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HUMAN:AIP
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | AIP (synonyms: XAP2) | |
| Protein Name(s) | AH receptor-interacting protein
AIP Aryl-hydrocarbon receptor-interacting protein HBV X-associated protein 2 XAP-2 Immunophilin homolog ARA9 | |
| External Links | ||
| UniProt | O00170 | |
| EMBL | U31913 U78521 AM236341 EF066502 EF066504 EF066505 EF066510 BC104827 BC104797 | |
| CCDS | CCDS8168.1 | |
| RefSeq | NP_003968.2 | |
| UniGene | Hs.412433 | |
| PDB | 2LKN 4AIF 4APO | |
| PDBsum | 2LKN 4AIF 4APO | |
| ProteinModelPortal | O00170 | |
| SMR | O00170 | |
| BioGrid | 114511 | |
| DIP | DIP-34068N | |
| IntAct | O00170 | |
| MINT | MINT-5000425 | |
| STRING | 9606.ENSP00000279146 | |
| PhosphoSite | O00170 | |
| MaxQB | O00170 | |
| PaxDb | O00170 | |
| PRIDE | O00170 | |
| Ensembl | ENST00000279146 | |
| GeneID | 9049 | |
| KEGG | hsa:9049 | |
| UCSC | uc001olv.3 | |
| CTD | 9049 | |
| GeneCards | GC11P067251 | |
| GeneReviews | AIP | |
| HGNC | HGNC:358 | |
| HPA | HPA004063 HPA050217 | |
| MIM | 102200 219090 600634 605555 | |
| neXtProt | NX_O00170 | |
| Orphanet | 963 314777 | |
| PharmGKB | PA24652 | |
| eggNOG | NOG250378 | |
| HOVERGEN | HBG004198 | |
| InParanoid | O00170 | |
| KO | K17767 | |
| OMA | IVCTMRE | |
| PhylomeDB | O00170 | |
| TreeFam | TF314507 | |
| GeneWiki | AH_receptor-interacting_protein | |
| GenomeRNAi | 9049 | |
| NextBio | 33903 | |
| PRO | PR:O00170 | |
| Proteomes | UP000005640 | |
| Bgee | O00170 | |
| CleanEx | HS_AIP | |
| ExpressionAtlas | O00170 | |
| Genevestigator | O00170 | |
| GO | GO:0005737 GO:0005829 GO:0016020 GO:0005634 GO:0036004 GO:0004871 GO:0003713 GO:0008134 GO:0051082 GO:0051344 GO:0022417 GO:0006626 GO:1903506 GO:0010738 GO:0007165 GO:0006805 | |
| Gene3D | 1.25.40.10 | |
| InterPro | IPR001179 IPR013026 IPR011990 IPR019734 | |
| Pfam | PF00254 | |
| PROSITE | PS50059 PS50005 PS50293 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0051082 |
unfolded protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022417 |
protein maturation by protein folding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006626 |
protein targeting to mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036004 |
GAF domain binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903506 |
regulation of nucleic acid-templated transcription |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003712 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903508 |
positive regulation of nucleic acid-templated transcription |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0003713 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034751 |
aryl hydrocarbon receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08915 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017162 |
aryl hydrocarbon receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08915 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08915 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08915 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08915 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003712 |
transcription coregulator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08915 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051344 |
negative regulation of cyclic-nucleotide phosphodiesterase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5FWY5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010738 |
regulation of protein kinase A signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5FWY5 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5FWY5 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
PMID:14557246[1] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0035722 |
interleukin-12-mediated signaling pathway |
Reactome:R-HSA-9020591 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
Reactome:R-HSA-211945 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8937191 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Yano, M et al. (2003) AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. J. Cell Biol. 163 45-56 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 de Oliveira, SK et al. (2007) Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. J. Biol. Chem. 282 13656-63 PubMed GONUTS page
- ↑ 3.0 3.1 Meyer, BK et al. (1998) Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol. Cell. Biol. 18 978-88 PubMed GONUTS page
- ↑ Kuzhandaivelu, N et al. (1996) XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. Nucleic Acids Res. 24 4741-50 PubMed GONUTS page
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