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PMID:9507072
| Citation |
Pesce, M, Wang, X, Wolgemuth, DJ and Schöler, H (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech. Dev. 71:89-98 |
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| Abstract |
The POU transcription factor Oct-4 is expressed in early mouse embryogenesis and in pluripotent ES and EC stem cell lines. After gastrulation in the embryo, Oct-4 expression is confined to the germline. The present study provides evidence that Oct-4 undergoes downregulation during oogenesis and spermatogenesis, coincident with entry into meiosis. Furthermore, analysis of maturation stages of oocytes showed that Oct-4 is upregulated de novo in the final stages of meiotic prophase I in female germ cells. These data suggest that Oct-4 downregulation in germ cells in both sexes might represent one of the molecular triggers involved in the commitment to meiosis. The upregulation of Oct-4 in oocytes at the completion of the prophase I of meiotic division further suggests a specific involvement of this transcription factor in oocyte growth or the acquisition of meiotic competence. |
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| Keywords |
Animals; Cell Differentiation/genetics; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; Down-Regulation/genetics; Female; Gene Expression Regulation, Developmental; Germ Cells/cytology; Male; Mice; Octamer Transcription Factor-3; Spermatogonia/cytology; Spermatogonia/metabolism; Transcription Factors/biosynthesis; Transcription Factors/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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