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HUMAN:PEBB

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CBFB
Protein Name(s) Core-binding factor subunit beta

CBF-beta Polyomavirus enhancer-binding protein 2 beta subunit PEA2-beta PEBP2-beta SL3-3 enhancer factor 1 subunit beta SL3/AKV core-binding factor beta subunit

External Links
UniProt Q13951
EMBL AF294326
BT006862
AK290462
CH471092
CH471092
BC018509
L20298
CCDS CCDS10827.1
CCDS45508.1
PIR A56840
I59579
RefSeq NP_001746.1
NP_074036.1
UniGene Hs.460988
PDB 1CL3
1E50
1H9D
4N9F
PDBsum 1CL3
1E50
1H9D
4N9F
ProteinModelPortal Q13951
SMR Q13951
BioGrid 107313
DIP DIP-36772N
IntAct Q13951
MINT MINT-1414765
STRING 9606.ENSP00000415151
ChEMBL CHEMBL2093862
PhosphoSite Q13951
DMDM 2498753
MaxQB Q13951
PaxDb Q13951
PeptideAtlas Q13951
PRIDE Q13951
DNASU 865
Ensembl ENST00000290858
ENST00000412916
GeneID 865
KEGG hsa:865
UCSC uc002era.3
uc002erb.3
CTD 865
GeneCards GC16P067063
HGNC HGNC:1539
HPA HPA038852
MIM 121360
neXtProt NX_Q13951
Orphanet 98829
PharmGKB PA26114
eggNOG NOG245525
GeneTree ENSGT00390000018132
HOGENOM HOG000008040
HOVERGEN HBG000541
InParanoid Q13951
OMA KECDFDK
PhylomeDB Q13951
TreeFam TF314675
ChiTaRS CBFB
EvolutionaryTrace Q13951
GeneWiki CBFB
GenomeRNAi 865
NextBio 3608
PRO PR:Q13951
Proteomes UP000005640
Bgee Q13951
CleanEx HS_CBFB
ExpressionAtlas Q13951
Genevestigator Q13951
GO GO:0016020
GO:0005634
GO:0003677
GO:0003700
GO:0003713
GO:0048469
GO:0060216
GO:0030098
GO:0030099
GO:0001649
GO:0045944
GO:0006366
Gene3D 2.40.250.10
InterPro IPR003417
PANTHER PTHR10276
Pfam PF02312
SUPFAM SSF50723

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000209

protein polyubiquitination

PMID:22190036[1]

ECO:0000315

P

Figure 4 indicates CBF-β's role in APOBEC3G ubiquitination

complete
CACAO 5212

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR003417

F

Seeded From UniProt

complete

involved_in

GO:0043378

positive regulation of CD8-positive, alpha-beta T cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q08024

P

Seeded From UniProt

complete

involved_in

GO:0043371

negative regulation of CD4-positive, alpha-beta T cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q08024

P

Seeded From UniProt

complete

contributes_to

GO:0043565

sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q08024

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q08024

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:22190036[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0043565

sequence-specific DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99851
PANTHER:PTN000814636

F

Seeded From UniProt

complete

part_of

GO:0016513

core-binding factor complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000814636
ZFIN:ZDB-GENE-980526-440

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013753
FB:FBgn0013755
MGI:MGI:99851
PANTHER:PTN000814636
WB:WBGene00000272

C

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013753
FB:FBgn0013755
PANTHER:PTN000814636

F

Seeded From UniProt

complete

enables

GO:0003712

transcription coregulator activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000814636
ZFIN:ZDB-GENE-980526-440

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000814636
RGD:620493

F

Seeded From UniProt

complete

involved_in

GO:0060216

definitive hemopoiesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

involved_in

GO:0048469

cell maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

F

Seeded From UniProt

complete

involved_in

GO:0043378

positive regulation of CD8-positive, alpha-beta T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

involved_in

GO:0043371

negative regulation of CD4-positive, alpha-beta T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

involved_in

GO:0030099

myeloid cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

involved_in

GO:0030098

lymphocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

C

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08024
ensembl:ENSMUSP00000059382

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q66HA7
ensembl:ENSRNOP00000019656

