HUMAN:GATA3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GATA3
Protein Name(s)	Trans-acting T-cell-specific transcription factor GATA-3 GATA-binding factor 3
External Links
UniProt	P23771
EMBL	X58072 X55037 X55122 M69106 AY497006 AL390294 AL390294 CH471072 CH471072 BC003070 BC006793
CCDS	CCDS31143.1 CCDS7083.1
PIR	A39794
RefSeq	NP_001002295.1 NP_002042.1 XP_005252499.1 XP_005252500.1
UniGene	Hs.524134
PDB	4HC7 4HC9 4HCA
PDBsum	4HC7 4HC9 4HCA
ProteinModelPortal	P23771
SMR	P23771
BioGrid	108895
IntAct	P23771
MINT	MINT-4721003
STRING	9606.ENSP00000368632
PhosphoSite	P23771
DMDM	120962
MaxQB	P23771
PaxDb	P23771
PRIDE	P23771
DNASU	2625
Ensembl	ENST00000346208 ENST00000379328
GeneID	2625
KEGG	hsa:2625
UCSC	uc001ijz.3 uc001ika.3
CTD	2625
GeneCards	GC10P008095
HGNC	HGNC:4172
HPA	HPA029730 HPA029731
MIM	131320 146255
neXtProt	NX_P23771
Orphanet	2237 99860
PharmGKB	PA28586
eggNOG	COG5641
GeneTree	ENSGT00760000119221
HOGENOM	HOG000047701
HOVERGEN	HBG051705
InParanoid	P23771
KO	K17895
OMA	QRYPPTH
OrthoDB	EOG7CCBRF
PhylomeDB	P23771
TreeFam	TF315391
Reactome	REACT_24970
SignaLink	P23771
GeneWiki	GATA3
GenomeRNAi	2625
NextBio	10339
PRO	PR:P23771
Proteomes	UP000005640
Bgee	P23771
CleanEx	HS_GATA3
Genevestigator	P23771
GO	GO:0000790 GO:0005730 GO:0005654 GO:0005634 GO:0000987 GO:0001046 GO:0003677 GO:0070888 GO:0001158 GO:0071837 GO:0001071 GO:0001078 GO:0001077 GO:0000979 GO:0003700 GO:0003713 GO:0008134 GO:0044212 GO:0000976 GO:0008270 GO:0048646 GO:0009653 GO:0003180 GO:0007411 GO:0007596 GO:0061290 GO:0003215 GO:0001709 GO:0048469 GO:0071773 GO:0035457 GO:0071353 GO:0071356 GO:0006952 GO:0048589 GO:0043583 GO:0035162 GO:0030218 GO:0006959 GO:0001701 GO:0045087 GO:0042472 GO:0072643 GO:0072602 GO:0001822 GO:0002088 GO:0072676 GO:0008584 GO:0060374 GO:0060231 GO:0001823 GO:0045786 GO:2000146 GO:0008285 GO:2000607 GO:2000352 GO:0045599 GO:2000703 GO:2000734 GO:0050728 GO:0032689 GO:0032703 GO:0033600 GO:0045892 GO:0072179 GO:0072178 GO:0001764 GO:0042421 GO:0071599 GO:0060017 GO:0035898 GO:0060037 GO:0014065 GO:0010595 GO:2000667 GO:0032753 GO:2000664 GO:0051897 GO:0009967 GO:0045582 GO:2000611 GO:0045944 GO:2000679 GO:0045893 GO:0072107 GO:0009791 GO:0002572 GO:0043370 GO:2000683 GO:0042035 GO:2000114 GO:0061085 GO:0051569 GO:0072182 GO:0043523 GO:0010975 GO:0042493 GO:0043627 GO:0045471 GO:0010332 GO:0009615 GO:0007165 GO:0048485 GO:0050852 GO:0045064 GO:0045061 GO:0048538 GO:0031929 GO:0006366 GO:0001806 GO:0035799 GO:0060676 GO:0060065 GO:0003281
Gene3D	3.30.50.10
InterPro	IPR029521 IPR016374 IPR000679 IPR013088
PANTHER	PTHR10071:SF106
Pfam	PF00320
PIRSF	PIRSF003027
PRINTS	PR00619
SMART	SM00401
PROSITE	PS00344 PS50114

