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HUMAN:MKL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MKL1 (synonyms: KIAA1438, MAL)
Protein Name(s) MKL/myocardin-like protein 1

Megakaryoblastic leukemia 1 protein Megakaryocytic acute leukemia protein Myocardin-related transcription factor A MRTF-A

External Links
UniProt Q969V6
EMBL AJ297257
AF364035
CR456522
AJ297258
AF368061
AJ303089
AJ303090
AB037859
AL022238
AL713710
CCDS CCDS14003.1
RefSeq NP_001269589.1
NP_001269590.1
NP_065882.1
XP_005261751.1
UniGene Hs.654688
PDB 2KVU
2KW9
PDBsum 2KVU
2KW9
ProteinModelPortal Q969V6
SMR Q969V6
BioGrid 121642
IntAct Q969V6
MINT MINT-4713067
STRING 9606.ENSP00000347847
DrugBank DB08080
iPTMnet Q969V6
PhosphoSitePlus Q969V6
BioMuta MKL1
DMDM 32363202
EPD Q969V6
MaxQB Q969V6
PaxDb Q969V6
PeptideAtlas Q969V6
PRIDE Q969V6
DNASU 57591
Ensembl ENST00000355630
ENST00000407029
GeneID 57591
KEGG hsa:57591
UCSC uc003ayv.3
CTD 57591
DisGeNET 57591
EuPathDB HostDB:ENSG00000196588.14
GeneCards MKL1
HGNC HGNC:14334
HPA HPA030782
MalaCards MKL1
MIM 606078
neXtProt NX_Q969V6
OpenTargets ENSG00000196588
Orphanet 402023
PharmGKB PA30827
eggNOG ENOG410IFJX
ENOG41101AM
GeneTree ENSGT00530000063195
HOGENOM HOG000038001
HOVERGEN HBG036493
InParanoid Q969V6
PhylomeDB Q969V6
TreeFam TF326024
Reactome R-HSA-5663220
SIGNOR Q969V6
ChiTaRS MKL1
EvolutionaryTrace Q969V6
GeneWiki MKL1
GenomeRNAi 57591
PRO PR:Q969V6
Proteomes UP000005640
Bgee ENSG00000196588
CleanEx HS_MAL
HS_MKL1
ExpressionAtlas Q969V6
Genevisible Q969V6
GO GO:0005737
GO:0005829
GO:0005654
GO:0005634
GO:0003779
GO:0003785
GO:0043522
GO:0001105
GO:0003713
GO:0045944
GO:0010735
GO:0051145
Gene3D 1.10.720.30
InterPro IPR029992
IPR004018
IPR003034
IPR036361
PANTHER PTHR22793:SF6
Pfam PF02755
PF02037
SMART SM00707
SM00513
SUPFAM SSF68906
PROSITE PS51073
PS50800

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4J6

P

Seeded From UniProt

complete

involved_in

GO:0051145

smooth muscle cell differentiation

PMID:14970199[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:14970199[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043522

leucine zipper domain binding

PMID:14970199[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8IZQ8

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14970199[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:14970199[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010735

positive regulation of transcription via serum response element binding

PMID:24440334[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24440334[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003785

actin monomer binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4J6

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:24440334[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K4J6

F

Seeded From UniProt

complete

involved_in

GO:0051145

smooth muscle cell differentiation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2137495
MGI:MGI:3050795
PANTHER:PTN000513566
RGD:631347
UniProtKB:Q8IZQ8
UniProtKB:Q969V6

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0044319

wound healing, spreading of cells

PMID:29391067[4]

ECO:0000314

P

Fig 2(b) and (c) shows that MKL-1 promoted more cell migration compared to a standard in a wound healing assay in HeLa cells.

Organism: Human

complete
CACAO 13060

enables

GO:0003713

transcription coactivator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029992

F

Seeded From UniProt

complete

enables

GO:0003785

actin monomer binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029992

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029992

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029992

C

Seeded From UniProt

complete

involved_in

GO:0010735

positive regulation of transcription via serum response element binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029992

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666001
Reactome:R-HSA-5665999
Reactome:R-HSA-5665982

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5666046
Reactome:R-HSA-5666008
Reactome:R-HSA-5665999
Reactome:R-HSA-5665998
Reactome:R-HSA-3900070

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Du, KL et al. (2004) Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J. Biol. Chem. 279 17578-86 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Lundquist, MR et al. (2014) Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Cell 156 563-76 PubMed GONUTS page
  3. ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Zheng, P et al. (2018) LncRNA HOTAIR promotes cell migration and invasion by regulating MKL1 via inhibition miR206 expression in HeLa cells. Cell Commun. Signal 16 5 PubMed GONUTS page
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