MOUSE:ISL1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Isl1
Protein Name(s)	Insulin gene enhancer protein ISL-1 Islet-1
External Links
UniProt	P61372
EMBL	AJ132765 AB104633
CCDS	CCDS26790.1
RefSeq	NP_067434.3 XP_006517596.1
UniGene	Mm.42242
PDB	2RGT 4JCJ
PDBsum	2RGT 4JCJ
ProteinModelPortal	P61372
SMR	P61372
BioGrid	200812
IntAct	P61372
MINT	MINT-4594016
PhosphoSite	P61372
MaxQB	P61372
PRIDE	P61372
Ensembl	ENSMUST00000036060 ENSMUST00000176044
GeneID	16392
KEGG	mmu:16392
UCSC	uc007rye.2 uc007ryf.2
CTD	3670
MGI	MGI:101791
eggNOG	COG5576
GeneTree	ENSGT00760000118921
HOGENOM	HOG000236304
HOVERGEN	HBG004671
InParanoid	P61372
KO	K09370
OMA	TDMGDMG
OrthoDB	EOG7JQBPW
PhylomeDB	P61372
TreeFam	TF315442
Reactome	REACT_253751
EvolutionaryTrace	P61372
NextBio	289537
PRO	PR:P61372
Proteomes	UP000000589
Bgee	P61372
CleanEx	MM_ISL1
ExpressionAtlas	P61372
Genevestigator	P61372
GO	GO:0005622 GO:0005634 GO:0003682 GO:0003677 GO:0001158 GO:0001105 GO:0008270 GO:0060413 GO:0031103 GO:0060913 GO:0060379 GO:0003215 GO:0071385 GO:0003203 GO:0007507 GO:0003007 GO:0060384 GO:0048762 GO:0090090 GO:0050728 GO:0033147 GO:0043524 GO:0045665 GO:0090074 GO:0000122 GO:0045892 GO:0001755 GO:0030182 GO:0048663 GO:0048665 GO:0003151 GO:0003148 GO:0031016 GO:0048936 GO:0048935 GO:0060037 GO:0021983 GO:0045766 GO:0008284 GO:0043388 GO:0071657 GO:0032725 GO:0032024 GO:0032729 GO:0032730 GO:0032731 GO:0032735 GO:0032755 GO:1901258 GO:0045944 GO:0032760 GO:0042517 GO:0010575 GO:0010468 GO:0003266 GO:0031290 GO:0003139 GO:0048880 GO:0021520 GO:0021522 GO:0021559 GO:0055010 GO:0021524
Gene3D	1.10.10.60 2.10.110.10
InterPro	IPR017970 IPR001356 IPR009057 IPR001781
Pfam	PF00046 PF00412
SMART	SM00389 SM00132
SUPFAM	SSF46689
PROSITE	PS00027 PS50071 PS00478 PS50023

