HUMAN:TFE2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TCF3 (synonyms: BHLHB21, E2A, ITF1)
Protein Name(s)	Transcription factor E2-alpha Class B basic helix-loop-helix protein 21 bHLHb21 Immunoglobulin enhancer-binding factor E12/E47 Immunoglobulin transcription factor 1 Kappa-E2-binding factor Transcription factor 3 TCF-3 Transcription factor ITF-1
External Links
UniProt	P15923
EMBL	M31523 M31522 M31222 AC006274 AC005321 KC877695 BC110579 BC110580 M24404 M24405 X52078 M65214
CCDS	CCDS12074.1 CCDS45899.1
PIR	A34734 S10099
RefSeq	NP_001129611.1 NP_003191.1
UniGene	Hs.371282 Hs.657044
PDB	1HLH 2MH0 2YPA 2YPB 3U5V
PDBsum	1HLH 2MH0 2YPA 2YPB 3U5V
ProteinModelPortal	P15923
SMR	P15923
BioGrid	112791
DIP	DIP-74N
IntAct	P15923
MINT	MINT-190187
STRING	9606.ENSP00000262965
PhosphoSite	P15923
DMDM	135655
MaxQB	P15923
PaxDb	P15923
PRIDE	P15923
Ensembl	ENST00000262965 ENST00000588136 ENST00000611869
GeneID	6929
KEGG	hsa:6929
UCSC	uc002lto.3 uc002lts.1
CTD	6929
GeneCards	GC19M001609
HGNC	HGNC:11633
HPA	CAB018351 HPA049808
MIM	147141
neXtProt	NX_P15923
Orphanet	33110 99860
PharmGKB	PA164742580
eggNOG	NOG282899
GeneTree	ENSGT00510000046438
HOVERGEN	HBG003854
InParanoid	P15923
KO	K09063
OrthoDB	EOG72G16Q
PhylomeDB	P15923
TreeFam	TF321672
Reactome	REACT_21402
SignaLink	P15923
ChiTaRS	TCF3
GeneWiki	TCF3
GenomeRNAi	6929
NextBio	27113
PRO	PR:P15923
Proteomes	UP000005640
Bgee	P15923
CleanEx	HS_TCF3
ExpressionAtlas	P15923
Genevestigator	P15923
GO	GO:0005737 GO:0000790 GO:0000788 GO:0005654 GO:0005634 GO:0043234 GO:0090575 GO:0005667 GO:0043425 GO:0003682 GO:0003677 GO:0070888 GO:0035326 GO:0031435 GO:0046982 GO:0042803 GO:0070491 GO:0000978 GO:0001078 GO:0003700 GO:0003713 GO:0008134 GO:0070644 GO:0030183 GO:0002326 GO:0048468 GO:0043966 GO:0043967 GO:0033152 GO:0042692 GO:0001779 GO:0000122 GO:0048541 GO:0030890 GO:0045787 GO:0051149 GO:0045666 GO:0051091 GO:0045944 GO:0045893 GO:0050821 GO:2000045 GO:0006355 GO:0042493 GO:0032496 GO:0033077 GO:0006351
Gene3D	4.10.280.10
InterPro	IPR011598
Pfam	PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR011598	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61286	F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:10545951^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:14576336^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:14576336^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:14576336^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15806-1	F		Seeded From UniProt	complete
enables	GO:0070644	vitamin D response element binding	PMID:17426122^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10545951^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15806-1	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15806-1	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:21828274^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99081	F	occurs_in:(CL:0002322)	Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:10545951^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
enables	GO:0035326	enhancer binding	PMID:21828274^[5]	ECO:0000305	curator inference used in manual assertion	GO:0000790	F	part_of:(CL:0002322) has_input:(ENSEMBL:ENSG00000243709)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21828274^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75593	F	occurs_in:(CL:0002322)\|occurs_in:(UBERON:0000925)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21828274^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)\|part_of:(UBERON:0000925)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21828274^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000925)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21828274^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
contributes_to	GO:0070888	E-box binding	PMID:10775504^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:7933101^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:12493738^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43680	F		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:14752053^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10775504^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:14752053^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:2105528^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19362560^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:2105528^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15806	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:10775504^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q7RTU7	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:14752053^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10958665^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	PMID:19801649^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02779	F		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:12435739^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:2493990^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:10775504^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:10775504^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10775504^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12493738^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:2493990^[15]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:14752053^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:2105528^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:2493990^[15]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10958665^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:2105528^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002326	B cell lineage commitment	PMID:12435739^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15923 UniProtKB:Q70IK3 WB:WBGene00001949	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:3829 RGD:69271 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000927455 RGD:620914 RGD:69271 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15923 WB:WBGene00001949	F		Seeded From UniProt	complete
