External Links
UniProt	Q92993
EMBL	U74667 U40989 U67734 AY214165 AK304664 AP001266 CH471076 CH471076 BC000166 BC064912 BC093032 BC143296 BC117167
CCDS	CCDS31610.1 CCDS55771.1 CCDS8109.1 CCDS8110.1
RefSeq	NP_001193762.1 NP_006379.2 NP_874368.1 NP_874369.1
UniGene	Hs.397010
PDB	2EKO 2OU2 4QQG
PDBsum	2EKO 2OU2 4QQG
ProteinModelPortal	Q92993
SMR	Q92993
BioGrid	115779
DIP	DIP-5998N
IntAct	Q92993
MINT	MINT-94861
STRING	9606.ENSP00000340330
BindingDB	Q92993
ChEMBL	CHEMBL5750
GuidetoPHARMACOLOGY	2664
PhosphoSite	Q92993
DMDM	30923328
MaxQB	Q92993
PaxDb	Q92993
PRIDE	Q92993
DNASU	10524
Ensembl	ENST00000341318 ENST00000352980 ENST00000377046 ENST00000530446
GeneID	10524
KEGG	hsa:10524
UCSC	uc001ofi.3 uc001ofj.3 uc001ofk.3 uc010roo.2
CTD	10524
GeneCards	GC11P065479
HGNC	HGNC:5275
HPA	HPA016953
MIM	601409
neXtProt	NX_Q92993
PharmGKB	PA162392746
eggNOG	COG5027
GeneTree	ENSGT00550000074503
HOGENOM	HOG000182457
InParanoid	Q92993
KO	K11304
OMA	HDDIITR
OrthoDB	EOG7ZKS9R
PhylomeDB	Q92993
TreeFam	TF317619
Reactome	REACT_172610 REACT_200753
SignaLink	Q92993
ChiTaRS	KAT5
EvolutionaryTrace	Q92993
GeneWiki	KAT5
GenomeRNAi	10524
NextBio	39922
PRO	PR:Q92993
Proteomes	UP000005640
Bgee	Q92993
CleanEx	HS_KAT5
ExpressionAtlas	Q92993
Genevestigator	Q92993
GO	GO:0005829 GO:0035267 GO:0005730 GO:0005654 GO:0005634 GO:0048471 GO:0032777 GO:0000812 GO:0005667 GO:0050681 GO:0004402 GO:0046872 GO:0070491 GO:0003713 GO:0030521 GO:0071392 GO:0006325 GO:0006978 GO:0006302 GO:0016573 GO:0032703 GO:0000122 GO:0045892 GO:0045944 GO:0045893 GO:0043161 GO:0040008 GO:0010212 GO:0006351 GO:0016032
Gene3D	3.40.630.30
InterPro	IPR016181 IPR000953 IPR016197 IPR002717 IPR025995
Pfam	PF01853 PF11717
SMART	SM00298
SUPFAM	SSF54160 SSF55729
PROSITE	PS51726

