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PMID:2105528

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Citation

Henthorn, P, Kiledjian, M and Kadesch, T (1990) Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science 247:467-70

Abstract

Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.

Links

PubMed

Keywords

Animals; B-Lymphocytes/metabolism; Base Sequence; Binding Sites; Cell Line; Cloning, Molecular; DNA/genetics; DNA/metabolism; Enhancer Elements, Genetic; Genes, Immunoglobulin; Humans; Immunoglobulin kappa-Chains/genetics; Immunoglobulin mu-Chains/genetics; Macromolecular Substances; Mice; Molecular Sequence Data; Plasmids; Protein Conformation; Saccharomyces cerevisiae/genetics; Transcription Factors/metabolism; Transcription, Genetic; Transfection; Transformation, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ITF2

enables

GO:0046982: protein heterodimerization activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

HUMAN:ITF2

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ITF2

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TFE2

enables

GO:0046982: protein heterodimerization activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TFE2

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TFE2

enables

GO:0003677: DNA binding

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TFE2

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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