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035066	positive regulation of histone acetylation	PMID:24147056^[1]	ECO:0000315			P		Figure 5 shows the effect of Islet-1 on the acetylation levels of histone H3 compared to the acetylation levels of H3 in progenitor cells.	complete CACAO 9025
enables	GO:0043565	sequence-specific DNA binding	PMID:24643061^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:24643061^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24643061^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:24147056^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:25775587^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901258	positive regulation of macrophage colony-stimulating factor production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071657	positive regulation of granulocyte colony-stimulating factor production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060413	atrial septum morphogenesis	PMID:17519333^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0060384	innervation	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:17519333^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:17519333^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:22727192^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048936	peripheral nervous system neuron axonogenesis	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048880	sensory system development	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048665	neuron fate specification	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:22727192^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032730	positive regulation of interleukin-1 alpha production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021559	trigeminal nerve development	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:22727192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	PMID:17519333^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	PMID:17519333^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:17519333^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:17519333^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18849985^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50211	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14664703^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14664703^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048665	neuron fate specification	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101791 MGI:MGI:109156 PANTHER:PTN001197637 ZFIN:ZDB-GENE-980526-112 ZFIN:ZDB-GENE-980526-562	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003896 MGI:MGI:101791 PANTHER:PTN000653991 RGD:61957 UniProtKB:P61371	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003896 MGI:MGI:101791 MGI:MGI:109156 PANTHER:PTN001197637 ZFIN:ZDB-GENE-980526-112 ZFIN:ZDB-GENE-980526-562	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003896 MGI:MGI:101791 MGI:MGI:109156 PANTHER:PTN001197649 RGD:61957 UniProtKB:P50211 UniProtKB:P61371 WB:WBGene00002989 ZFIN:ZDB-GENE-980526-112	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003896 PANTHER:PTN001197649 RGD:61957 UniProtKB:P61371	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19620969^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P	regulates_o_occurs_in:(EMAPA:16039) regulates_o_occurs_in:(CL:0002664)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090074	negative regulation of protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060913	cardiac cell fate determination	PMID:19620969^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060913	cardiac cell fate determination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060379	cardiac muscle cell myoblast differentiation	PMID:19620969^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048935	peripheral nervous system neuron development	PMID:21734270^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102525	P	results_in_development_of:(CL:1001451)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048762	mesenchymal cell differentiation	PMID:9000074^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182246	P	occurs_in:(EMAPA:17066) results_in_acquisition_of_features_of:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:14766174^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109156	P	has_participant:(EMAPA:17577) results_in_commitment_to:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18434421^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102524	P	has_regulation_target:(MGI:MGI:102525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22343712^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746) regulates_o_occurs_in:(CL:0000746) regulates_o_has_input:(MGI:MGI:99458)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19620969^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:14766174^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109156	P	occurs_in:(EMAPA:17577) regulates_o_results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043388	positive regulation of DNA binding	PMID:15659653^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:15659653^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031290	retinal ganglion cell axon guidance	PMID:18434421^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3790243	P	occurs_in:(EMAPA:16896) occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031016	pancreas development	PMID:9000074^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182246	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:18434416^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102524	P	occurs_in:(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:8565076^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182246	P	occurs_in:(EMAPA:16478) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:18367596^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574771,MGI:MGI:3797783	P	occurs_in:(EMAPA:16895) results_in_acquisition_of_features_of:(CL:0000108)\|results_in_acquisition_of_features_of:(CL:0000108)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021983	pituitary gland development	PMID:9806931^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182246	P	results_in_development_of:(EMAPA:16725)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021524	visceral motor neuron differentiation	PMID:14766174^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109156	P	occurs_in:(EMAPA:17577) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021522	spinal cord motor neuron differentiation	PMID:8565076^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182246	P	occurs_in:(EMAPA:16525) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021520	spinal cord motor neuron cell fate specification	PMID:19666821^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102673	P	occurs_in:(EMAPA:16525)	Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:19666821^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182246 MGI:MGI:3817457	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15659653^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:14667410^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182246	P	results_in_development_of:(EMAPA:16350)\|results_in_development_of:(EMAPA:16346)\|results_in_development_of:(EMAPA:16342)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25433207^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24821700^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23610558^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19666821^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18434421^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17928203^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15659653^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14702043^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18816) part_of:(CL:0000169)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12900460^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000059)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10536059^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16525)\|part_of:(EMAPA:17577)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:15659653^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21734270^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19620969^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18434421^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17168) has_participant:(MGI:MGI:102524)\|occurs_in(EMAPA:17168) has_participant:(MGI:MGI:98297)\|occurs_in(EMAPA:17168) has_participant:(MGI:MGI:102525)\|occurs_in(EMAPA:17168) has_participant:(MGI:MGI:109156)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:19620969^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003266	regulation of secondary heart field cardioblast proliferation	PMID:19620969^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447758	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003139	secondary heart field specification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:16687132^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	PMID:16687132^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108075	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	F		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61371	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61957	F		Seeded From UniProt	complete
involved_in	GO:0090074	negative regulation of protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	F		Seeded From UniProt	complete
involved_in	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
involved_in	GO:0031103	axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	F		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	F		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61374 ensembl:ENSRNOP00000017305	F		Seeded From UniProt	complete
involved_in	GO:0060913	cardiac cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	C		Seeded From UniProt	complete
involved_in	GO:0003139	secondary heart field specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	P		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61371 ensembl:ENSP00000230658	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9010548	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yu, Z et al. (2013) Islet-1 may function as an assistant factor for histone acetylation and regulation of cardiac development-related transcription factor Mef2c expression. PLoS ONE 8 e77690 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Li, R et al. (2014) Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. PLoS ONE 9 e92105 PubMed GONUTS page
↑ Wu, F et al. (2015) Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc. Natl. Acad. Sci. U.S.A. 112 E1559-68 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Barzelay, A et al. (2012) Islet-1 gene delivery improves myocardial performance after experimental infarction. Atherosclerosis 223 284-90 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Lin, L et al. (2007) Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc. Natl. Acad. Sci. U.S.A. 104 9313-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Sun, Y et al. (2008) A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat. Neurosci. 11 1283-93 PubMed GONUTS page
↑ ^7.0 ^7.1 Ando, K et al. (2003) Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1. J. Mol. Endocrinol. 31 419-25 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Kwon, C et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat. Cell Biol. 11 951-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Dykes, IM et al. (2011) Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J. Neurosci. 31 9789-99 PubMed GONUTS page
↑ ^11.0 ^11.1 Ahlgren, U et al. (1997) Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385 257-60 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Thaler, JP et al. (2004) A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron 41 337-50 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Pan, L et al. (2008) ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development 135 1981-90 PubMed GONUTS page
↑ Huang, ZP et al. (2012) CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ. Res. 110 818-30 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Hao, A et al. (2005) The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol. Biol. Cell 16 1569-83 PubMed GONUTS page
↑ Mak, KK et al. (2008) Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development 135 1947-56 PubMed GONUTS page
↑ ^17.0 ^17.1 Pfaff, SL et al. (1996) Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84 309-20 PubMed GONUTS page
↑ Elshatory, Y & Gan, L (2008) The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J. Neurosci. 28 3291-7 PubMed GONUTS page
↑ Takuma, N et al. (1998) Formation of Rathke's pouch requires dual induction from the diencephalon. Development 125 4835-40 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Song, MR et al. (2009) Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development 136 2923-32 PubMed GONUTS page
↑ Cai, CL et al. (2003) Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 5 877-89 PubMed GONUTS page
↑ Serinagaoglu, Y et al. (2015) Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev. Biol. 398 97-109 PubMed GONUTS page
↑ Vincent, SD et al. (2014) Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum. Mol. Genet. 23 5087-101 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ Wang, S et al. () Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech. Dev. 124 898-910 PubMed GONUTS page
↑ Sumazaki, R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet. 36 83-7 PubMed GONUTS page
↑ Mitsiadis, TA et al. (2003) Role of Islet1 in the patterning of murine dentition. Development 130 4451-60 PubMed GONUTS page
↑ Hao, Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev. Dyn. 216 201-17 PubMed GONUTS page
↑ ^29.0 ^29.1 Lin, L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev. Biol. 295 756-63 PubMed GONUTS page