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006950	response to stress	PMID:22448206^[1]	ECO:0000314			P		Fig 6: Tip 60 shows increase binding to concanavalin A in response to ER stress	complete CACAO 4512
	GO:0006915	apoptotic process	PMID:11416127^[2]	ECO:0000314			P		Figure 8: percentage of apototic cells increases in ad-PLIP (Tip60/KAT5 splice variant) infected cells	complete
involved_in	GO:0018394	peptidyl-lysine acetylation	PMID:30704899^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061733	peptide-lysine-N-acetyltransferase activity	PMID:30704899^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:30704899^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901985	positive regulation of protein acetylation	PMID:24012345^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q9BZS1)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24012345^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	PMID:23637611^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23637611^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071392) has_input:(UniProtKB:Q6FI00)	Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:17360565^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BZS1	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17360565^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	PMID:17360565^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17360565^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:15572661^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14966270^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15572661^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:18397884^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035267	NuA4 histone acetyltransferase complex	PMID:14966270^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035267	NuA4 histone acetyltransferase complex	PMID:10966108^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032777	Piccolo NuA4 histone acetyltransferase complex	PMID:14966270^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:15572661^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	PMID:10966108^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:18397884^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PMID:14966270^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:10966108^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:16387653^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17996965^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:17996965^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:18397884^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0004402	histone acetyltransferase activity	PMID:14966270^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:14966270^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000812	Swr1 complex	PMID:24463511^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028387 MGI:MGI:1932051 PANTHER:PTN000064894 RGD:1566399 RGD:621061 UniProtKB:O95251 UniProtKB:Q92993	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0087008 PANTHER:PTN000064894 UniProtKB:Q8WYB5 UniProtKB:Q92794 UniProtKB:Q92993 UniProtKB:Q96T23 UniProtKB:Q9H7Z6 WB:WBGene00007029	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000064894 UniProtKB:Q96T23	F		Seeded From UniProt	complete
part_of	GO:0032777	Piccolo NuA4 histone acetyltransferase complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000065044 SGD:S000005770 UniProtKB:Q92993	C		Seeded From UniProt	complete
enables	GO:0010485	H4 histone acetyltransferase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028387 PANTHER:PTN002239249 SGD:S000005770	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014340 FB:FBgn0026080 FB:FBgn0026577 FB:FBgn0028387 FB:FBgn0087008 MGI:MGI:109529 MGI:MGI:2442415 PANTHER:PTN000064894 RGD:1304892 RGD:1566399 RGD:621061 TAIR:locus:2144776 TAIR:locus:2144841 TAIR:locus:2169779 TAIR:locus:2174764 UniProtKB:O95251 UniProtKB:Q6ZJM9 UniProtKB:Q8III2 UniProtKB:Q8WUB8 UniProtKB:Q92794 UniProtKB:Q92993 UniProtKB:Q96T23 UniProtKB:Q9H7Z6	C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014340 FB:FBgn0026080 MGI:MGI:1858746 PANTHER:PTN000064894 SGD:S000000148 SGD:S000004734 SGD:S000005770 TAIR:locus:2144776 TAIR:locus:2174764 UniProtKB:Q8III2 UniProtKB:Q8WYB5 UniProtKB:Q92794 UniProtKB:Q92993 UniProtKB:Q9H7Z6 ZFIN:ZDB-GENE-021022-3	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000064894 PomBase:SPAC17G8.13c RGD:621061 SGD:S000004734 SGD:S000005770 ZFIN:ZDB-GENE-021022-3	C		Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026080 PANTHER:PTN000064894 UniProtKB:O95251 UniProtKB:Q9H7Z6	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043967	histone H4 acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0010485	P		Seeded From UniProt	complete
enables	GO:0061733	peptide-lysine-N-acetyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CHK4 ensembl:ENSMUSP00000109271	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CHK4 ensembl:ENSMUSP00000109271	P		Seeded From UniProt	complete
involved_in	GO:0018394	peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CHK4 ensembl:ENSMUSP00000109271	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CHK4 ensembl:ENSMUSP00000109271	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CHK4 ensembl:ENSMUSP00000109271	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CHK4 ensembl:ENSMUSP00000109271	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CHK4 ensembl:ENSMUSP00000109271	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002717 InterPro:IPR037995	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002717	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002717 InterPro:IPR037995	P		Seeded From UniProt	complete
part_of	GO:0035267	NuA4 histone acetyltransferase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037995	C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.48	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17360565^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904837	beta-catenin-TCF complex assembly	Reactome:R-HSA-201722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016407	acetyltransferase activity	Reactome:R-HSA-6792712 Reactome:R-HSA-5682044	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-5684875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-4551334 Reactome:R-HSA-9023860 Reactome:R-HSA-69891 Reactome:R-HSA-6799332 Reactome:R-HSA-6792712 Reactome:R-HSA-5693620 Reactome:R-HSA-5693612 Reactome:R-HSA-5693608 Reactome:R-HSA-5693602 Reactome:R-HSA-5693599 Reactome:R-HSA-5693598 Reactome:R-HSA-5693593 Reactome:R-HSA-5693589 Reactome:R-HSA-5693584 Reactome:R-HSA-5693583 Reactome:R-HSA-5693580 Reactome:R-HSA-5693566 Reactome:R-HSA-5693564 Reactome:R-HSA-5693561 Reactome:R-HSA-5693551 Reactome:R-HSA-5693549 Reactome:R-HSA-5693542 Reactome:R-HSA-5693540 Reactome:R-HSA-5693539 Reactome:R-HSA-5693536 Reactome:R-HSA-5686900 Reactome:R-HSA-5686704 Reactome:R-HSA-5686685 Reactome:R-HSA-5686657 Reactome:R-HSA-5686642 Reactome:R-HSA-5686483 Reactome:R-HSA-5686469 Reactome:R-HSA-5686440 Reactome:R-HSA-5686410 Reactome:R-HSA-5685994 Reactome:R-HSA-5685985 Reactome:R-HSA-5685838 Reactome:R-HSA-5685341 Reactome:R-HSA-5685156 Reactome:R-HSA-5685011 Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-5684875 Reactome:R-HSA-5684140 Reactome:R-HSA-5684108 Reactome:R-HSA-5684096 Reactome:R-HSA-5684081 Reactome:R-HSA-5684071 Reactome:R-HSA-5684052 Reactome:R-HSA-5683986 Reactome:R-HSA-5683967 Reactome:R-HSA-5683964 Reactome:R-HSA-5683801 Reactome:R-HSA-5683735 Reactome:R-HSA-5683425 Reactome:R-HSA-5683405 Reactome:R-HSA-5683385 Reactome:R-HSA-5683384 Reactome:R-HSA-5683077 Reactome:R-HSA-5682992 Reactome:R-HSA-5682983 Reactome:R-HSA-5682967 Reactome:R-HSA-5682965 Reactome:R-HSA-5682863 Reactome:R-HSA-5682858 Reactome:R-HSA-5682629 Reactome:R-HSA-5682607 Reactome:R-HSA-5682598 Reactome:R-HSA-5682588 Reactome:R-HSA-5682586 Reactome:R-HSA-5682044 Reactome:R-HSA-5682026 Reactome:R-HSA-5682018 Reactome:R-HSA-3451153	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	Reactome:R-HSA-5693608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lee, EJ et al. (2012) Endoplasmic Reticulum (ER) Stress Enhances Tip60 (A Histone Acetyltransferase) Binding to the Concanavalin A. Open Biochem J 6 1-10 PubMed GONUTS page
↑ Sheridan, AM et al. (2001) PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Mol. Cell. Biol. 21 4470-81 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Cheng, X et al. (2019) Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol. Cell 73 788-802.e7 PubMed GONUTS page
↑ ^4.0 ^4.1 Xiao, J et al. (2013) PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses. J. Autoimmun. 47 34-44 PubMed GONUTS page
↑ ^5.0 ^5.1 Dalvai, M et al. (2013) TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription. PLoS Genet. 9 e1003387 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Li, B et al. (2007) FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. U.S.A. 104 4571-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Doyon, Y et al. (2004) Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 24 1884-96 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bhoumik, A et al. (2008) Regulation of TIP60 by ATF2 modulates ATM activation. J. Biol. Chem. 283 17605-14 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Ikura, T et al. (2000) Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102 463-73 PubMed GONUTS page
↑ Doyon, Y et al. (2006) ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol. Cell 21 51-64 PubMed GONUTS page
↑ ^12.0 ^12.1 Wang, J et al. (2008) The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. Biochim. Biophys. Acta 1783 224-36 PubMed GONUTS page
↑ Obri, A et al. (2014) ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature 505 648-53 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22448206-1] Lee, EJ et al. (2012) Endoplasmic Reticulum (ER) Stress Enhances Tip60 (A Histone Acetyltransferase) Binding to the Concanavalin A. Open Biochem J 6 1-10 PubMed GONUTS page

