MOUSE:EP300

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ep300 (synonyms: P300)
Protein Name(s)	Histone acetyltransferase p300 p300 HAT E1A-associated protein p300
External Links
UniProt	B2RWS6
EMBL	AC102262 AC160528 BC144976 BC150681
CCDS	CCDS37149.1
RefSeq	NP_808489.4
UniGene	Mm.258397
ProteinModelPortal	B2RWS6
SMR	B2RWS6
DIP	DIP-60610N
IntAct	B2RWS6
STRING	10090.ENSMUSP00000066789
PaxDb	B2RWS6
PRIDE	B2RWS6
Ensembl	ENSMUST00000068387
GeneID	328572
KEGG	mmu:328572
CTD	2033
MGI	MGI:1276116
eggNOG	COG5076
GeneTree	ENSGT00760000119206
HOGENOM	HOG000111353
HOVERGEN	HBG000185
InParanoid	B2RWS6
KO	K04498
OMA	PTMIRGS
PhylomeDB	B2RWS6
Reactome	REACT_118837 REACT_196464 REACT_196589 REACT_196591 REACT_196593 REACT_198351 REACT_198352 REACT_198521 REACT_198602 REACT_198649 REACT_199107 REACT_216539 REACT_223626 REACT_223784 REACT_231481 REACT_241925 REACT_24972 REACT_252217 REACT_268602 REACT_27166
ChiTaRS	Ep300
NextBio	398354
PRO	PR:B2RWS6
Proteomes	UP000000589
Genevestigator	B2RWS6
GO	GO:0000785 GO:0005737 GO:0000123 GO:0005654 GO:0005634 GO:0032993 GO:0005667 GO:0016407 GO:0003823 GO:0031490 GO:0003677 GO:0004402 GO:0004468 GO:0002039 GO:0097157 GO:0001102 GO:0000978 GO:0000979 GO:0001085 GO:0001228 GO:0003713 GO:0008134 GO:0008270 GO:0006915 GO:0051216 GO:0007049 GO:0071320 GO:0071549 GO:0035690 GO:0071333 GO:0070301 GO:0071389 GO:1990090 GO:0071300 GO:0035984 GO:0007623 GO:0048565 GO:0007507 GO:0043969 GO:0043966 GO:0043967 GO:0006475 GO:0042771 GO:0001889 GO:0030324 GO:0018076 GO:0043154 GO:2000629 GO:0000122 GO:0009887 GO:0043923 GO:0045773 GO:0010942 GO:0045793 GO:0032967 GO:0043388 GO:0010560 GO:0014737 GO:1901985 GO:0032092 GO:0033160 GO:0001934 GO:0050714 GO:0045862 GO:0060298 GO:0051091 GO:0045944 GO:0045893 GO:0045727 GO:0043491 GO:0065004 GO:0060765 GO:0060177 GO:0006355 GO:0090043 GO:0051592 GO:0032025 GO:0043627 GO:0045471 GO:0070542 GO:0001666 GO:0034612 GO:0007519 GO:0001756
Gene3D	1.10.1630.10 1.10.246.20 1.20.1020.10 1.20.920.10
InterPro	IPR001487 IPR018359 IPR010303 IPR013178 IPR003101 IPR009110 IPR014744 IPR000197 IPR000433
Pfam	PF00439 PF09030 PF06001 PF08214 PF02172 PF02135 PF00569
PRINTS	PR00503
SMART	SM00297 SM00551 SM00291
SUPFAM	SSF47040 SSF47370 SSF57933 SSF69125
PROSITE	PS00633 PS50014 PS51727 PS50952 PS50134 PS01357 PS50135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060235	lens induction in camera-type eye	PMID:24038357^[1]	ECO:0000316		UniProtKB:P45481	P		Figure 3 details lens induction and the morphogenic differences observed in mutant mice.	complete CACAO 8913
involved_in	GO:0035264	multicellular organism growth	PMID:19822209^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(UBERON:0000092)	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	PMID:19822209^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036268	swimming	PMID:19822209^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:19822209^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001966	thigmotaxis	PMID:19822209^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002209	behavioral defense response	PMID:19822209^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
involved_in	GO:0010742	macrophage derived foam cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16245309^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	PMID:27105113^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:27105113^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0140069	histone butyryltransferase activity	PMID:27105113^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0140067	peptidyl-lysine butyrylation	PMID:27105113^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0140068	histone crotonyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0061920	protein propionyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
involved_in	GO:0140066	peptidyl-lysine crotonylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0061921	peptidyl-lysine propionylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0045815	positive regulation of gene expression, epigenetic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:24216764^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18486321^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28033	F		Seeded From UniProt	complete
involved_in	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	PMID:20955178^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016407	acetyltransferase activity	PMID:20955178^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006473	protein acetylation	PMID:20955178^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:20955178^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090043	regulation of tubulin deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:19828133^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:10518217^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9512516^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19828133^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043969	histone H2B acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0043967	histone H4 acetylation	PMID:16325578^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0018076	N-terminal peptidyl-lysine acetylation	PMID:12435739^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0016407	acetyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0016407	acetyltransferase activity	PMID:12435739^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17641689^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q71SY5	F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:14645221^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:9194565^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0006475	internal protein amino acid acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15261140^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:19828133^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9194565^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	C		Seeded From UniProt	complete
enables	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:12040021^[17]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17641689^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(UniProtKB:Q71SY5)\|has_regulation_target:(UniProtKB:P10276)	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12586840^[18]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12435739^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9194565^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:15261140^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000629	negative regulation of miRNA metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:1990405	protein antigen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901985	positive regulation of protein acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0140068	histone crotonyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0140067	peptidyl-lysine butyrylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0140066	peptidyl-lysine crotonylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0140065	peptide butyryltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0097677	STAT family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0097157	pre-mRNA intronic binding	PMID:23752591^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090043	regulation of tubulin deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071548	response to dexamethasone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065004	protein-DNA complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061921	