involved_in	GO:0033152	immunoglobulin V(D)J recombination	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98510 PANTHER:PTN000209822 UniProtKB:P15923	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:620914 UniProtKB:P15923 UniProtKB:Q70IK3	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:3829 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:19323994^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16428437^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033152	immunoglobulin V(D)J recombination	PMID:16428437^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:11802795^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16043483^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15509787^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	PMID:11802795^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:10749989^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15672	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10749989^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15509787^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11802795^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	PMID:15044608^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15044608^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6QHK4	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:2503252^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10085	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:15044608^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:2503252^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	PMID:2503252^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:11802795^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16043483^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	PMID:11802795^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11802795^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000045	regulation of G1/S transition of mitotic cell cycle	PMID:11509675^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11509675^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12435739^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:11509675^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:12435739^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8759016^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:11509675^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12435739^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12435739^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11509675^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12435739^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8759016^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002326	B cell lineage commitment	PMID:15030778^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051149	positive regulation of muscle cell differentiation	Reactome:R-HSA-375170	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8956586 Reactome:R-HSA-8956568 Reactome:R-HSA-448963	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Malecki, MT et al. (1999) Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat. Genet. 23 323-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Smith, SB et al. (2004) Neurogenin3 activates the islet differentiation program while repressing its own expression. Mol. Endocrinol. 18 142-9 PubMed GONUTS page
↑ Turunen, MM et al. (2007) Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res. 35 2734-47 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Carlberg, AL et al. (2000) Regulation of scleraxis function by interaction with the bHLH protein E47. Mol. Cell Biol. Res. Commun. 3 82-6 PubMed GONUTS page
↑ Ou, SH et al. (1994) Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J. Virol. 68 7188-99 PubMed GONUTS page
↑ ^8.0 ^8.1 Funato, N et al. (2003) Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription. J. Biol. Chem. 278 7486-93 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Kim, JY et al. (2004) Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Mol. Endocrinol. 18 776-90 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Henthorn, P et al. (1990) Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science 247 467-70 PubMed GONUTS page
↑ Espira, L et al. (2009) The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. J. Mol. Cell. Cardiol. 47 188-95 PubMed GONUTS page
↑ ^12.0 ^12.1 Barndt, RJ et al. (2000) Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol. Cell. Biol. 20 6677-85 PubMed GONUTS page
↑ Pedraza, N et al. (2009) Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. J. Biol. Chem. 284 32980-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Bradney, C et al. (2003) Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278 2370-6 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Murre, C et al. (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56 777-83 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Joshi, K et al. (2009) LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron 61 839-51 PubMed GONUTS page
↑ ^18.0 ^18.1 Lazorchak, AS et al. (2006) E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol. Cell. Biol. 26 810-21 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Knöfler, M et al. (2002) Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. Biochem. J. 361 641-51 PubMed GONUTS page
↑ ^20.0 ^20.1 Morin, S et al. (2005) MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J. Biol. Chem. 280 32272-8 PubMed GONUTS page
↑ ^21.0 ^21.1 Hill, AA & Riley, PR (2004) Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2. Mol. Cell. Biol. 24 9835-47 PubMed GONUTS page
↑ ^22.0 ^22.1 El Ghouzzi, V et al. (2000) Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location. Hum. Mol. Genet. 9 813-9 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Bayne, RA et al. (2004) Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. Mol. Hum. Reprod. 10 373-81 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Murre, C et al. (1989) Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58 537-44 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 Zhao, F et al. (2001) Promotion of cell cycle progression by basic helix-loop-helix E2A. Mol. Cell. Biol. 21 6346-57 PubMed GONUTS page
↑ ^26.0 ^26.1 Loveys, DA et al. (1996) E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res. 24 2813-20 PubMed GONUTS page
↑ Ikawa, T et al. (2004) Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 20 349-60 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:10545951-2] 2.0 ^2.1 ^2.2 Malecki, MT et al. (1999) Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat. Genet. 23 323-8 PubMed GONUTS page