[PMID:11416127-2] Sheridan, AM et al. (2001) PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Mol. Cell. Biol. 21 4470-81 PubMed GONUTS page

[PMID:30704899-3] 3.0 ^3.1 ^3.2 Cheng, X et al. (2019) Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol. Cell 73 788-802.e7 PubMed GONUTS page

[PMID:24012345-4] 4.0 ^4.1 Xiao, J et al. (2013) PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses. J. Autoimmun. 47 34-44 PubMed GONUTS page

[PMID:23637611-5] 5.0 ^5.1 Dalvai, M et al. (2013) TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription. PLoS Genet. 9 e1003387 PubMed GONUTS page

[PMID:17360565-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Li, B et al. (2007) FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. U.S.A. 104 4571-6 PubMed GONUTS page

[PMID:15572661-7] 7.0 ^7.1 ^7.2 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page

[PMID:14966270-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Doyon, Y et al. (2004) Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 24 1884-96 PubMed GONUTS page

[PMID:18397884-9] 9.0 ^9.1 ^9.2 Bhoumik, A et al. (2008) Regulation of TIP60 by ATF2 modulates ATM activation. J. Biol. Chem. 283 17605-14 PubMed GONUTS page

[PMID:10966108-10] 10.0 ^10.1 ^10.2 Ikura, T et al. (2000) Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102 463-73 PubMed GONUTS page

[PMID:16387653-11] Doyon, Y et al. (2006) ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol. Cell 21 51-64 PubMed GONUTS page

[PMID:17996965-12] 12.0 ^12.1 Wang, J et al. (2008) The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. Biochim. Biophys. Acta 1783 224-36 PubMed GONUTS page

[PMID:24463511-13] Obri, A et al. (2014) ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature 505 648-53 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:KAT5

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