MOUSE:PO5F1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pou5f1 (synonyms: Oct-3, Oct-4, Otf-3, Otf3)
Protein Name(s)	POU domain, class 5, transcription factor 1 NF-A3 Octamer-binding protein 3 Oct-3 Octamer-binding protein 4 Oct-4 Octamer-binding transcription factor 3 OTF-3
External Links
UniProt	P20263
EMBL	M34381 X52437 S58426 S58422 S58423 S58424 S58425 BC068268
CCDS	CCDS37600.1
PIR	A34672 S17313
RefSeq	NP_038661.2
UniGene	Mm.17031
PDB	1OCP 3L1P
PDBsum	1OCP 3L1P
ProteinModelPortal	P20263
SMR	P20263
BioGrid	202313
DIP	DIP-29931N
IntAct	P20263
STRING	10090.ENSMUSP00000025271
PhosphoSite	P20263
PRIDE	P20263
Ensembl	ENSMUST00000025271
GeneID	18999
KEGG	mmu:18999
UCSC	uc008chu.2
CTD	5460
MGI	MGI:101893
eggNOG	NOG329627
GeneTree	ENSGT00760000118935
HOGENOM	HOG000089941
HOVERGEN	HBG057998
InParanoid	P20263
KO	K09367
OMA	LENMFLQ
OrthoDB	EOG7DJSMG
PhylomeDB	P20263
TreeFam	TF316413
Reactome	REACT_216222 REACT_220962
EvolutionaryTrace	P20263
NextBio	295410
PRO	PR:P20263
Proteomes	UP000000589
Bgee	P20263
CleanEx	MM_POU5F1
ExpressionAtlas	P20263
Genevestigator	P20263
GO	GO:0005737 GO:0044798 GO:0005730 GO:0005654 GO:0005634 GO:0005667 GO:0017053 GO:0003682 GO:0003677 GO:0046982 GO:0000978 GO:0001077 GO:0001105 GO:0043565 GO:0000981 GO:0003700 GO:0003714 GO:0008134 GO:0044212 GO:0031625 GO:0001824 GO:0045165 GO:0001712 GO:0001711 GO:0001714 GO:0030718 GO:0001710 GO:0042789 GO:0045955 GO:0045596 GO:0051898 GO:0000122 GO:0045892 GO:0051897 GO:0045944 GO:0045893 GO:0009786 GO:0006355 GO:0034097 GO:0010033 GO:0032526 GO:0048863 GO:0019827 GO:0006366 GO:0001829
Gene3D	1.10.10.60 1.10.260.40
InterPro	IPR017970 IPR001356 IPR009057 IPR010982 IPR013847 IPR015585 IPR000327
PANTHER	PTHR11636:SF15
Pfam	PF00046 PF00157
PRINTS	PR00028
SMART	SM00389 SM00352
SUPFAM	SSF46689 SSF47413
PROSITE	PS00027 PS50071 PS00035 PS00465 PS51179

