MOUSE:CEBPA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cebpa
Protein Name(s)	CCAAT/enhancer-binding protein alpha C/EBP alpha
External Links
UniProt	P53566
EMBL	M62362 BC011118 BC028890 BC051102 BC058161
CCDS	CCDS21145.1
PIR	I49575
RefSeq	NP_031704.2
UniGene	Mm.349667
ProteinModelPortal	P53566
SMR	P53566
BioGrid	198667
DIP	DIP-44054N
IntAct	P53566
MINT	MINT-1529126
PhosphoSite	P53566
PaxDb	P53566
PRIDE	P53566
Ensembl	ENSMUST00000042985
GeneID	12606
KEGG	mmu:12606
UCSC	uc009gjl.2
CTD	1050
MGI	MGI:99480
eggNOG	NOG244516
GeneTree	ENSGT00530000063192
HOGENOM	HOG000013112
HOVERGEN	HBG050879
InParanoid	P53566
KO	K09055
OMA	PPPGYGC
OrthoDB	EOG7R56TQ
PhylomeDB	P53566
TreeFam	TF105008
Reactome	REACT_252217 REACT_27166
NextBio	281750
PRO	PR:P53566
Proteomes	UP000000589
Bgee	P53566
CleanEx	MM_CEBPA
Genevestigator	P53566
GO	GO:0016363 GO:0005654 GO:0005634 GO:0035189 GO:0005667 GO:0003677 GO:0042803 GO:0000978 GO:0001077 GO:0003705 GO:0001228 GO:0003700 GO:0008134 GO:0044212 GO:0006953 GO:0050873 GO:0048469 GO:0071285 GO:0071407 GO:0008203 GO:0019221 GO:0001892 GO:0045444 GO:0048839 GO:0001889 GO:0030324 GO:0030225 GO:0007005 GO:0030099 GO:0008285 GO:0000122 GO:0031100 GO:0045600 GO:0045669 GO:0045944 GO:0045945 GO:0045893 GO:0042127 GO:0006357 GO:0006355 GO:0051384 GO:0033274 GO:0006366 GO:0006351 GO:0000050 GO:0050872
InterPro	IPR004827 IPR016468
Pfam	PF07716
PIRSF	PIRSF005879
SMART	SM00338
PROSITE	PS50217