peptidyl-lysine propionylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0061920	protein propionyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060298	positive regulation of sarcomere organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060177	regulation of angiotensin metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051592	response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:24565863^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:102541)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050714	positive regulation of protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24759103^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:3577024	P	has_regulation_target:(MGI:MGI:1316649) occurs_in:(CL:0000115) regulates_o_occurs_in:(CL:0000115)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16801560^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103302 MGI:MGI:1919200	P	regulates_o_occurs_in:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15616592^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1913208	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15199055^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104661 MGI:MGI:1342774	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15100295^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045862	positive regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045815	positive regulation of gene expression, epigenetic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045793	positive regulation of cell size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045773	positive regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045727	positive regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043969	histone H2B acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043967	histone H4 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043966	histone H3 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043923	positive regulation by host of viral transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043491	protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043388	positive regulation of DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035855	megakaryocyte development	PMID:18684867^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3813243	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035066	positive regulation of histone acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034644	cellular response to UV	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15616592^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032460	negative regulation of protein oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	PMID:16619037^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_input:(MGI:MGI:1306784) has_regulation_target:(MGI:MGI:120674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:18458156^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031325	positive regulation of cellular metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031324	negative regulation of cellular metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:14517255^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679374	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030307	positive regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030220	platelet formation	PMID:18684867^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97076	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030220	platelet formation	PMID:18684867^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3813243	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030183	B cell differentiation	PMID:18684867^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3813243	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018394	peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018394	peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018393	internal peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018393	internal peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018076	N-terminal peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016573	histone acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016573	histone acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
enables	GO:0016407	acetyltransferase activity	PMID:24565863^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:102541) has_direct_input:(MGI:MGI:102541)	Seeded From UniProt	complete
enables	GO:0016407	acetyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014737	positive regulation of muscle atrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010742	macrophage derived foam cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:22523253^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1098280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010560	positive regulation of glycoprotein biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:14517255^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679374	P	has_participant:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009749	response to glucose	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:17150957^[31]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007519	skeletal muscle tissue development	PMID:14517256^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679374	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:14517255^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679374	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006475	internal protein amino acid acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006473	protein acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12464179^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:11567019^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12464179^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	C		Seeded From UniProt	complete
enables	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0003823	antigen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15681609^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15601870^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:17591690^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:15937931^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1343101	P	has_participant:(EMAPA:16172)\|has_participant:(EMAPA:16184)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22780989^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:18605988^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07243	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18605988^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07243	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23752591^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620036	C		Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	PMID:9742083^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q09472	P		Seeded From UniProt	complete