[PMID:14576336-3] 3.0 ^3.1 ^3.2 Smith, SB et al. (2004) Neurogenin3 activates the islet differentiation program while repressing its own expression. Mol. Endocrinol. 18 142-9 PubMed GONUTS page

[PMID:17426122-4] Turunen, MM et al. (2007) Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res. 35 2734-47 PubMed GONUTS page

[PMID:21828274-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page

[PMID:10775504-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Carlberg, AL et al. (2000) Regulation of scleraxis function by interaction with the bHLH protein E47. Mol. Cell Biol. Res. Commun. 3 82-6 PubMed GONUTS page

[PMID:7933101-7] Ou, SH et al. (1994) Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J. Virol. 68 7188-99 PubMed GONUTS page

[PMID:12493738-8] 8.0 ^8.1 Funato, N et al. (2003) Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription. J. Biol. Chem. 278 7486-93 PubMed GONUTS page

[PMID:14752053-9] 9.0 ^9.1 ^9.2 ^9.3 Kim, JY et al. (2004) Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Mol. Endocrinol. 18 776-90 PubMed GONUTS page

[PMID:2105528-10] 10.0 ^10.1 ^10.2 ^10.3 Henthorn, P et al. (1990) Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science 247 467-70 PubMed GONUTS page

[PMID:19362560-11] Espira, L et al. (2009) The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis. J. Mol. Cell. Cardiol. 47 188-95 PubMed GONUTS page

[PMID:10958665-12] 12.0 ^12.1 Barndt, RJ et al. (2000) Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol. Cell. Biol. 20 6677-85 PubMed GONUTS page

[PMID:19801649-13] Pedraza, N et al. (2009) Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. J. Biol. Chem. 284 32980-8 PubMed GONUTS page

[PMID:12435739-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Bradney, C et al. (2003) Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278 2370-6 PubMed GONUTS page

[PMID:2493990-15] 15.0 ^15.1 ^15.2 Murre, C et al. (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56 777-83 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19323994-17] Joshi, K et al. (2009) LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron 61 839-51 PubMed GONUTS page

[PMID:16428437-18] 18.0 ^18.1 Lazorchak, AS et al. (2006) E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol. Cell. Biol. 26 810-21 PubMed GONUTS page

[PMID:11802795-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Knöfler, M et al. (2002) Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. Biochem. J. 361 641-51 PubMed GONUTS page

[PMID:16043483-20] 20.0 ^20.1 Morin, S et al. (2005) MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J. Biol. Chem. 280 32272-8 PubMed GONUTS page

[PMID:15509787-21] 21.0 ^21.1 Hill, AA & Riley, PR (2004) Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2. Mol. Cell. Biol. 24 9835-47 PubMed GONUTS page

[PMID:10749989-22] 22.0 ^22.1 El Ghouzzi, V et al. (2000) Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location. Hum. Mol. Genet. 9 813-9 PubMed GONUTS page

[PMID:15044608-23] 23.0 ^23.1 ^23.2 Bayne, RA et al. (2004) Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. Mol. Hum. Reprod. 10 373-81 PubMed GONUTS page

[PMID:2503252-24] 24.0 ^24.1 ^24.2 Murre, C et al. (1989) Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58 537-44 PubMed GONUTS page

[PMID:11509675-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 Zhao, F et al. (2001) Promotion of cell cycle progression by basic helix-loop-helix E2A. Mol. Cell. Biol. 21 6346-57 PubMed GONUTS page

[PMID:8759016-26] 26.0 ^26.1 Loveys, DA et al. (1996) E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res. 24 2813-20 PubMed GONUTS page

[PMID:15030778-27] Ikawa, T et al. (2004) Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 20 349-60 PubMed GONUTS page

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