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031625	ubiquitin protein ligase binding	PMID:15047715^[1]	ECO:0000021		UniProtKB:Q9DBH0	F		Fig 3. Wwp2 binds oct4 both in vitro and in vivo	complete
	GO:0005634	nucleus	PMID:15047715^[1]	ECO:0000314			C		fig 2b	complete
	GO:0045941	positive regulation of transcription	PMID:15047715^[1]	ECO:0000269			P		fig 6	complete
	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:26691508^[2]	ECO:0000314			F		Protein Name: Oct 4 Uniprot ID: P20263 Notes: Fig. 1C and D shows that Mouse cells treated with Oct4 (a transcription factor identified in Uniprot as Pou5f1) exhibit increased mRNA levels of the genes Wdr5 and Dpy30 relative to the control. Fig 6B shows that Oct4 binds the promoter.	complete CACAO 13344
involved_in	GO:0010629	negative regulation of gene expression	PMID:23495099^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23495099^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:23495099^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	PMID:23495099^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:23495099^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:29153991^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:29153991^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:29153991^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29153991^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:29153991^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:23376973^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	PMID:23376973^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23376973^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23376973^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:23376973^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12615074^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:22286)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:12615074^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:12615074^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	PMID:15047715^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:15047715^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9DBH0	F		Seeded From UniProt	complete
involved_in	GO:0009786	regulation of asymmetric cell division	PMID:21258368^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21076177^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P48432	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:15047715^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21076177^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18662995^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21258368^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001824	blastocyst development	PMID:21258368^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:15047715^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:23508100^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23508100^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17541407^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19816951^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60793	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17541407^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70062	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090308	regulation of methylation-dependent chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359491	F		Seeded From UniProt	complete
enables	GO:0070974	POU domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359491	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060965	negative regulation of gene silencing by miRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060913	cardiac cell fate determination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060795	cell fate commitment involved in formation of primary germ layer	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060391	positive regulation of SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048863	stem cell differentiation	PMID:20123909^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0002322)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:22344693^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045955	negative regulation of calcium ion-dependent exocytosis	PMID:2357966^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9649510^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98364	P	has_regulation_target:(MGI:MGI:98389)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7590241^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98364	P	has_regulation_target:(MGI:MGI:95518)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17507372^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17097055^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98364	P	has_regulation_target:(MGI:MGI:95518)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15863505^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98363 MGI:MGI:98364	P	has_regulation_target:(MGI:MGI:95518)\|has_regulation_target:(MGI:MGI:1354755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15988017^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:101893)\|has_regulation_target:(MGI:MGI:98364)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9649510^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:98389)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1972777^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21245162^[24]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:1967980^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:1967980^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045596	negative regulation of cell differentiation	PMID:16325584^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201683	P	regulates_o_results_in_acquisition_of_features_of:(CL:1000274)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:9814708^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1933381	P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:22344693^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9649510^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:98389)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8960364^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7969117^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7945330^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:19796622^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:96770)\|has_input:(MGI:MGI:98658)\|has_input:(MGI:MGI:98364)\|has_input:(MGI:MGI:1919200)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:18400104^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17938240^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:1690859^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16518401^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21245162^[24]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359491	F		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032526	response to retinoic acid	PMID:18400104^[32]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16039) occurs_in:(CL:0000034)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:24268575^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030718	germ-line stem cell population maintenance	PMID:15486564^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177588,MGI:MGI:3578312	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:9814708^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1933381	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:20720539^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:16767105^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:14502573^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	PMID:16325584^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:17938240^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	PMID:18400104^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	PMID:1967980^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12665572^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359491	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7958450^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000023)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23824537^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19480014^[44]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000023)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	C		Seeded From UniProt	complete
