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PMID:1972777
| Citation |
Rosner, MH, Vigano, MA, Ozato, K, Timmons, PM, Poirier, F, Rigby, PW and Staudt, LM (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345:686-92 |
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| Abstract |
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line. |
| Links |
PubMed Online version:10.1038/345686a0 |
| Keywords |
Amino Acid Sequence; Base Sequence; Cell Differentiation; DNA-Binding Proteins/genetics; Down-Regulation; Embryo, Mammalian/metabolism; Embryo, Nonmammalian; Endoderm/cytology; Gene Expression; Genes, Homeobox; Germ Cells/metabolism; Mesoderm/cytology; Molecular Sequence Data; Nucleic Acid Hybridization; Octamer Transcription Factor-3; Oocytes/growth & development; Oocytes/metabolism; RNA, Messenger/analysis; RNA, Messenger/genetics; Stem Cells/metabolism; Transcription Factors/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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