MOUSE:NCOA6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ncoa6 (synonyms: Aib3, Prip, Rap250, Trbp)
Protein Name(s)	Nuclear receptor coactivator 6 Activating signal cointegrator 2 ASC-2 Amplified in breast cancer protein 3 Cancer-amplified transcriptional coactivator ASC-2 Nuclear receptor coactivator RAP250 NRC Nuclear receptor-activating protein, 250 kDa Peroxisome proliferator-activated receptor-interacting protein PPAR-interacting protein Thyroid hormone receptor-binding protein
External Links
UniProt	Q9JL19
EMBL	AF216186 BC031113 AF135169
UniGene	Mm.27592
ProteinModelPortal	Q9JL19
IntAct	Q9JL19
MINT	MINT-5200950
PhosphoSite	Q9JL19
MaxQB	Q9JL19
PaxDb	Q9JL19
PRIDE	Q9JL19
MGI	MGI:1929915
eggNOG	NOG12793
HOVERGEN	HBG052586
InParanoid	Q9JL19
ChiTaRS	Ncoa6
PRO	PR:Q9JL19
Proteomes	UP000000589
CleanEx	MM_NCOA6
Genevestigator	Q9JL19
GO	GO:0035097 GO:0005634 GO:0005667 GO:0003682 GO:0046966 GO:0003713 GO:0007420 GO:0006974 GO:0007507 GO:0060716 GO:0030099 GO:0045893 GO:0006351
InterPro	IPR026638
PANTHER	PTHR15690:SF0

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:10788465^[1]	ECO:0000314			C		Figure 3 shows that PRIP localizes to the nucleus.	complete CACAO 3669
part_of	GO:0005634	nucleus	PMID:10788465^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14686	F		Seeded From UniProt	complete
involved_in	GO:0030099	myeloid cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14686	P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14686	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000403110 RGD:620111 UniProtKB:Q14686	P		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000403110 UniProtKB:Q14686	C		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000403110 RGD:620111 UniProtKB:Q14686	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1929915 PANTHER:PTN000403110	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0080182	histone H3-K4 trimethylation	PMID:17021013^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2444959 MGI:MGI:2682319	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0080182	histone H3-K4 trimethylation	PMID:17021013^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046462	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060716	labyrinthine layer blood vessel development	PMID:12556486^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450859	P	results_in_development_of:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060716	labyrinthine layer blood vessel development	PMID:12368298^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445463	P	results_in_development_of:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12556486^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10681503^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:17500065^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14686	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:17021013^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:12556486^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:12368298^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445463	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:12556486^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:17500065^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14686	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:10681503^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10788465^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17500065^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14686	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:10788465^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:12446761^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026638	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026638	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-5619436 Reactome:R-MMU-5619434 Reactome:R-MMU-5619430 Reactome:R-MMU-5619424 Reactome:R-MMU-5619411 Reactome:R-MMU-5617990 Reactome:R-MMU-5617960 Reactome:R-MMU-6810170 Reactome:R-MMU-6810169 Reactome:R-MMU-6810150 Reactome:R-MMU-5693628 Reactome:R-MMU-5621012 Reactome:R-MMU-5621004 Reactome:R-MMU-5619441 Reactome:R-MMU-5619440 Reactome:R-MMU-5619437	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhu, Y et al. (2000) Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J. Biol. Chem. 275 13510-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Lee, S et al. (2006) Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc. Natl. Acad. Sci. U.S.A. 103 15392-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Antonson, P et al. (2003) Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol. Cell. Biol. 23 1260-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Kuang, SQ et al. (2002) Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J. Biol. Chem. 277 45356-60 PubMed GONUTS page
↑ ^6.0 ^6.1 Caira, F et al. (2000) Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275 5308-17 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
↑ Kim, SW et al. (2002) Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol. Cell. Biol. 22 8409-14 PubMed GONUTS page

[PMID:10788465-1] 1.0 ^1.1 ^1.2 ^1.3 Zhu, Y et al. (2000) Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J. Biol. Chem. 275 13510-6 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17021013-3] 3.0 ^3.1 ^3.2 Lee, S et al. (2006) Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc. Natl. Acad. Sci. U.S.A. 103 15392-7 PubMed GONUTS page

[PMID:12556486-4] 4.0 ^4.1 ^4.2 ^4.3 Antonson, P et al. (2003) Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol. Cell. Biol. 23 1260-8 PubMed GONUTS page

[PMID:12368298-5] 5.0 ^5.1 Kuang, SQ et al. (2002) Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J. Biol. Chem. 277 45356-60 PubMed GONUTS page

[PMID:10681503-6] 6.0 ^6.1 Caira, F et al. (2000) Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275 5308-17 PubMed GONUTS page

[PMID:17500065-7] 7.0 ^7.1 ^7.2 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

[PMID:12446761-8] Kim, SW et al. (2002) Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol. Cell. Biol. 22 8409-14 PubMed GONUTS page

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MOUSE:NCOA6

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