	GO:0036207	positive regulation of histone gene expression	PMID:26691508^[2]	ECO:0000314			P		Fig. 1C and D shows that Mouse cells treated with Oct4 exhibit increased mRNA levels of histone related genes Wdr5 and Actb relative to the control.	complete
part_of	GO:0005730	nucleolus	PMID:19480014^[44]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000023)	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:7969117^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	PMID:26691508^[2]	ECO:0000314			P		In Figure 1, more specifically 1C and 1D, it is shown how POU domain, class 5, transcription factor 1/Transcription Factor Oct4 in Mus musculus upregulates Wdr5 and Dpy30 expression at the RNA level. Figure 6B then shows occupation of the promoter sequence through ChIP assays for the POU domain, class 5, transcription factor 1/Transcription Factor Oct4.	complete CACAO 13461
part_of	GO:0005667	transcription factor complex	PMID:17507372^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9507072^[45]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962) part_of:(CL:0000023)\|part_of:(EMAPA:17972) part_of:(CL:0000020)\|part_of:(EMAPA:17386) part_of:(CL:0000670)\|part_of:(EMAPA:16578) part_of:(CL:0000670)\|part_of:(EMAPA:17965) part_of:(CL:0000670)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7969117^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7958450^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000023)\|part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25397698^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25335925^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24315442^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23824537^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22992956^[49]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16069)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22948967^[50]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22770845^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20720167^[52]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20336070^[53]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20123909^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19915186^[54]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18755297^[55]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18448678^[56]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18425773^[57]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17761)\|part_of:(EMAPA:17760)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18423437^[58]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16040)\|part_of:(EMAPA:16039)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18096721^[59]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16037) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17882221^[60]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17972) part_of:(CL:0000499)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17138661^[61]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16041) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16611995^[62]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16041)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16325584^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15977177^[63]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15525667^[64]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16041)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15183310^[65]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16037) part_of:(CL:0000007)\|part_of:(EMAPA:16040) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14502573^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000352)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12641567^[66]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000586)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12665572^[41]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359491	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:16325584^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359491	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:2357966^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:1972777^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:1967980^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12665572^[41]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359491	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21295276^[67]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1098693)\|has_participant:(MGI:MGI:2443298)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18467660^[68]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15988017^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:101893)\|has_participant:(MGI:MGI:98364)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15863505^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98363 MGI:MGI:98364	F	has_participant:(MGI:MGI:95518)\|has_participant:(MGI:MGI:1354755)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:1967980^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12665572^[41]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003130	BMP signaling pathway involved in heart induction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001832	blastocyst growth	PMID:24036311^[69]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001829	trophectodermal cell differentiation	PMID:16325584^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201683	P	results_in_acquisition_of_features_of:(CL:1000274)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001714	endodermal cell fate specification	PMID:21245162^[24]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001712	ectodermal cell fate commitment	PMID:10742100^[70]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_commitment_to:(CL:1000274)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001711	endodermal cell fate commitment	PMID:10742100^[70]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_commitment_to:(CL:0000223)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001710	mesodermal cell fate commitment	PMID:10742100^[70]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_commitment_to:(CL:0000222)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
enables	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	PMID:17938240^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:22344693^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16325584^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88361 MGI:MGI:88362	P	has_regulation_target:(MGI:MGI:95518)\|has_regulation_target:(MGI:MGI:1276125)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01860	P		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	F		Seeded From UniProt	complete
enables	GO:0070974	POU domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	F		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6MG27 ensembl:ENSRNOP00000065216	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	PMID:23495099^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Xu, HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J. Biol. Chem. 279 23495-503 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Campbell, PA & Rudnicki, MA (2013) Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency. Stem Cells 31 1107-20 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Bae, KB et al. (2017) Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. Stem Cell Reports 9 2050-2064 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Esch, D et al. (2013) A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat. Cell Biol. 15 295-301 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Nishimoto, M et al. (2003) The embryonic Octamer factor 3/4 displays distinct DNA binding specificity from those of other Octamer factors. Biochem. Biophys. Res. Commun. 302 581-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Plachta, N et al. (2011) Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat. Cell Biol. 13 117-23 PubMed GONUTS page