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0070888	E-box binding	PMID:20855495^[1]	ECO:0000314			F		using oligonucleotides that cover all E-boxes and GATA binding sites present in the −875/−570 human NKX3.1 promoter region, we found that TAL1 and GATA-3 can bind an E-box located at −738 and/or two GATA binding sites at −748 and −697 (Fig. 3 c)	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000679 InterPro:IPR016374	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P17679	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20855495^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15016828^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q03014	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:2000683	regulation of cellular response to X-ray	PMID:19735555^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:20368097^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000667	positive regulation of interleukin-13 secretion	PMID:20368097^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000667	positive regulation of interleukin-13 secretion	PMID:20554961^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000664	positive regulation of interleukin-5 secretion	PMID:20554961^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000611	positive regulation of thyroid hormone generation	PMID:19248180^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000611	positive regulation of thyroid hormone generation	PMID:19723756^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000607	negative regulation of cell proliferation involved in mesonephros development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000146	negative regulation of cell motility	PMID:20189993^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072676	lymphocyte migration	PMID:19805038^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072182	regulation of nephron tubule epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0072179	nephric duct formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0072178	nephric duct morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0072107	positive regulation of ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	PMID:18445004^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:19674970^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071353	cellular response to interleukin-4	PMID:20554961^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0060676	ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0060231	mesenchymal to epithelial transition	PMID:20189993^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0048485	sympathetic nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20189993^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19232384^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20484083^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20368097^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19723756^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19805038^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	PMID:20189993^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:20705609^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19735555^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19805038^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20189993^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20484083^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:10037815^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	PMID:19248180^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	PMID:19723756^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0042035	regulation of cytokine biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0035457	cellular response to interferon-alpha	PMID:20554961^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	PMID:19483726^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:20583921^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20189993^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19723756^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19674970^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:20484083^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003281	ventricular septum development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:19248180^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:19723756^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:20368097^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19674970^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19805038^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:20189993^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19232384^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:19674970^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:19232384^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:19723756^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228 ZFIN:ZDB-GENE-990415-82	P		Seeded From UniProt	complete
involved_in	GO:0030856	regulation of epithelial cell differentiation	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 FB:FBgn0032223 FB:FBgn0038391 MGI:MGI:107516 MGI:MGI:109497 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 RGD:2663 RGD:2664 RGD:2665 RGD:2666 RGD:621250 SGD:S000000842 SGD:S000001742 SGD:S000001873 SGD:S000003646 UniProtKB:E1C9C6 UniProtKB:I3LUZ9 UniProtKB:P15976 UniProtKB:P17429 UniProtKB:P23769 UniProtKB:P23771 UniProtKB:P43691 UniProtKB:P43692 UniProtKB:P43694 UniProtKB:Q92908 UniProtKB:Q9BWX5 WB:WBGene00001186 WB:WBGene00001249 WB:WBGene00001250 WB:WBGene00001251 WB:WBGene00001252 WB:WBGene00001253 WB:WBGene00001310 WB:WBGene00001311 WB:WBGene00015981 ZFIN:ZDB-GENE-980526-340	C		Seeded From UniProt	complete
