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PMID:29391067
| Citation |
Zheng, P, Yin, Z, Wu, Y, Xu, Y, Luo, Y and Zhang, TC (2018) LncRNA HOTAIR promotes cell migration and invasion by regulating MKL1 via inhibition miR206 expression in HeLa cells. Cell Commun. Signal 16:5 |
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| Abstract |
Long non-coding RNAs (lncRNAs) have emerged as a new and crucial layer of gene regulation in recent years and regulate various biological processes such as carcinogenesis and metastasis. LncRNA HOTAIR, an oncogenic lncRNA, is involved in human tumorigenesis and dysregulated in cervical cancer. Megakaryoblastic leukemia 1 (MKL1), as a transcription coactivity factor, involved in cancer metastasis and cell differentiation. However, the precise mechanism of biological roles of HOTAIR and MKL1 in cancer cells remain unclear. |
| Links |
PubMed Online version:10.1186/s12964-018-0216-3 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0044319: wound healing, spreading of cells |
ECO:0000314: |
P |
Fig 2(b) and (c) shows that MKL-1 promoted more cell migration compared to a standard in a wound healing assay in HeLa cells. Organism: Human |
complete | ||||
Notes
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