HUMAN:HXK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HK1
Protein Name(s)	Hexokinase-1 Brain form hexokinase Hexokinase type I HK I
External Links
UniProt	P19367
EMBL	M75126 AF016365 AF016349 AF016351 AF016352 AF016353 AF016354 AF016355 AF016356 AF016357 AF016358 AF016359 AF016360 AF016361 AF016362 AF016363 AF016364 AF016365 AF016349 AF016351 AF016352 AF016353 AF016354 AF016355 AF016356 AF016357 AF016358 AF016359 AF016360 AF016361 AF016362 AF016363 AF016364 AF016365 AF163910 AF163911 AF016351 AF016352 AF016353 AF016354 AF016355 AF016356 AF016357 AF016358 AF016359 AF016360 AF016361 AF016362 AF016363 AF016364 AF016365 AF163912 AF016351 AF016352 AF016353 AF016354 AF016355 AF016356 AF016357 AF016358 AF016359 AF016360 AF016361 AF016362 AF016363 AF016364 AL596223 AC016821 AL672126 BC008730 AF073786 AF029306 X66957
CCDS	CCDS7289.1 CCDS7290.1 CCDS7291.1 CCDS7292.1
PIR	A31869
RefSeq	NP_000179.2 NP_277031.1 NP_277032.1 NP_277033.1 NP_277035.2 XP_005269793.1
UniGene	Hs.370365
PDB	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
PDBsum	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
ProteinModelPortal	P19367
SMR	P19367
BioGrid	109345
IntAct	P19367
MINT	MINT-1422832
STRING	9606.ENSP00000348697
BindingDB	P19367
ChEMBL	CHEMBL2688
PhosphoSite	P19367
DMDM	116242516
MaxQB	P19367
PaxDb	P19367
PRIDE	P19367
DNASU	3098
Ensembl	ENST00000298649 ENST00000359426 ENST00000360289 ENST00000448642
GeneID	3098
KEGG	hsa:3098
UCSC	uc001jpg.4 uc001jph.4 uc001jpk.4 uc001jpl.4
CTD	3098
GeneCards	GC10P071031
HGNC	HGNC:4922
HPA	CAB010052 HPA007043 HPA007044 HPA011956
MIM	142600 235700 605285
neXtProt	NX_P19367
Orphanet	99953 90031
PharmGKB	PA29300
eggNOG	COG5026
GeneTree	ENSGT00390000017159
HOVERGEN	HBG005020
InParanoid	P19367
KO	K00844
OrthoDB	EOG7S21X5
PhylomeDB	P19367
TreeFam	TF314238
BioCyc	MetaCyc:HS08136-MONOMER
Reactome	REACT_212
SABIO-RK	P19367
UniPathway	UPA00242
ChiTaRS	HK1
EvolutionaryTrace	P19367
GenomeRNAi	3098
NextBio	12293
PRO	PR:P19367
Proteomes	UP000005640
Bgee	P19367
CleanEx	HS_HK1
ExpressionAtlas	P19367
Genevestigator	P19367
GO	GO:0005829 GO:0005741 GO:0005739 GO:0005524 GO:0008865 GO:0004340 GO:0004396 GO:0019158 GO:0005975 GO:0046835 GO:0001678 GO:0051156 GO:0015758 GO:0006096 GO:0019318 GO:0008645 GO:0044281 GO:0055085
InterPro	IPR001312 IPR022673 IPR019807 IPR022672
PANTHER	PTHR19443
Pfam	PF00349 PF03727
PRINTS	PR00475
PROSITE	PS00378

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004396	hexokinase activity	PMID:9531504^[1]	ECO:0000255		PMID:9531504^[1]	F		Figure 2 shows the sequences of the 5'flanking region of exon 1, exon 1 and 5' splice junction of intron .	complete CACAO 9454
enables	GO:0042834	peptidoglycan binding	PMID:27374331^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	PMID:27374331^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:27374331^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072656	maintenance of protein location in mitochondrion	PMID:23962723^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0072655	establishment of protein localization to mitochondrion	PMID:23962723^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:20833797^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001134)	Seeded From UniProt	complete
enables	GO:0019158	mannokinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c	F		Seeded From UniProt	complete
enables	GO:0008865	fructokinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P93834 UniProtKB:Q4WHC3	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000000545 SGD:S000001949 SGD:S000003222	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000003222 UniProtKB:C6KT76 UniProtKB:P35557	C		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c RGD:2670 RGD:2796 SGD:S000000545 TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P35557 UniProtKB:P93834 UniProtKB:Q4WCS2 UniProtKB:Q4WHC3 UniProtKB:Q5W676 UniProtKB:Q8LQ68	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455350 RGD:2670	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:29568061^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19367	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:28054552^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19367	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004340	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	C		Seeded From UniProt	complete
enables	GO:0042834	peptidoglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	C		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	F		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17710 ensembl:ENSMUSP00000111946	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	P		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807 InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	F		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR022672 InterPro:IPR022673	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019807	P		Seeded From UniProt	complete
enables	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.1	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:3207429^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:3207429^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	Reactome:R-HSA-70171	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-70420	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0019318	hexose metabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00242	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ruzzo, A et al. (1998) Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region. Biochem. J. 331 ( Pt 2) 607-13 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Wolf, AJ et al. (2016) Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell 166 624-636 PubMed GONUTS page
↑ ^3.0 ^3.1 McCoy, MK et al. (2014) Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Hum. Mol. Genet. 23 145-56 PubMed GONUTS page
↑ Zhao, X et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol. Cell Proteomics 10 M110.000299 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Liu, X et al. (2018) An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nat Commun 9 1188 PubMed GONUTS page
↑ Zhang, J et al. (2017) c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis. Nat Commun 8 13732 PubMed GONUTS page
↑ ^8.0 ^8.1 Nishi, S et al. (1988) Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous. Biochem. Biophys. Res. Commun. 157 937-43 PubMed GONUTS page

[PMID:9531504-1] 1.0 ^1.1 Ruzzo, A et al. (1998) Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region. Biochem. J. 331 ( Pt 2) 607-13 PubMed GONUTS page

[PMID:27374331-2] 2.0 ^2.1 ^2.2 Wolf, AJ et al. (2016) Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell 166 624-636 PubMed GONUTS page

[PMID:23962723-3] 3.0 ^3.1 McCoy, MK et al. (2014) Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Hum. Mol. Genet. 23 145-56 PubMed GONUTS page

[PMID:20833797-4] Zhao, X et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol. Cell Proteomics 10 M110.000299 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29568061-6] Liu, X et al. (2018) An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nat Commun 9 1188 PubMed GONUTS page

[PMID:28054552-7] Zhang, J et al. (2017) c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis. Nat Commun 8 13732 PubMed GONUTS page

[PMID:3207429-8] 8.0 ^8.1 Nishi, S et al. (1988) Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous. Biochem. Biophys. Res. Commun. 157 937-43 PubMed GONUTS page

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HUMAN:HXK1

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