↑ ^8.0 ^8.1 Johansson, H & Simonsson, S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2 815-22 PubMed GONUTS page
↑ van den Berg, DL et al. (2008) Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol. Cell. Biol. 28 5986-95 PubMed GONUTS page
↑ ^10.0 ^10.1 Uranishi, K et al. (2013) Dax1 associates with Esrrb and regulates its function in embryonic stem cells. Mol. Cell. Biol. 33 2056-66 PubMed GONUTS page
↑ ^11.0 ^11.1 Cao, Y et al. (2007) POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J. 26 2942-54 PubMed GONUTS page
↑ Wei, Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27 2969-78 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ ^14.0 ^14.1 Niakan, KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24 312-26 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Ng, CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 40 4933-41 PubMed GONUTS page
↑ ^16.0 ^16.1 Schöler, HR et al. (1990) Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 9 2185-95 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Botquin, V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 12 2073-90 PubMed GONUTS page
↑ Yuan, H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 9 2635-45 PubMed GONUTS page
↑ ^19.0 ^19.1 Li, J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J. Biol. Chem. 282 19481-92 PubMed GONUTS page
↑ Tsuruzoe, S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem. Biophys. Res. Commun. 351 920-6 PubMed GONUTS page
↑ ^21.0 ^21.1 Maruyama, M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J. Biol. Chem. 280 24371-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Chew, JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25 6031-46 PubMed GONUTS page
↑ ^23.0 ^23.1 Rosner, MH et al. (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345 686-92 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Teo, AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 25 238-50 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 Okamoto, K et al. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60 461-72 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Niwa, H et al. (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123 917-29 PubMed GONUTS page
↑ ^27.0 ^27.1 Nichols, J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95 379-91 PubMed GONUTS page
↑ Wang, L & Schultz, GA (1996) Expression of Oct-4 during differentiation of murine F9 cells. Biochem. Cell Biol. 74 579-84 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Dailey, L et al. (1994) Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol. Cell. Biol. 14 7758-69 PubMed GONUTS page
↑ Rosfjord, E & Rizzino, A (1994) The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Biochem. Biophys. Res. Commun. 203 1795-802 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 Kunarso, G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9 155 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 Loh, YH et al. (2007) Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev. 21 2545-57 PubMed GONUTS page
↑ Schöler, HR et al. (1990) New type of POU domain in germ line-specific protein Oct-4. Nature 344 435-9 PubMed GONUTS page
↑ Loh, YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38 431-40 PubMed GONUTS page
↑ Payer, B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol. Cell 52 805-18 PubMed GONUTS page
↑ Kehler, J et al. (2004) Oct4 is required for primordial germ cell survival. EMBO Rep. 5 1078-83 PubMed GONUTS page
↑ Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page
↑ Ivanova, N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442 533-8 PubMed GONUTS page
↑ ^40.0 ^40.1 Velkey, JM & O'Shea, KS (2003) Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. Genesis 37 18-24 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 ^41.3 Tokuzawa, Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23 2699-708 PubMed GONUTS page
↑ ^42.0 ^42.1 Palmieri, SL et al. (1994) Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev. Biol. 166 259-67 PubMed GONUTS page
↑ ^43.0 ^43.1 Lorthongpanich, C et al. (2013) Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes Dev. 27 1441-6 PubMed GONUTS page
↑ ^44.0 ^44.1 Monti, M & Redi, C (2009) Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development. Mol. Reprod. Dev. 76 994-1003 PubMed GONUTS page
↑ Pesce, M et al. (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech. Dev. 71 89-98 PubMed GONUTS page
↑ Wang, C et al. (2015) Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos. Stem Cells Dev. 24 904-15 PubMed GONUTS page
↑ Shen, J et al. (2015) Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells 33 661-73 PubMed GONUTS page
↑ Wang, L et al. (2013) The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell 13 676-90 PubMed GONUTS page
↑ Iwafuchi-Doi, M et al. (2012) Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development 139 3926-37 PubMed GONUTS page
↑ Turco, MY et al. (2012) Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein. Stem Cells 30 2423-36 PubMed GONUTS page
↑ Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page
↑ Ma, P et al. (2010) Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol. Reprod. 83 1027-35 PubMed GONUTS page
↑ Zalzman, M et al. (2010) Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 464 858-63 PubMed GONUTS page
↑ Yamada, M et al. (2010) Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. Hum. Mol. Genet. 19 480-93 PubMed GONUTS page
↑ Brown, L & Brown, S (2009) Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with makers of neurogenesis. Gene Expr. Patterns 9 43-9 PubMed GONUTS page
↑ Gao, X et al. (2008) ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc. Natl. Acad. Sci. U.S.A. 105 6656-61 PubMed GONUTS page
↑ Strizzi, L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J. Cell. Physiol. 216 824-34 PubMed GONUTS page
↑ Wang, H et al. (2008) Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev. Biol. 318 112-25 PubMed GONUTS page
↑ Kuntz, S et al. (2008) Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. Stem Cells 26 734-44 PubMed GONUTS page
↑ Seandel, M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449 346-50 PubMed GONUTS page
↑ Kan, NG et al. (2007) Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134 31-41 PubMed GONUTS page
↑ Cormier, S et al. (2006) The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Mol. Cell. Biol. 26 3541-9 PubMed GONUTS page
↑ Barrow, KM et al. (2005) Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev. Dyn. 233 1535-45 PubMed GONUTS page
↑ Kemler, R et al. (2004) Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131 5817-24 PubMed GONUTS page
↑ Liu, L et al. (2004) Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos. Gene Expr. Patterns 4 433-41 PubMed GONUTS page
↑ Durcova-Hills, G et al. (2003) Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro. Differentiation 71 135-41 PubMed GONUTS page
↑ Koh, KP et al. (2011) Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8 200-13 PubMed GONUTS page
↑ Tam, WL et al. (2008) T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells 26 2019-31 PubMed GONUTS page
↑ Zhang, K et al. (2013) CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev. Biol. 383 15-27 PubMed GONUTS page
↑ ^70.0 ^70.1 ^70.2 Niwa, H et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24 372-6 PubMed GONUTS page