involved_in	GO:0002520	immune system development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 MGI:MGI:95661 MGI:MGI:95664 PANTHER:PTN001600628 RGD:2665 SGD:S000001742 SGD:S000003646 UniProtKB:P23769 UniProtKB:P43694 UniProtKB:Q92908 WB:WBGene00001249 WB:WBGene00001310	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107516 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 SGD:S000000842 UniProtKB:P15976 UniProtKB:P23771	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22529382^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:2000607	negative regulation of cell proliferation involved in mesonephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:1901536	negative regulation of DNA demethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0072643	interferon-gamma secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0072602	interleukin-4 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0072197	ureter morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0072182	regulation of nephron tubule epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0072179	nephric duct formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0072178	nephric duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0072107	positive regulation of ureteric bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0071599	otic vesicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0071442	positive regulation of histone H3-K14 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0071353	cellular response to interleukin-4	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0061085	regulation of histone H3-K27 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0060676	ureteric bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0060374	mast cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0060017	parathyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0051569	regulation of histone H3-K4 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0048872	homeostasis of number of cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0048485	sympathetic nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0045064	T-helper 2 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0045061	thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0042035	regulation of cytokine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0035898	parathyroid hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0035799	ureter maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0032754	positive regulation of interleukin-5 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0032736	positive regulation of interleukin-13 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	C		Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
involved_in	GO:0003281	ventricular septum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0002572	pro-T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0001775	cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	F		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23772 ensembl:ENSMUSP00000100041	P		Seeded From UniProt	complete
involved_in	GO:0090102	cochlea development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	F		Seeded From UniProt	complete
involved_in	GO:0001806	type IV hypersensitivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039355	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088 InterPro:IPR039355	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679	F		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:10935639^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:7592673^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:1871134^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8088776^[24] PMID:2050118^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:1871134^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-996755 Reactome:R-HSA-9038163 Reactome:R-HSA-9023861 Reactome:R-HSA-9023860 Reactome:R-HSA-9018499 Reactome:R-HSA-9018494 Reactome:R-HSA-9009541 Reactome:R-HSA-9009536 Reactome:R-HSA-9009533 Reactome:R-HSA-9009526 Reactome:R-HSA-9009371 Reactome:R-HSA-9009065 Reactome:R-HSA-8956586 Reactome:R-HSA-8956568 Reactome:R-HSA-6793975 Reactome:R-HSA-6783177	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kusy, S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J. Exp. Med. 207 2141-56 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Minami, T et al. (2004) Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. J. Biol. Chem. 279 20626-35 PubMed GONUTS page
↑ ^4.0 ^4.1 Bonin, F et al. (2009) GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes. BMC Genomics 10 417 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Yao, X et al. (2010) GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Chin. Med. J. 123 739-44 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Huber, JP et al. (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J. Immunol. 185 813-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Ferraris, S et al. (2009) HDR syndrome: a novel "de novo" mutation in GATA3 gene. Am. J. Med. Genet. A 149A 770-5 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaynor, KU et al. (2009) A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. J. Clin. Endocrinol. Metab. 94 3897-904 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Song, H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem. 284 29109-24 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Yan, W et al. (2010) GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. J. Biol. Chem. 285 14042-51 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Jenner, RG et al. (2009) The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc. Natl. Acad. Sci. U.S.A. 106 17876-81 PubMed GONUTS page
↑ Hossain, MB et al. (2008) Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells. Immunology 125 377-86 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Son, do N et al. (2009) Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3. Gene 436 121-7 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Nakata, Y et al. (2010) c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood 116 1280-90 PubMed GONUTS page
↑ Jack, BH & Crossley, M (2010) GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J. Biol. Chem. 285 32405-14 PubMed GONUTS page
↑ Yang, GP et al. (1999) Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 27 1517-23 PubMed GONUTS page
↑ Dydensborg, AB et al. (2009) GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Oncogene 28 2634-42 PubMed GONUTS page
↑ Díaz, YR et al. (2010) T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species. J. Infect. Dis. 202 406-15 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Home, P et al. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. U.S.A. 109 7362-7 PubMed GONUTS page
↑ Van Esch, H et al. (2000) GATA3 haplo-insufficiency causes human HDR syndrome. Nature 406 419-22 PubMed GONUTS page
↑ Siegel, MD et al. (1995) Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements. J. Biol. Chem. 270 24548-55 PubMed GONUTS page
↑ ^23.0 ^23.1 Marine, J & Winoto, A (1991) The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proc. Natl. Acad. Sci. U.S.A. 88 7284-8 PubMed GONUTS page
↑ Labastie, MC et al. (1994) Structure and expression of the human GATA3 gene. Genomics 21 1-6 PubMed GONUTS page
↑ Joulin, V et al. (1991) A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 10 1809-16 PubMed GONUTS page

