MOUSE:JUND

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Jund (synonyms: Jun-d, Jund1)
Protein Name(s)	Transcription factor jun-D
External Links
UniProt	P15066
EMBL	J04509 X15358 J05205 BC010572
CCDS	CCDS40375.1
PIR	A32158
RefSeq	NP_034722.1
UniGene	Mm.419851
ProteinModelPortal	P15066
SMR	P15066
BioGrid	200873
IntAct	P15066
MINT	MINT-4099238
STRING	10090.ENSMUSP00000092901
PhosphoSite	P15066
MaxQB	P15066
PaxDb	P15066
PRIDE	P15066
Ensembl	ENSMUST00000095267
GeneID	16478
KEGG	mmu:16478
UCSC	uc009mbe.2
CTD	3727
MGI	MGI:96648
eggNOG	NOG283376
GeneTree	ENSGT00390000009929
HOGENOM	HOG000006648
HOVERGEN	HBG001722
InParanoid	P15066
KO	K04449
OMA	APVYANL
OrthoDB	EOG75MVXV
PhylomeDB	P15066
TreeFam	TF323952
ChiTaRS	Jund
NextBio	289771
PRO	PR:P15066
Proteomes	UP000000589
Bgee	P15066
CleanEx	MM_JUND
Genevestigator	P15066
GO	GO:0005634 GO:0043234 GO:0003677 GO:0003690 GO:0043565 GO:0003700 GO:0044212 GO:0007568 GO:0071277 GO:0007623 GO:0002076 GO:0045669 GO:0045944 GO:0009416 GO:0032496 GO:0009612 GO:0014070 GO:0043434 GO:0006366
Gene3D	1.10.880.10
InterPro	IPR004827 IPR005643 IPR029823 IPR002112 IPR008917
PANTHER	PTHR11462:SF7
Pfam	PF00170 PF03957
PRINTS	PR00043
SMART	SM00338
SUPFAM	SSF47454
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:2504580^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10523647^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35639	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10523647^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P35639	P	has_regulation_target:(UniProtKB:P15066)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10523647^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:2504580^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:2504580^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:2504580^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0000978,GO:0045944	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:10837920^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96646 MGI:MGI:96647 PANTHER:PTN000894785	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 MGI:MGI:96646 MGI:MGI:96647 MGI:MGI:96648 PANTHER:PTN000894784 RGD:2943 UniProtKB:A0A1D8PIL5 UniProtKB:P05412 UniProtKB:P17275 UniProtKB:P17535	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96647 PANTHER:PTN000894785	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96646 PANTHER:PTN000894785 RGD:2943 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2944	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2945	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 RGD:2943	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943 RGD:2944 RGD:2945	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 RGD:2943	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96648 PANTHER:PTN000894785 RGD:2943 UniProtKB:P05412 WB:WBGene00012005	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 MGI:MGI:96646 PANTHER:PTN000894784 ZFIN:ZDB-GENE-030131-7859	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 UniProtKB:P05412 UniProtKB:P17275	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894785 UniProtKB:P05412	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 PANTHER:PTN000894784	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96647 MGI:MGI:96648 PANTHER:PTN000894784	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 RGD:2943	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 SGD:S000000735	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071277	cellular response to calcium ion	PMID:19303854^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19303854^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96646	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17535	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:15563473^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17535	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	F		Seeded From UniProt	complete
part_of	GO:0035976	transcription factor AP-1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17535	C		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17535	F		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17535	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2945	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12220541^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:15563473^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17535 ensembl:ENSP00000252818	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17535 ensembl:ENSP00000252818	F		Seeded From UniProt	complete
part_of	GO:0035976	transcription factor AP-1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17535 ensembl:ENSP00000252818	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17535 ensembl:ENSP00000252818	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17535 ensembl:ENSP00000252818	C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	F		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	C		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52909 ensembl:ENSRNOP00000026470	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002112 InterPro:IPR008917 InterPro:IPR029823	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002112 InterPro:IPR004827 InterPro:IPR029823	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029823	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002112 InterPro:IPR004827 InterPro:IPR008917	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029823	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hirai, SI et al. (1989) Characterization of junD: a new member of the jun proto-oncogene family. EMBO J. 8 1433-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ubeda, M et al. (1999) CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol. Cell. Biol. 19 7589-99 PubMed GONUTS page
↑ Williams, JM et al. (2000) Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Brain Res. Mol. Brain Res. 77 258-66 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Ezhkova, E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136 1122-35 PubMed GONUTS page
↑ ^6.0 ^6.1 Naito, J et al. (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J. Biol. Chem. 280 4785-91 PubMed GONUTS page
↑ Gong, P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch. Biochem. Biophys. 405 265-74 PubMed GONUTS page

[PMID:2504580-1] 1.0 ^1.1 ^1.2 ^1.3 Hirai, SI et al. (1989) Characterization of junD: a new member of the jun proto-oncogene family. EMBO J. 8 1433-9 PubMed GONUTS page

[PMID:10523647-2] 2.0 ^2.1 ^2.2 Ubeda, M et al. (1999) CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol. Cell. Biol. 19 7589-99 PubMed GONUTS page

[PMID:10837920-3] Williams, JM et al. (2000) Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Brain Res. Mol. Brain Res. 77 258-66 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19303854-5] 5.0 ^5.1 Ezhkova, E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136 1122-35 PubMed GONUTS page

[PMID:15563473-6] 6.0 ^6.1 Naito, J et al. (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J. Biol. Chem. 280 4785-91 PubMed GONUTS page

[PMID:12220541-7] Gong, P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch. Biochem. Biophys. 405 265-74 PubMed GONUTS page

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MOUSE:JUND

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