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003417
InterPro:IPR036552

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003417
InterPro:IPR036552

C

Seeded From UniProt

complete

part_of

GO:0016513

core-binding factor complex

PMID:18258917[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:8351518[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9751756[7]
PMID:8351518[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:2000810

regulation of bicellular tight junction assembly

Reactome:R-HSA-8935964

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902036

regulation of hematopoietic stem cell differentiation

Reactome:R-HSA-8939236

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050855

regulation of B cell receptor signaling pathway

Reactome:R-HSA-8939245

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045652

regulation of megakaryocyte differentiation

Reactome:R-HSA-8936459

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045637

regulation of myeloid cell differentiation

Reactome:R-HSA-8939246

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045616

regulation of keratinocyte differentiation

Reactome:R-HSA-8939242

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045589

regulation of regulatory T cell differentiation

Reactome:R-HSA-8877330

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033146

regulation of intracellular estrogen receptor signaling pathway

Reactome:R-HSA-8931987

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030111

regulation of Wnt signaling pathway

Reactome:R-HSA-8939256

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006367

transcription initiation from RNA polymerase II promoter

Reactome:R-HSA-212436

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-NUL-8939977
Reactome:R-HSA-9009451
Reactome:R-HSA-9009282
Reactome:R-HSA-9008877
Reactome:R-HSA-9008832
Reactome:R-HSA-9008822
Reactome:R-HSA-9008412
Reactome:R-HSA-8956649
Reactome:R-HSA-8956639
Reactome:R-HSA-8956586
Reactome:R-HSA-8956568
Reactome:R-HSA-8952081
Reactome:R-HSA-8952069
Reactome:R-HSA-8952062
Reactome:R-HSA-8952058
Reactome:R-HSA-8951977
Reactome:R-HSA-8951966
Reactome:R-HSA-8951951
Reactome:R-HSA-8951910
Reactome:R-HSA-8949335
Reactome:R-HSA-8940001
Reactome:R-HSA-8939833
Reactome:R-HSA-8939670
Reactome:R-HSA-8939082
Reactome:R-HSA-8939054
Reactome:R-HSA-8938965
Reactome:R-HSA-8938951
Reactome:R-HSA-8938938
Reactome:R-HSA-8938930
Reactome:R-HSA-8938913
Reactome:R-HSA-8938853
Reactome:R-HSA-8938389
Reactome:R-HSA-8938371
Reactome:R-HSA-8938328
Reactome:R-HSA-8938231
Reactome:R-HSA-8938228
Reactome:R-HSA-8938217
Reactome:R-HSA-8938199
Reactome:R-HSA-8938176
Reactome:R-HSA-8938150
Reactome:R-HSA-8938053
Reactome:R-HSA-8938022
Reactome:R-HSA-8937989
Reactome:R-HSA-8937118
Reactome:R-HSA-8937113
Reactome:R-HSA-8937050
Reactome:R-HSA-8937037
Reactome:R-HSA-8937022
Reactome:R-HSA-8937016
Reactome:R-HSA-8936989
Reactome:R-HSA-8936979
Reactome:R-HSA-8936621
Reactome:R-HSA-8936616
Reactome:R-HSA-8936608
Reactome:R-HSA-8936599
Reactome:R-HSA-8936584
Reactome:R-HSA-8936481
Reactome:R-HSA-8936000
Reactome:R-HSA-8935980
Reactome:R-HSA-8935960
Reactome:R-HSA-8935740
Reactome:R-HSA-8935732
Reactome:R-HSA-8935730
Reactome:R-HSA-8934742
Reactome:R-HSA-8934735
Reactome:R-HSA-8934688
Reactome:R-HSA-8932084
Reactome:R-HSA-8932037
Reactome:R-HSA-8932021
Reactome:R-HSA-8931981
Reactome:R-HSA-8878056
Reactome:R-HSA-8878054
Reactome:R-HSA-8878050
Reactome:R-HSA-8878013
Reactome:R-HSA-8877941
Reactome:R-HSA-8877879
Reactome:R-HSA-8877490
Reactome:R-HSA-8877485
Reactome:R-HSA-8877414
Reactome:R-HSA-8877404
Reactome:R-HSA-8877391
Reactome:R-HSA-8877385
Reactome:R-HSA-8877369
Reactome:R-HSA-8877360
Reactome:R-HSA-8877348
Reactome:R-HSA-8877338
Reactome:R-HSA-8877192
Reactome:R-HSA-8865547
Reactome:R-HSA-8865482
Reactome:R-HSA-8865454
Reactome:R-HSA-8865320

ECO:0000304

author statement supported by traceable reference used in manual assertion



























































































C

Seeded From UniProt

complete

involved_in

GO:0001959

regulation of cytokine-mediated signaling pathway

Reactome:R-HSA-8939247

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Zhang, W et al. (2012) T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction. Nature 481 376-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  3. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Setoguchi, R et al. (2008) Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319 822-5 PubMed GONUTS page
  6. ↑ 6.0 6.1 Liu, P et al. (1993) Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261 1041-4 PubMed GONUTS page
  7. ↑ Kogan, SC et al. (1998) The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc. Natl. Acad. Sci. U.S.A. 95 11863-8 PubMed GONUTS page
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