[PMID:24147056-1] 1.0 ^1.1 Yu, Z et al. (2013) Islet-1 may function as an assistant factor for histone acetylation and regulation of cardiac development-related transcription factor Mef2c expression. PLoS ONE 8 e77690 PubMed GONUTS page

[PMID:24643061-2] 2.0 ^2.1 ^2.2 Li, R et al. (2014) Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. PLoS ONE 9 e92105 PubMed GONUTS page

[PMID:25775587-3] Wu, F et al. (2015) Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc. Natl. Acad. Sci. U.S.A. 112 E1559-68 PubMed GONUTS page

[PMID:22727192-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Barzelay, A et al. (2012) Islet-1 gene delivery improves myocardial performance after experimental infarction. Atherosclerosis 223 284-90 PubMed GONUTS page

[PMID:17519333-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Lin, L et al. (2007) Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc. Natl. Acad. Sci. U.S.A. 104 9313-8 PubMed GONUTS page

[PMID:18849985-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Sun, Y et al. (2008) A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat. Neurosci. 11 1283-93 PubMed GONUTS page

[PMID:14664703-7] 7.0 ^7.1 Ando, K et al. (2003) Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1. J. Mol. Endocrinol. 31 419-25 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19620969-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Kwon, C et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat. Cell Biol. 11 951-7 PubMed GONUTS page

[PMID:21734270-10] 10.0 ^10.1 Dykes, IM et al. (2011) Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J. Neurosci. 31 9789-99 PubMed GONUTS page

[PMID:9000074-11] 11.0 ^11.1 Ahlgren, U et al. (1997) Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385 257-60 PubMed GONUTS page

[PMID:14766174-12] 12.0 ^12.1 ^12.2 Thaler, JP et al. (2004) A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron 41 337-50 PubMed GONUTS page

[PMID:18434421-13] 13.0 ^13.1 ^13.2 ^13.3 Pan, L et al. (2008) ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development 135 1981-90 PubMed GONUTS page

[PMID:22343712-14] Huang, ZP et al. (2012) CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ. Res. 110 818-30 PubMed GONUTS page

[PMID:15659653-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Hao, A et al. (2005) The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol. Biol. Cell 16 1569-83 PubMed GONUTS page

[PMID:18434416-16] Mak, KK et al. (2008) Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development 135 1947-56 PubMed GONUTS page

[PMID:8565076-17] 17.0 ^17.1 Pfaff, SL et al. (1996) Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84 309-20 PubMed GONUTS page

[PMID:18367596-18] Elshatory, Y & Gan, L (2008) The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J. Neurosci. 28 3291-7 PubMed GONUTS page

[PMID:9806931-19] Takuma, N et al. (1998) Formation of Rathke's pouch requires dual induction from the diencephalon. Development 125 4835-40 PubMed GONUTS page

[PMID:19666821-20] 20.0 ^20.1 ^20.2 Song, MR et al. (2009) Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development 136 2923-32 PubMed GONUTS page

[PMID:14667410-21] Cai, CL et al. (2003) Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 5 877-89 PubMed GONUTS page

[PMID:25433207-22] Serinagaoglu, Y et al. (2015) Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev. Biol. 398 97-109 PubMed GONUTS page

[PMID:24821700-23] Vincent, SD et al. (2014) Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum. Mol. Genet. 23 5087-101 PubMed GONUTS page

[PMID:23610558-24] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:17928203-25] Wang, S et al. () Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech. Dev. 124 898-910 PubMed GONUTS page

[PMID:14702043-26] Sumazaki, R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet. 36 83-7 PubMed GONUTS page

[PMID:12900460-27] Mitsiadis, TA et al. (2003) Role of Islet1 in the patterning of murine dentition. Development 130 4451-60 PubMed GONUTS page

[PMID:10536059-28] Hao, Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev. Dyn. 216 201-17 PubMed GONUTS page

[PMID:16687132-29] 29.0 ^29.1 Lin, L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev. Biol. 295 756-63 PubMed GONUTS page

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MOUSE:ISL1

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