involved_in	GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0140068	histone crotonyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0140067	peptidyl-lysine butyrylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0140066	peptidyl-lysine crotonylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0140065	peptide butyryltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0097677	STAT family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0090043	regulation of tubulin deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0061921	peptidyl-lysine propionylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0061920	protein propionyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0045815	positive regulation of gene expression, epigenetic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0043969	histone H2B acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0043967	histone H4 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0043923	positive regulation by host of viral transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0032460	negative regulation of protein oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0018394	peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0018393	internal peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0018076	N-terminal peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0016407	acetyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0010742	macrophage derived foam cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0006475	internal protein amino acid acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0006473	protein acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	C		Seeded From UniProt	complete
enables	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q09472 ensembl:ENSP00000263253	P		Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014744	C		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000197 InterPro:IPR003101 InterPro:IPR036529	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014744	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000197 InterPro:IPR013178 InterPro:IPR014744	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000197 InterPro:IPR014744	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000197 InterPro:IPR003101 InterPro:IPR013178 InterPro:IPR014744 InterPro:IPR036529	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000197 InterPro:IPR000433	F		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013178 InterPro:IPR014744	P		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.48	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9017420 Reactome:R-MMU-9016915 Reactome:R-MMU-5693628 Reactome:R-MMU-5663294 Reactome:R-MMU-5663291 Reactome:R-MMU-5663266 Reactome:R-MMU-5663256 Reactome:R-MMU-5619441 Reactome:R-MMU-5619434 Reactome:R-MMU-5619411 Reactome:R-MMU-5617990 Reactome:R-MMU-5617960 Reactome:R-MMU-556760 Reactome:R-MMU-4396387 Reactome:R-MMU-2976706 Reactome:R-MMU-1368101	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wolf, L et al. (2013) Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res. 41 10199-214 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Viosca, J et al. (2010) Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology. Neurobiol. Dis. 37 186-94 PubMed GONUTS page
↑ Giacinti, C et al. (2006) MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions. J. Cell. Physiol. 206 807-13 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Goudarzi, A et al. (2016) Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol. Cell 62 169-180 PubMed GONUTS page
↑ Zhao, Y et al. (2014) p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation. Mol. Cell. Biol. 34 315-24 PubMed GONUTS page
↑ Ceseña, TI et al. (2008) Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription. Mol. Cell. Endocrinol. 289 94-101 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Wang, FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433 245-52 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Furumatsu, T et al. (2010) Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription. Int. J. Biochem. Cell Biol. 42 148-56 PubMed GONUTS page
↑ Shikama, N et al. (1999) A novel cofactor for p300 that regulates the p53 response. Mol. Cell 4 365-76 PubMed GONUTS page
↑ Mutoh, H et al. (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12 820-30 PubMed GONUTS page
↑ Kang, J et al. (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 833-47 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Bradney, C et al. (2003) Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278 2370-6 PubMed GONUTS page
↑ ^13.0 ^13.1 Lee, HK et al. (2007) MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J. 26 3545-57 PubMed GONUTS page
↑ Curtis, AM et al. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J. Biol. Chem. 279 7091-7 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Lill, NL et al. (1997) Binding and modulation of p53 by p300/CBP coactivators. Nature 387 823-7 PubMed GONUTS page
↑ ^16.0 ^16.1 Kung, AL et al. (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33-43 PubMed GONUTS page
↑ Brendel, C et al. (2002) Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. Mol. Endocrinol. 16 1367-77 PubMed GONUTS page
↑ Bragança, J et al. (2003) Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J. Biol. Chem. 278 16021-9 PubMed GONUTS page
↑ ^19.0 ^19.1 Proserpio, V et al. (2013) The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 27 1299-312 PubMed GONUTS page
↑ ^20.0 ^20.1 Lewandowski, SL et al. (2014) Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Hum. Mol. Genet. 23 3801-9 PubMed GONUTS page
↑ de Assuncao, TM et al. (2014) New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J. Biol. Chem. 289 15798-809 PubMed GONUTS page
↑ Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page
↑ ^23.0 ^23.1 Covic, M et al. (2005) Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 24 85-96 PubMed GONUTS page
↑ Lau, P et al. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J. Biol. Chem. 279 36828-40 PubMed GONUTS page
↑ Yee, CS et al. (2004) Cathepsin E: a novel target for regulation by class II transactivator. J. Immunol. 172 5528-34 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Kauppi, M et al. (2008) Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood 112 3148-53 PubMed GONUTS page
↑ Chou, YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene 25 5547-60 PubMed GONUTS page
↑ Shang, Y et al. (2008) Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation. J. Cell Biol. 181 461-73 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Shikama, N et al. (2003) Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J. 22 5175-85 PubMed GONUTS page
↑ Pentz, ES et al. (2012) Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype. Am. J. Physiol. Heart Circ. Physiol. 302 H2545-52 PubMed GONUTS page
↑ Shen, Y et al. (2007) Functional architecture of atrophins. J. Biol. Chem. 282 5037-44 PubMed GONUTS page
↑ Roth, JF et al. (2003) Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 22 5186-96 PubMed GONUTS page
↑ ^33.0 ^33.1 Kioussi, C et al. (2002) Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111 673-85 PubMed GONUTS page
↑ Kim, RH et al. (2001) SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J. Biol. Chem. 276 46297-304 PubMed GONUTS page
↑ Guan, HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 19 453-61 PubMed GONUTS page
↑ Kabe, Y et al. (2005) NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol. Cell. Biol. 25 512-22 PubMed GONUTS page
↑ Lee, JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell. Sci. 120 2259-71 PubMed GONUTS page
↑ Phan, HM et al. (2005) GCN5 and p300 share essential functions during early embryogenesis. Dev. Dyn. 233 1337-47 PubMed GONUTS page
↑ Faure, AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22 2163-75 PubMed GONUTS page
↑ ^40.0 ^40.1 Kimura, T et al. (2008) Chromium(VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Biochem. J. 415 477-82 PubMed GONUTS page
↑ Xu, W et al. (1998) Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol. Cell. Biol. 18 5659-69 PubMed GONUTS page

