MOUSE:PLAK

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Jup
Protein Name(s)	Junction plakoglobin Desmoplakin III Desmoplakin-3
External Links
UniProt	Q02257
EMBL	AK170934 BC040757 BC094461 M90365
CCDS	CCDS25420.1
PIR	S35092
RefSeq	NP_034723.1 XP_006532378.1 XP_006532379.1
UniGene	Mm.299774
ProteinModelPortal	Q02257
SMR	Q02257
BioGrid	200874
IntAct	Q02257
MINT	MINT-4115765
PhosphoSite	Q02257
MaxQB	Q02257
PaxDb	Q02257
PRIDE	Q02257
Ensembl	ENSMUST00000001592 ENSMUST00000107403
GeneID	16480
KEGG	mmu:16480
UCSC	uc007lkz.2
CTD	3728
MGI	MGI:96650
eggNOG	NOG297695
GeneTree	ENSGT00730000110821
HOGENOM	HOG000230958
HOVERGEN	HBG000919
InParanoid	Q02257
KO	K10056
OMA	MNLIEQP
OrthoDB	EOG7X9G6B
PhylomeDB	Q02257
TreeFam	TF317997
Reactome	REACT_230395 REACT_261840
ChiTaRS	Jup
NextBio	289775
PRO	PR:Q02257
Proteomes	UP000000589
Bgee	Q02257
CleanEx	MM_JUP
Genevestigator	Q02257
GO	GO:0015629 GO:0016327 GO:0016323 GO:0030877 GO:0016342 GO:0005913 GO:0005911 GO:0009898 GO:0005829 GO:0030057 GO:0070062 GO:0005916 GO:0071665 GO:0005882 GO:0016328 GO:0016020 GO:0032993 GO:0030018 GO:0005915 GO:0045294 GO:0045296 GO:0019901 GO:0005198 GO:0003713 GO:0003181 GO:0086069 GO:0007155 GO:0016477 GO:0000902 GO:0071681 GO:0007016 GO:0002159 GO:0050982 GO:0007398 GO:0090002 GO:0007369 GO:0016331 GO:0003136 GO:0003308 GO:0007399 GO:0048599 GO:0042307 GO:0051091 GO:0045944 GO:0051291 GO:0042127 GO:0086091 GO:0016337 GO:0043588 GO:0086005
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000225 IPR013284
Pfam	PF00514
PRINTS	PR01869
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030057	desmosome	PMID:21880664^[1]	ECO:0000315			C		Figure 5	complete CACAO 6762
part_of	GO:0030057	desmosome	PMID:21880664^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	PMID:16917092^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979 ZFIN:ZDB-GENE-980526-362	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 RGD:620412 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098911	regulation of ventricular cardiac muscle cell action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	PMID:8954745^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0086091	regulation of heart rate by cardiac conduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
part_of	GO:0071665	gamma-catenin-TCF7L2 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050982	detection of mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:14579029^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26231	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:8954745^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857539	P	results_in_development_of:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	PMID:18496566^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857539	C	part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0030057	desmosome	PMID:9864371^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:25765)	Seeded From UniProt	complete
part_of	GO:0030057	desmosome	PMID:15775979^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0030057	desmosome	PMID:14673151^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	PMID:10662781^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16069)\|part_of:(EMAPA:16058)	Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:8821035^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17701) part_of:(CL:0000188)\|part_of:(EMAPA:16105) part_of:(CL:0000746)	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:8853988^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
part_of	GO:0016327	apicolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
colocalizes_with	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:12847106^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:8582267^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16046)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:15775979^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:21296051^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:18816447^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17756) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:12847106^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12847106^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620412	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002159	desmosome assembly	PMID:9847250^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857539	P	occurs_in:(EMAPA:16247)\|occurs_in:(EMAPA:17524)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002159	desmosome assembly	PMID:8954745^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002159	desmosome assembly	PMID:18496566^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857539	P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002159	desmosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14923	P		Seeded From UniProt	complete
involved_in	GO:0098911	regulation of ventricular cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
part_of	GO:0071665	gamma-catenin-TCF7L2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0050982	detection of mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	F		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	F		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	F		Seeded From UniProt	complete
involved_in	GO:0002159	desmosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14923 ensembl:ENSP00000377508	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	P		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0016327	apicolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	F		Seeded From UniProt	complete
involved_in	GO:0002159	desmosome assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	P		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284 InterPro:IPR030461	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	C		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284 InterPro:IPR030461	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0092	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Li, D et al. (2011) Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum. Mol. Genet. 20 4582-96 PubMed GONUTS page
↑ Yang, Z et al. (2006) Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ. Res. 99 646-55 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Bierkamp, C et al. (1996) Embryonic heart and skin defects in mice lacking plakoglobin. Dev. Biol. 180 780-5 PubMed GONUTS page
↑ Gual, P et al. (2003) MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 46 1532-42 PubMed GONUTS page
↑ ^6.0 ^6.1 Acehan, D et al. (2008) Plakoglobin is required for effective intermediate filament anchorage to desmosomes. J. Invest. Dermatol. 128 2665-75 PubMed GONUTS page
↑ Gallicano, GI et al. (1998) Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J. Cell Biol. 143 2009-22 PubMed GONUTS page
↑ ^8.0 ^8.1 Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page
↑ Cheng, X et al. (2004) Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol. Cell. Biol. 24 154-63 PubMed GONUTS page
↑ Huelsken, J et al. (2000) Requirement for beta-catenin in anterior-posterior axis formation in mice. J. Cell Biol. 148 567-78 PubMed GONUTS page
↑ Butz, S & Larue, L (1995) Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes. Commun. 3 337-52 PubMed GONUTS page
↑ Ohsugi, M et al. (1996) Expression and cell membrane localization of catenins during mouse preimplantation development. Dev. Dyn. 206 391-402 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Hatsell, S et al. (2003) Plakoglobin is O-glycosylated close to the N-terminal destruction box. J. Biol. Chem. 278 37745-52 PubMed GONUTS page
↑ Haegel, H et al. (1995) Lack of beta-catenin affects mouse development at gastrulation. Development 121 3529-37 PubMed GONUTS page
↑ Thomas, NM et al. (2011) Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochem. Biophys. Res. Commun. 406 117-22 PubMed GONUTS page
↑ Walker, JL et al. (2008) Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev. Dyn. 237 3128-41 PubMed GONUTS page
↑ Bierkamp, C et al. (1999) Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Development 126 371-81 PubMed GONUTS page