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006631	fatty acid metabolic process	PMID:24691027^[1]	ECO:0000314			P		Figure 8. Oxidative metabolism is impaired in the skeletal muscle of chow-fed MαKO mice. Skeletal muscle (quadriceps) was collected from 6-7 months old, chow-fed mice after overnight fasting. The expression of genes related to FA oxidation, muscle types, and energy expenditure were measured by Q-PCR (n=5 per group) (a). Proteins related to FA oxidation in skeletal muscle were measured by Western blotting.	complete CACAO 9818
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:21131957^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	PMID:21131957^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002476)	Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:1935900^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:8798745^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	PMID:8798745^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:8798745^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030851	granulocyte differentiation	PMID:15589173^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:14660596^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:11672531^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11672531^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030851	granulocyte differentiation	PMID:11672531^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:11672531^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:11672531^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11672531^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:17290224^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17290224^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WTN3	F		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:17290224^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	PMID:15107404^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:15107404^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P30285	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:15107404^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97377	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17090532^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17090532^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9R1E0	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10233885^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:1441)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:10233885^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:10233885^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030099	myeloid cell differentiation	PMID:15664994^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:15664994^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:15664994^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:7575576^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15664994^[12]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000144	positive regulation of DNA-templated transcription, initiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	C		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:12055200^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	PMID:1618860^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071285	cellular response to lithium ion	PMID:15673614^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050873	brown fat cell differentiation	PMID:18492766^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050872	white fat cell differentiation	PMID:15130516^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177068	P	occurs_in:(EMAPA:16039)\|occurs_in:(EMAPA:35926)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:21795542^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:16467360^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177133 MGI:MGI:2445716	P	occurs_in:(EMAPA:32860) results_in_maturation_of:(CL:0000082)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045945	positive regulation of transcription by RNA polymerase III	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18632661^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7959007^[22]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17213233^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:15175325^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045600	positive regulation of fat cell differentiation	PMID:10937998^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	PMID:12502791^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	PMID:12037571^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:18632661^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:12821655^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:17021047^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177068	P		Seeded From UniProt	complete
part_of	GO:0036488	CHOP-C/EBP complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	C		Seeded From UniProt	complete
part_of	GO:0035189	Rb-E2F complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:16467360^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177133 MGI:MGI:2445716	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030225	macrophage differentiation	PMID:15073037^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177135	P	results_in_acquisition_of_features_of:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15073037^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008203	cholesterol metabolic process	PMID:18974039^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3848341	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:25446530^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:11940593^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177053	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006360	transcription by RNA polymerase I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:18632661^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:10075730^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006351	transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12861022^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21669876^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18824566^[37]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17528) part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15519652^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16042) part_of:(CL:0000223)\|part_of:(EMAPA:16847) part_of:(CL:0000182)\|part_of:(EMAPA:16846) part_of:(CL:0000182)\|part_of:(EMAPA:16846) part_of:(CL:0000182)\|part_of:(EMAPA:16846) part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15073037^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11940593^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17213233^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:17213233^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16912278^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15073037^[30]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12821655^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10510303^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001892	embryonic placenta development	PMID:15509779^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88373	P	results_in_development_of:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:17021047^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177068	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22780989^[42]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
enables	GO:0001013	RNA polymerase I regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:10859308^[43]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:32874) has_regulation_target:(MGI:MGI:88052)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2326	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10859308^[43]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32874) has_regulation_target:(MGI:MGI:88052)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000050	urea cycle	PMID:17213233^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	C		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	P		Seeded From UniProt	complete
involved_in	GO:0045945	positive regulation of transcription by RNA polymerase III	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	C		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	F		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49715 ensembl:ENSP00000427514	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49715-4	C		Seeded From UniProt	complete
enables	GO:0001013	RNA polymerase I regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49715-4	F		Seeded From UniProt	complete
involved_in	GO:0006360	transcription by RNA polymerase I	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49715-4	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-442497	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lee, B et al. (2014) C/EBPα regulates macrophage activation and systemic metabolism. Am. J. Physiol. Endocrinol. Metab. 306 E1144-54 PubMed GONUTS page
↑ ^2.0 ^2.1 Ponomarev, ED et al. (2011) MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat. Med. 17 64-70 PubMed GONUTS page
↑ Samuelsson, L et al. (1991) The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J. 10 3787-93 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Flodby, P et al. (1996) Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J. Biol. Chem. 271 24753-60 PubMed GONUTS page
↑ Zhang, P et al. (2004) Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 21 853-63 PubMed GONUTS page
↑ Müller, C et al. (2004) The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. J. Biol. Chem. 279 7353-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Porse, BT et al. (2001) E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 107 247-58 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Pedersen, TA et al. (2007) Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J. 26 1081-93 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wang, GL et al. (2004) Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev. 18 912-25 PubMed GONUTS page
↑ ^10.0 ^10.1 Qiao, L & Shao, J (2006) SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J. Biol. Chem. 281 39915-24 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Verbeek, W et al. (1999) C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. Blood 93 3327-37 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Numata, A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J. Biol. Chem. 280 12621-9 PubMed GONUTS page
↑ Antonson, P & Xanthopoulos, KG (1995) Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha). Biochem. Biophys. Res. Commun. 215 106-13 PubMed GONUTS page
↑ Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page
↑ Stephens, JM & Pekala, PH (1992) Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. J. Biol. Chem. 267 13580-4 PubMed GONUTS page
↑ Vertino, AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol. Biol. Cell 16 2039-48 PubMed GONUTS page
↑ Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page
↑ Asaki, T et al. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol. Cell. Endocrinol. 218 119-28 PubMed GONUTS page
↑ Lu, CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J. Neurosci. 31 10903-18 PubMed GONUTS page
↑ ^20.0 ^20.1 Martis, PC et al. (2006) C/EBPalpha is required for lung maturation at birth. Development 133 1155-64 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Tomita, T et al. (2008) CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J. Biol. Chem. 283 25617-27 PubMed GONUTS page
↑ Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Chiang, MC et al. (2007) Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Hum. Mol. Genet. 16 483-98 PubMed GONUTS page
↑ Ichida, F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J. Biol. Chem. 279 34015-22 PubMed GONUTS page
↑ Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page
↑ Tang, QQ et al. (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 100 44-9 PubMed GONUTS page
↑ Ge, K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417 563-7 PubMed GONUTS page
↑ ^28.0 ^28.1 Piwien Pilipuk, G et al. (2003) Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J. Biol. Chem. 278 35668-77 PubMed GONUTS page
↑ ^29.0 ^29.1 Yamasaki, H et al. (2006) Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133 4233-43 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 Heath, V et al. (2004) C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood 104 1639-47 PubMed GONUTS page
↑ Juan, T et al. (2009) Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J. Lipid Res. 50 534-45 PubMed GONUTS page
↑ Falix, FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev. Biol. 396 201-13 PubMed GONUTS page
↑ ^33.0 ^33.1 Carmona, MC et al. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 277 21489-98 PubMed GONUTS page
↑ Fazio, S et al. (1999) Recycling of apolipoprotein E in mouse liver. J. Biol. Chem. 274 8247-53 PubMed GONUTS page
↑ Kennell, JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol. Cell. Biol. 23 5366-75 PubMed GONUTS page
↑ Fei, Z et al. (2011) Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J. Biol. Chem. 286 27761-8 PubMed GONUTS page
↑ Wang, X et al. (2008) AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J. Cell Biol. 183 37-48 PubMed GONUTS page
↑ Shiojiri, N et al. (2004) Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development. J. Hepatol. 41 790-8 PubMed GONUTS page
↑ Kyrmizi, I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20 2293-305 PubMed GONUTS page
↑ Vasseur, S et al. (1999) Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem. J. 343 Pt 2 377-83 PubMed GONUTS page
↑ Bégay, V et al. (2004) Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol. Cell. Biol. 24 9744-51 PubMed GONUTS page
↑ Faure, AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22 2163-75 PubMed GONUTS page
↑ ^43.0 ^43.1 Antes, TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. J. Biol. Chem. 275 26637-48 PubMed GONUTS page