[PMID:24038357-1] Wolf, L et al. (2013) Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res. 41 10199-214 PubMed GONUTS page

[PMID:19822209-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Viosca, J et al. (2010) Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology. Neurobiol. Dis. 37 186-94 PubMed GONUTS page

[PMID:16245309-3] Giacinti, C et al. (2006) MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions. J. Cell. Physiol. 206 807-13 PubMed GONUTS page

[PMID:27105113-4] 4.0 ^4.1 ^4.2 ^4.3 Goudarzi, A et al. (2016) Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol. Cell 62 169-180 PubMed GONUTS page

[PMID:24216764-5] Zhao, Y et al. (2014) p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation. Mol. Cell. Biol. 34 315-24 PubMed GONUTS page

[PMID:18486321-6] Ceseña, TI et al. (2008) Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription. Mol. Cell. Endocrinol. 289 94-101 PubMed GONUTS page

[PMID:20955178-7] 7.0 ^7.1 ^7.2 ^7.3 Wang, FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem. J. 433 245-52 PubMed GONUTS page

[PMID:19828133-8] 8.0 ^8.1 ^8.2 Furumatsu, T et al. (2010) Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription. Int. J. Biochem. Cell Biol. 42 148-56 PubMed GONUTS page

[PMID:10518217-9] Shikama, N et al. (1999) A novel cofactor for p300 that regulates the p53 response. Mol. Cell 4 365-76 PubMed GONUTS page

[PMID:9512516-10] Mutoh, H et al. (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12 820-30 PubMed GONUTS page

[PMID:16325578-11] Kang, J et al. (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 833-47 PubMed GONUTS page

[PMID:12435739-12] 12.0 ^12.1 ^12.2 Bradney, C et al. (2003) Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278 2370-6 PubMed GONUTS page