[PMID:20855495-1] 1.0 ^1.1 ^1.2 ^1.3 Kusy, S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J. Exp. Med. 207 2141-56 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:15016828-3] Minami, T et al. (2004) Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. J. Biol. Chem. 279 20626-35 PubMed GONUTS page

[PMID:19735555-4] 4.0 ^4.1 Bonin, F et al. (2009) GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes. BMC Genomics 10 417 PubMed GONUTS page

[PMID:20368097-5] 5.0 ^5.1 ^5.2 ^5.3 Yao, X et al. (2010) GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Chin. Med. J. 123 739-44 PubMed GONUTS page

[PMID:20554961-6] 6.0 ^6.1 ^6.2 ^6.3 Huber, JP et al. (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J. Immunol. 185 813-7 PubMed GONUTS page

[PMID:19248180-7] 7.0 ^7.1 ^7.2 Ferraris, S et al. (2009) HDR syndrome: a novel "de novo" mutation in GATA3 gene. Am. J. Med. Genet. A 149A 770-5 PubMed GONUTS page

[PMID:19723756-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaynor, KU et al. (2009) A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. J. Clin. Endocrinol. Metab. 94 3897-904 PubMed GONUTS page

[PMID:19674970-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Song, H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem. 284 29109-24 PubMed GONUTS page

[PMID:20189993-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Yan, W et al. (2010) GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. J. Biol. Chem. 285 14042-51 PubMed GONUTS page

[PMID:19805038-11] 11.0 ^11.1 ^11.2 ^11.3 Jenner, RG et al. (2009) The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc. Natl. Acad. Sci. U.S.A. 106 17876-81 PubMed GONUTS page

[PMID:18445004-12] Hossain, MB et al. (2008) Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells. Immunology 125 377-86 PubMed GONUTS page

[PMID:19232384-13] 13.0 ^13.1 ^13.2 Son, do N et al. (2009) Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3. Gene 436 121-7 PubMed GONUTS page

[PMID:20484083-14] 14.0 ^14.1 ^14.2 Nakata, Y et al. (2010) c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood 116 1280-90 PubMed GONUTS page

[PMID:20705609-15] Jack, BH & Crossley, M (2010) GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J. Biol. Chem. 285 32405-14 PubMed GONUTS page

[PMID:10037815-16] Yang, GP et al. (1999) Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 27 1517-23 PubMed GONUTS page

[PMID:19483726-17] Dydensborg, AB et al. (2009) GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Oncogene 28 2634-42 PubMed GONUTS page

[PMID:20583921-18] Díaz, YR et al. (2010) T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species. J. Infect. Dis. 202 406-15 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22529382-20] Home, P et al. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. U.S.A. 109 7362-7 PubMed GONUTS page

[PMID:10935639-21] Van Esch, H et al. (2000) GATA3 haplo-insufficiency causes human HDR syndrome. Nature 406 419-22 PubMed GONUTS page

[PMID:7592673-22] Siegel, MD et al. (1995) Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements. J. Biol. Chem. 270 24548-55 PubMed GONUTS page

[PMID:1871134-23] 23.0 ^23.1 Marine, J & Winoto, A (1991) The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proc. Natl. Acad. Sci. U.S.A. 88 7284-8 PubMed GONUTS page

[PMID:8088776-24] Labastie, MC et al. (1994) Structure and expression of the human GATA3 gene. Genomics 21 1-6 PubMed GONUTS page

[PMID:2050118-25] Joulin, V et al. (1991) A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 10 1809-16 PubMed GONUTS page

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