[PMID:15047715-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Xu, HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J. Biol. Chem. 279 23495-503 PubMed GONUTS page

[PMID:26691508-2] 2.0 ^2.1 ^2.2 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page

[PMID:23495099-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Campbell, PA & Rudnicki, MA (2013) Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency. Stem Cells 31 1107-20 PubMed GONUTS page

[PMID:29153991-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Bae, KB et al. (2017) Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. Stem Cell Reports 9 2050-2064 PubMed GONUTS page

[PMID:23376973-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Esch, D et al. (2013) A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat. Cell Biol. 15 295-301 PubMed GONUTS page

[PMID:12615074-6] 6.0 ^6.1 ^6.2 Nishimoto, M et al. (2003) The embryonic Octamer factor 3/4 displays distinct DNA binding specificity from those of other Octamer factors. Biochem. Biophys. Res. Commun. 302 581-6 PubMed GONUTS page

[PMID:21258368-7] 7.0 ^7.1 ^7.2 Plachta, N et al. (2011) Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat. Cell Biol. 13 117-23 PubMed GONUTS page

[PMID:21076177-8] 8.0 ^8.1 Johansson, H & Simonsson, S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2 815-22 PubMed GONUTS page

[PMID:18662995-9] van den Berg, DL et al. (2008) Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol. Cell. Biol. 28 5986-95 PubMed GONUTS page

[PMID:23508100-10] 10.0 ^10.1 Uranishi, K et al. (2013) Dax1 associates with Esrrb and regulates its function in embryonic stem cells. Mol. Cell. Biol. 33 2056-66 PubMed GONUTS page

[PMID:17541407-11] 11.0 ^11.1 Cao, Y et al. (2007) POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J. 26 2942-54 PubMed GONUTS page

[PMID:19816951-12] Wei, Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27 2969-78 PubMed GONUTS page

[PMID:20439489-13] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:20123909-14] 14.0 ^14.1 Niakan, KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 24 312-26 PubMed GONUTS page

[PMID:22344693-15] 15.0 ^15.1 ^15.2 Ng, CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 40 4933-41 PubMed GONUTS page

[PMID:2357966-16] 16.0 ^16.1 Schöler, HR et al. (1990) Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 9 2185-95 PubMed GONUTS page

[PMID:9649510-17] 17.0 ^17.1 ^17.2 Botquin, V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 12 2073-90 PubMed GONUTS page

[PMID:7590241-18] Yuan, H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 9 2635-45 PubMed GONUTS page

[PMID:17507372-19] 19.0 ^19.1 Li, J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J. Biol. Chem. 282 19481-92 PubMed GONUTS page

[PMID:17097055-20] Tsuruzoe, S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem. Biophys. Res. Commun. 351 920-6 PubMed GONUTS page

[PMID:15863505-21] 21.0 ^21.1 Maruyama, M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J. Biol. Chem. 280 24371-9 PubMed GONUTS page

[PMID:15988017-22] 22.0 ^22.1 Chew, JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25 6031-46 PubMed GONUTS page

[PMID:1972777-23] 23.0 ^23.1 Rosner, MH et al. (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345 686-92 PubMed GONUTS page

[PMID:21245162-24] 24.0 ^24.1 ^24.2 Teo, AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 25 238-50 PubMed GONUTS page

[PMID:1967980-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 Okamoto, K et al. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60 461-72 PubMed GONUTS page

[PMID:16325584-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Niwa, H et al. (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123 917-29 PubMed GONUTS page

[PMID:9814708-27] 27.0 ^27.1 Nichols, J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95 379-91 PubMed GONUTS page

[PMID:8960364-28] Wang, L & Schultz, GA (1996) Expression of Oct-4 during differentiation of murine F9 cells. Biochem. Cell Biol. 74 579-84 PubMed GONUTS page

[PMID:7969117-29] 29.0 ^29.1 ^29.2 Dailey, L et al. (1994) Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol. Cell. Biol. 14 7758-69 PubMed GONUTS page

[PMID:7945330-30] Rosfjord, E & Rizzino, A (1994) The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Biochem. Biophys. Res. Commun. 203 1795-802 PubMed GONUTS page

[PMID:19796622-31] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:18400104-32] 32.0 ^32.1 ^32.2 Kunarso, G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9 155 PubMed GONUTS page

[PMID:17938240-33] 33.0 ^33.1 ^33.2 Loh, YH et al. (2007) Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev. 21 2545-57 PubMed GONUTS page

[PMID:1690859-34] Schöler, HR et al. (1990) New type of POU domain in germ line-specific protein Oct-4. Nature 344 435-9 PubMed GONUTS page

[PMID:16518401-35] Loh, YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38 431-40 PubMed GONUTS page

[PMID:24268575-36] Payer, B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol. Cell 52 805-18 PubMed GONUTS page

[PMID:15486564-37] Kehler, J et al. (2004) Oct4 is required for primordial germ cell survival. EMBO Rep. 5 1078-83 PubMed GONUTS page