[PMID:17641689-13] 13.0 ^13.1 Lee, HK et al. (2007) MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J. 26 3545-57 PubMed GONUTS page

[PMID:14645221-14] Curtis, AM et al. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J. Biol. Chem. 279 7091-7 PubMed GONUTS page

[PMID:9194565-15] 15.0 ^15.1 ^15.2 Lill, NL et al. (1997) Binding and modulation of p53 by p300/CBP coactivators. Nature 387 823-7 PubMed GONUTS page

[PMID:15261140-16] 16.0 ^16.1 Kung, AL et al. (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33-43 PubMed GONUTS page

[PMID:12040021-17] Brendel, C et al. (2002) Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. Mol. Endocrinol. 16 1367-77 PubMed GONUTS page

[PMID:12586840-18] Bragança, J et al. (2003) Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J. Biol. Chem. 278 16021-9 PubMed GONUTS page

[PMID:23752591-19] 19.0 ^19.1 Proserpio, V et al. (2013) The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 27 1299-312 PubMed GONUTS page

[PMID:24565863-20] 20.0 ^20.1 Lewandowski, SL et al. (2014) Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Hum. Mol. Genet. 23 3801-9 PubMed GONUTS page

[PMID:24759103-21] Assuncao, TM et al. (2014) New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J. Biol. Chem. 289 15798-809 PubMed GONUTS page

[PMID:16801560-22] Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page

[PMID:15616592-23] 23.0 ^23.1 Covic, M et al. (2005) Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 24 85-96 PubMed GONUTS page

[PMID:15199055-24] Lau, P et al. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J. Biol. Chem. 279 36828-40 PubMed GONUTS page

[PMID:15100295-25] Yee, CS et al. (2004) Cathepsin E: a novel target for regulation by class II transactivator. J. Immunol. 172 5528-34 PubMed GONUTS page

[PMID:18684867-26] 26.0 ^26.1 ^26.2 ^26.3 Kauppi, M et al. (2008) Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood 112 3148-53 PubMed GONUTS page

[PMID:16619037-27] Chou, YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene 25 5547-60 PubMed GONUTS page

[PMID:18458156-28] Shang, Y et al. (2008) Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation. J. Cell Biol. 181 461-73 PubMed GONUTS page

[PMID:14517255-29] 29.0 ^29.1 ^29.2 Shikama, N et al. (2003) Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J. 22 5175-85 PubMed GONUTS page

[PMID:22523253-30] Pentz, ES et al. (2012) Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype. Am. J. Physiol. Heart Circ. Physiol. 302 H2545-52 PubMed GONUTS page

[PMID:17150957-31] Shen, Y et al. (2007) Functional architecture of atrophins. J. Biol. Chem. 282 5037-44 PubMed GONUTS page

[PMID:14517256-32] Roth, JF et al. (2003) Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 22 5186-96 PubMed GONUTS page

[PMID:12464179-33] 33.0 ^33.1 Kioussi, C et al. (2002) Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111 673-85 PubMed GONUTS page

[PMID:11567019-34] Kim, RH et al. (2001) SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J. Biol. Chem. 276 46297-304 PubMed GONUTS page

[PMID:15681609-35] Guan, HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 19 453-61 PubMed GONUTS page

[PMID:15601870-36] Kabe, Y et al. (2005) NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol. Cell. Biol. 25 512-22 PubMed GONUTS page

[PMID:17591690-37] Lee, JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell. Sci. 120 2259-71 PubMed GONUTS page

[PMID:15937931-38] Phan, HM et al. (2005) GCN5 and p300 share essential functions during early embryogenesis. Dev. Dyn. 233 1337-47 PubMed GONUTS page

[PMID:22780989-39] Faure, AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22 2163-75 PubMed GONUTS page

[PMID:18605988-40] 40.0 ^40.1 Kimura, T et al. (2008) Chromium(VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Biochem. J. 415 477-82 PubMed GONUTS page

[PMID:9742083-41] Xu, W et al. (1998) Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol. Cell. Biol. 18 5659-69 PubMed GONUTS page

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