[PMID:24691027-1] Lee, B et al. (2014) C/EBPα regulates macrophage activation and systemic metabolism. Am. J. Physiol. Endocrinol. Metab. 306 E1144-54 PubMed GONUTS page

[PMID:21131957-2] 2.0 ^2.1 Ponomarev, ED et al. (2011) MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat. Med. 17 64-70 PubMed GONUTS page

[PMID:1935900-3] Samuelsson, L et al. (1991) The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J. 10 3787-93 PubMed GONUTS page

[PMID:8798745-4] 4.0 ^4.1 ^4.2 Flodby, P et al. (1996) Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J. Biol. Chem. 271 24753-60 PubMed GONUTS page

[PMID:15589173-5] Zhang, P et al. (2004) Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 21 853-63 PubMed GONUTS page

[PMID:14660596-6] Müller, C et al. (2004) The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. J. Biol. Chem. 279 7353-8 PubMed GONUTS page

[PMID:11672531-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Porse, BT et al. (2001) E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 107 247-58 PubMed GONUTS page

[PMID:17290224-8] 8.0 ^8.1 ^8.2 Pedersen, TA et al. (2007) Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J. 26 1081-93 PubMed GONUTS page

[PMID:15107404-9] 9.0 ^9.1 ^9.2 Wang, GL et al. (2004) Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev. 18 912-25 PubMed GONUTS page

[PMID:17090532-10] 10.0 ^10.1 Qiao, L & Shao, J (2006) SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J. Biol. Chem. 281 39915-24 PubMed GONUTS page

[PMID:10233885-11] 11.0 ^11.1 ^11.2 Verbeek, W et al. (1999) C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. Blood 93 3327-37 PubMed GONUTS page