[PMID:20720539-38] Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page

[PMID:16767105-39] Ivanova, N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442 533-8 PubMed GONUTS page

[PMID:14502573-40] 40.0 ^40.1 Velkey, JM & O'Shea, KS (2003) Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. Genesis 37 18-24 PubMed GONUTS page

[PMID:12665572-41] 41.0 ^41.1 ^41.2 ^41.3 Tokuzawa, Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23 2699-708 PubMed GONUTS page

[PMID:7958450-42] 42.0 ^42.1 Palmieri, SL et al. (1994) Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev. Biol. 166 259-67 PubMed GONUTS page

[PMID:23824537-43] 43.0 ^43.1 Lorthongpanich, C et al. (2013) Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes Dev. 27 1441-6 PubMed GONUTS page

[PMID:19480014-44] 44.0 ^44.1 Monti, M & Redi, C (2009) Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development. Mol. Reprod. Dev. 76 994-1003 PubMed GONUTS page

[PMID:9507072-45] Pesce, M et al. (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech. Dev. 71 89-98 PubMed GONUTS page

[PMID:25397698-46] Wang, C et al. (2015) Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos. Stem Cells Dev. 24 904-15 PubMed GONUTS page

[PMID:25335925-47] Shen, J et al. (2015) Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells 33 661-73 PubMed GONUTS page

[PMID:24315442-48] Wang, L et al. (2013) The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell 13 676-90 PubMed GONUTS page

[PMID:22992956-49] Iwafuchi-Doi, M et al. (2012) Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development 139 3926-37 PubMed GONUTS page

[PMID:22948967-50] Turco, MY et al. (2012) Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein. Stem Cells 30 2423-36 PubMed GONUTS page

[PMID:22770845-51] Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page

[PMID:20720167-52] Ma, P et al. (2010) Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol. Reprod. 83 1027-35 PubMed GONUTS page

[PMID:20336070-53] Zalzman, M et al. (2010) Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 464 858-63 PubMed GONUTS page

[PMID:19915186-54] Yamada, M et al. (2010) Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. Hum. Mol. Genet. 19 480-93 PubMed GONUTS page

[PMID:18755297-55] Brown, L & Brown, S (2009) Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with makers of neurogenesis. Gene Expr. Patterns 9 43-9 PubMed GONUTS page

[PMID:18448678-56] Gao, X et al. (2008) ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc. Natl. Acad. Sci. U.S.A. 105 6656-61 PubMed GONUTS page

[PMID:18425773-57] Strizzi, L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J. Cell. Physiol. 216 824-34 PubMed GONUTS page

[PMID:18423437-58] Wang, H et al. (2008) Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev. Biol. 318 112-25 PubMed GONUTS page

[PMID:18096721-59] Kuntz, S et al. (2008) Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. Stem Cells 26 734-44 PubMed GONUTS page

[PMID:17882221-60] Seandel, M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449 346-50 PubMed GONUTS page

[PMID:17138661-61] Kan, NG et al. (2007) Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134 31-41 PubMed GONUTS page

[PMID:16611995-62] Cormier, S et al. (2006) The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Mol. Cell. Biol. 26 3541-9 PubMed GONUTS page

[PMID:15977177-63] Barrow, KM et al. (2005) Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev. Dyn. 233 1535-45 PubMed GONUTS page

[PMID:15525667-64] Kemler, R et al. (2004) Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131 5817-24 PubMed GONUTS page

[PMID:15183310-65] Liu, L et al. (2004) Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos. Gene Expr. Patterns 4 433-41 PubMed GONUTS page

[PMID:12641567-66] Durcova-Hills, G et al. (2003) Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro. Differentiation 71 135-41 PubMed GONUTS page

[PMID:21295276-67] Koh, KP et al. (2011) Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8 200-13 PubMed GONUTS page

[PMID:18467660-68] Tam, WL et al. (2008) T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells 26 2019-31 PubMed GONUTS page

[PMID:24036311-69] Zhang, K et al. (2013) CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev. Biol. 383 15-27 PubMed GONUTS page

[PMID:10742100-70] 70.0 ^70.1 ^70.2 Niwa, H et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24 372-6 PubMed GONUTS page

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[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

[54]

[55]

[56]

[57]

[58]

[59]

[60]

[61]

[62]

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[64]

[65]

[66]

[67]

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