[PMID:21880664-1] 1.0 ^1.1 Li, D et al. (2011) Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum. Mol. Genet. 20 4582-96 PubMed GONUTS page

[PMID:16917092-2] Yang, Z et al. (2006) Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ. Res. 99 646-55 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8954745-4] 4.0 ^4.1 ^4.2 Bierkamp, C et al. (1996) Embryonic heart and skin defects in mice lacking plakoglobin. Dev. Biol. 180 780-5 PubMed GONUTS page

[PMID:14579029-5] Gual, P et al. (2003) MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 46 1532-42 PubMed GONUTS page

[PMID:18496566-6] 6.0 ^6.1 Acehan, D et al. (2008) Plakoglobin is required for effective intermediate filament anchorage to desmosomes. J. Invest. Dermatol. 128 2665-75 PubMed GONUTS page

[PMID:9864371-7] Gallicano, GI et al. (1998) Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J. Cell Biol. 143 2009-22 PubMed GONUTS page

[PMID:15775979-8] 8.0 ^8.1 Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page

[PMID:14673151-9] Cheng, X et al. (2004) Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol. Cell. Biol. 24 154-63 PubMed GONUTS page

[PMID:10662781-10] Huelsken, J et al. (2000) Requirement for beta-catenin in anterior-posterior axis formation in mice. J. Cell Biol. 148 567-78 PubMed GONUTS page

[PMID:8821035-11] Butz, S & Larue, L (1995) Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes. Commun. 3 337-52 PubMed GONUTS page

[PMID:8853988-12] Ohsugi, M et al. (1996) Expression and cell membrane localization of catenins during mouse preimplantation development. Dev. Dyn. 206 391-402 PubMed GONUTS page

[PMID:12847106-13] 13.0 ^13.1 ^13.2 Hatsell, S et al. (2003) Plakoglobin is O-glycosylated close to the N-terminal destruction box. J. Biol. Chem. 278 37745-52 PubMed GONUTS page

[PMID:8582267-14] Haegel, H et al. (1995) Lack of beta-catenin affects mouse development at gastrulation. Development 121 3529-37 PubMed GONUTS page

[PMID:21296051-15] Thomas, NM et al. (2011) Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochem. Biophys. Res. Commun. 406 117-22 PubMed GONUTS page

[PMID:18816447-16] Walker, JL et al. (2008) Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev. Dyn. 237 3128-41 PubMed GONUTS page

[PMID:9847250-17] Bierkamp, C et al. (1999) Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Development 126 371-81 PubMed GONUTS page

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