[PMID:15664994-12] 12.0 ^12.1 ^12.2 ^12.3 Numata, A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J. Biol. Chem. 280 12621-9 PubMed GONUTS page

[PMID:7575576-13] Antonson, P & Xanthopoulos, KG (1995) Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha). Biochem. Biophys. Res. Commun. 215 106-13 PubMed GONUTS page

[PMID:12055200-14] Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page

[PMID:1618860-15] Stephens, JM & Pekala, PH (1992) Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. J. Biol. Chem. 267 13580-4 PubMed GONUTS page

[PMID:15673614-16] Vertino, AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol. Biol. Cell 16 2039-48 PubMed GONUTS page

[PMID:18492766-17] Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page

[PMID:15130516-18] Asaki, T et al. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol. Cell. Endocrinol. 218 119-28 PubMed GONUTS page

[PMID:21795542-19] Lu, CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J. Neurosci. 31 10903-18 PubMed GONUTS page

[PMID:16467360-20] 20.0 ^20.1 Martis, PC et al. (2006) C/EBPalpha is required for lung maturation at birth. Development 133 1155-64 PubMed GONUTS page

[PMID:18632661-21] 21.0 ^21.1 ^21.2 Tomita, T et al. (2008) CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J. Biol. Chem. 283 25617-27 PubMed GONUTS page

[PMID:7959007-22] Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page

[PMID:17213233-23] 23.0 ^23.1 ^23.2 ^23.3 Chiang, MC et al. (2007) Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Hum. Mol. Genet. 16 483-98 PubMed GONUTS page

[PMID:15175325-24] Ichida, F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J. Biol. Chem. 279 34015-22 PubMed GONUTS page

[PMID:10937998-25] Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page

[PMID:12502791-26] Tang, QQ et al. (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 100 44-9 PubMed GONUTS page

[PMID:12037571-27] Ge, K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417 563-7 PubMed GONUTS page

[PMID:12821655-28] 28.0 ^28.1 Piwien Pilipuk, G et al. (2003) Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J. Biol. Chem. 278 35668-77 PubMed GONUTS page

[PMID:17021047-29] 29.0 ^29.1 Yamasaki, H et al. (2006) Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133 4233-43 PubMed GONUTS page

[PMID:15073037-30] 30.0 ^30.1 ^30.2 ^30.3 Heath, V et al. (2004) C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood 104 1639-47 PubMed GONUTS page

[PMID:18974039-31] Juan, T et al. (2009) Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J. Lipid Res. 50 534-45 PubMed GONUTS page

[PMID:25446530-32] Falix, FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev. Biol. 396 201-13 PubMed GONUTS page

[PMID:11940593-33] 33.0 ^33.1 Carmona, MC et al. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 277 21489-98 PubMed GONUTS page

[PMID:10075730-34] Fazio, S et al. (1999) Recycling of apolipoprotein E in mouse liver. J. Biol. Chem. 274 8247-53 PubMed GONUTS page

[PMID:12861022-35] Kennell, JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol. Cell. Biol. 23 5366-75 PubMed GONUTS page

[PMID:21669876-36] Fei, Z et al. (2011) Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J. Biol. Chem. 286 27761-8 PubMed GONUTS page

[PMID:18824566-37] Wang, X et al. (2008) AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J. Cell Biol. 183 37-48 PubMed GONUTS page

[PMID:15519652-38] Shiojiri, N et al. (2004) Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development. J. Hepatol. 41 790-8 PubMed GONUTS page

[PMID:16912278-39] Kyrmizi, I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20 2293-305 PubMed GONUTS page

[PMID:10510303-40] Vasseur, S et al. (1999) Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem. J. 343 Pt 2 377-83 PubMed GONUTS page

[PMID:15509779-41] Bégay, V et al. (2004) Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol. Cell. Biol. 24 9744-51 PubMed GONUTS page

[PMID:22780989-42] Faure, AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22 2163-75 PubMed GONUTS page

[PMID:10859308-43] 43.0 ^43.1 Antes, TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. J. Biol. Chem. 275 26637-48 PubMed GONUTS page

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