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User:Aataei

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CACAO Spring 2014

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableDROME:EGFR2014-02-02 00:23:29 CSTGO:0004872 receptor activity (F)PMID:22574233ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that the EGFR ligand activates the RAS-RAF-MEK and P13K-AKT-mTOR pathways that leads to cell survival and cancer cell proliferation.

challenge
unacceptableDROME:EGFR2014-02-02 01:11:22 CSTGO:0004872 receptor activity (F)PMID:22574233ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that the EGFR ligand activates the RAS-RAF-MEK and P13K-AKT-mTOR pathways that ultimately leads to cancer cell survival and proliferation.

challenge
unacceptableHUMAN:SRP682014-02-02 01:13:31 CSTPMID:24455187ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows apoptosis is induced by an excess of SRP proteins and proteotoxic stress

challenge
unacceptableSCHJY:B6K6N22014-02-02 01:14:57 CSTPMID:24466111ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows that cells transfected with control siRNA had more adhesion than TAK1 siRNA in both serum-starved cells and FGF1 treated cells.

challenge

acceptable:0
unacceptable:4
requires_changes:0
flagged:0

Annotations challenged by Aataei

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
unacceptableTatkinson,
Team Thndrcats Ho!
HUMAN:FLOT1GO:0071806 - protein transmembrane transport (P)PMID:24465508ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 3
unacceptableKgoldthorn,
Team Takin This Outside
ECO57:TUSGO:0003677 - DNA binding (F)PMID:11206551ECO:0000317 genomic context evidence used in manual assertionchallengeC: 2
unacceptableGandii2,
Team Protein Titans
GIAIA:E1F6D1GO:0060627 - regulation of vesicle-mediated transport (P)PMID:20532229ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 6
unacceptableWtrimble,
Team Pnut Butter Squares
MOUSE:MERTKGO:0002834 - regulation of response to tumor cell (P)PMID:23867499ECO:0000316 genetic interaction evidence used in manual assertionchallengeC: 3
unacceptableSprem,
Team On a Boat
HUMAN:RYR1GO:0006936 - muscle contraction (P)PMID:2298749ECO:0000255 match to sequence model evidence used in manual assertionchallengeC: 4
unacceptableSprem,
Team On a Boat
HUMAN:HXK1GO:0004396 - hexokinase activity (F)PMID:9531504ECO:0000255 match to sequence model evidence used in manual assertionchallengeC: 3
unacceptableAsigurdsson,
Team On a Boat
RAT:ASIC2GO:0005261 - cation channel activity (F)PMID:8631835ECO:0000266 sequence orthology evidence used in manual assertionchallengeC: 3
unacceptableAsigurdsson,
Team On a Boat
MOUSE:BMP2GO:0035630 - bone mineralization involved in bone maturation (P)PMID:15039429ECO:0000316 genetic interaction evidence used in manual assertionchallengeC: 3
unacceptableKdiawara,
Team Lobster Soul
9HIV1:Q2ME96GO:2000353 - positive regulation of endothelial cell apoptotic process (P)PMID:24318111ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 2
unacceptableCsobelman,
Team Lobster Soul
MOUSE:P53GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (P)PMID:12952892ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 3
unacceptableRelledge,
Team Blot Blot Wstrn Baby
MOUSE:TNR16GO:0045773 - positive regulation of axon extension (P)PMID:3815101ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 3
updatedbyinstructorKfree,
Team Bfast Taco
MOUSE:ACHB4GO:0051971 - positive regulation of transmission of nerve impulse (P)PMID:12606764ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 5

fixed by Kfree
unacceptableRthompson,
Team Bfast Taco
HUMAN:PEPA5GO:0006508 - proteolysis (P)other:PMC1712889ECO:0000314 direct assay evidence used in manual assertionchallengeC: 3
unacceptableRthompson,
Team Bfast Taco
HUMAN:PROCGO:0030195 - negative regulation of blood coagulation (P)PMID:9529319ECO:0000304 author statement supported by traceable reference used in manual assertionchallengeC: 2
unacceptableKfree,
Team Bfast Taco
MOUSE:P85AGO:0032762 - mast cell cytokine production (P)PMID:24454942ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 1
updatedbyinstructorAross,
Team BAMF
DROME:ABLGO:0010592 - positive regulation of lamellipodium assembly (P)PMID:24466097ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 4
updatedbyinstructorAross,
Team BAMF
DROME:ABLGO:0010977 - negative regulation of neuron projection development (P)PMID:24466097ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 4
unacceptableAstephens2,
Team Bacon Pancakes
HUMAN:FADDPMID:14702039ECO:0000314 direct assay evidence used in manual assertionchallengeC: 2
unacceptableAstephens2,
Team Bacon Pancakes
HUMAN:SHBGGO:0007285 - primary spermatocyte growth (P)PMID:3569533ECO:0000255 match to sequence model evidence used in manual assertionchallengeC: 2
unacceptableAstephens2,
Team Bacon Pancakes
HUMAN:SHBGGO:0007285 - primary spermatocyte growth (P)PMID:2956126ECO:0000255 match to sequence model evidence used in manual assertionchallengeC: 3

0 annotations fixed by Aataei

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