DROME:ABL

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Abl (synonyms: ABL-1, Dash)
Protein Name(s)	Tyrosine-protein kinase Abl D-ash Protein abelson
External Links
UniProt	P00522
EMBL	M19692 M19690 M19691 AE014296 AY058497 K01042
PIR	A28128
RefSeq	NP_001287085.1 NP_524843.2
UniGene	Dm.5397
ProteinModelPortal	P00522
SMR	P00522
BioGrid	69904
IntAct	P00522
PaxDb	P00522
EnsemblMetazoa	FBtr0075357
GeneID	45821
KEGG	dme:Dmel_CG4032
CTD	45821
FlyBase	FBgn0000017
eggNOG	COG0515
GeneTree	ENSGT00760000118938
InParanoid	P00522
KO	K06619
OrthoDB	EOG7GTT2V
BRENDA	2.7.10.2
Reactome	REACT_180258 REACT_181315 REACT_246045 REACT_256055
SignaLink	P00522
GenomeRNAi	45821
NextBio	838372
PRO	PR:P00522
Proteomes	UP000000803
Bgee	P00522
ExpressionAtlas	P00522
GO	GO:0005912 GO:0045179 GO:0030424 GO:0005938 GO:0005911 GO:0005737 GO:0005829 GO:0019897 GO:0005927 GO:0005524 GO:0004715 GO:0004713 GO:0007411 GO:0016199 GO:0007409 GO:0007417 GO:0048749 GO:0007303 GO:0007391 GO:0003382 GO:0002009 GO:0008045 GO:0045886 GO:0001764 GO:0018108 GO:0072499 GO:0003402 GO:0046827 GO:0006468 GO:0008064 GO:0008360 GO:0032880 GO:0031647 GO:0007419 GO:0007370
Gene3D	3.30.505.10
InterPro	IPR015015 IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF08919 PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00109
SMART	SM00808 SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007611	learning or memory	PMID:1321066^[1]	ECO:0000315			P		figure 2, flies with mutant latheo gene have poor memory, statistically significant.	complete CACAO 3437
	GO:0007268	synaptic transmission	PMID:10402193^[2]	ECO:0000315			P		fig 3 synaptuc transmission is elevated in lat mutants	complete CACAO 3442
	GO:0004713	protein tyrosine kinase activity	PMID:2832740^[3]	ECO:0000247		UniProtKB:P00519	F		tyrosine kinase activity inferred from sequence similarity to human abl tyrosine kinase. kinase activity observed from expression products of transformed e.coli with Drosophila abl	complete CACAO 3402
	GO:0021785	branchiomotor neuron axon guidance	PMID:10069335^[4]	ECO:0000315			P		See Figure 4C for mutant phenotype of abl expression.	complete CACAO 5080
	GO:0010592	positive regulation of lamellipodium assembly	PMID:24466097^[5]	ECO:0000315			P		Compared to WT control, Abl neurons exhibited tendency to show fewer veil-like structures and well developed, large lamellipodia (>4 µm2) occurred only at a lower frequency (Fig. 5)	complete CACAO 9390
	GO:0010977	negative regulation of neuron projection development	PMID:24466097^[5]	ECO:0000315			P		Consistent with the altered neuronal growth in the larval CNS culture [24], neurons in Abl cultures displayed... more swollen, dark nodes along neurites (Fig. 4B1).	complete CACAO 9391
involved_in	GO:0007268	chemical synaptic transmission	PMID:10402193^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:1321066^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:2832740^[3]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P00519	F		Seeded From UniProt	complete
involved_in	GO:0021785	branchiomotor neuron axon guidance	PMID:10069335^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:24466097^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	PMID:24466097^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87859 PANTHER:PTN001975310 UniProtKB:Q05397	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001975310 RGD:628758 UniProtKB:P00519 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001975310 RGD:628758	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000017 MGI:MGI:104908 MGI:MGI:1930958 MGI:MGI:95481 PANTHER:PTN001975310 UniProtKB:P00519 UniProtKB:Q05397 UniProtKB:Q14289 WB:WBGene00002213	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:25294944^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0070938	contractile ring	PMID:25294944^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:16054027^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003401	axis elongation	PMID:22340496^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:21726548^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:20498300^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:19675132^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007303	cytoplasmic transport, nurse cell to oocyte	PMID:19576200^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072499	photoreceptor cell axon guidance	PMID:19217428^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:19217428^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048749	compound eye development	PMID:19217428^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000320	P		Seeded From UniProt	complete
involved_in	GO:0007419	ventral cord development	PMID:19217428^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072499	photoreceptor cell axon guidance	PMID:19217428^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000320	P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	PMID:19217428^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:19217428^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:19217428^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007419	ventral cord development	PMID:19211897^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0033159	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:17804420^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:17804420^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:10798396^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:1295746^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005927	muscle tendon junction	PMID:1295746^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:1295746^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0019897	extrinsic component of plasma membrane	PMID:1295746^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:2175256^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:17804420^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:17804420^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17804420^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:17568577^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045179	apical cortex	PMID:17202187^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007370	ventral furrow formation	PMID:17202187^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:2175256^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:2175256^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004108	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:17202187^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:16003769^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:2406026^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0285925	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:2502313^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004108	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:2832740^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016199	axon midline choice point recognition	PMID:12973825^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:12781136^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:11756472^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003382	epithelial cell morphogenesis	PMID:11756472^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10908587^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10908587^[28]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10892742^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:10892742^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:10892742^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0005631	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:2175256^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:2175256^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:22340496^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:22340496^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(FB:FBgn0000117)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635 InterPro:IPR033221	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015015	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR015015 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR015015 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-428884 Reactome:R-DME-428887	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008064	regulation of actin polymerization or depolymerization	PMID:12231351^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12147138^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Boynton, S & Tully, T (1992) latheo, a new gene involved in associative learning and memory in Drosophila melanogaster, identified from P element mutagenesis. Genetics 131 655-72 PubMed GONUTS page
↑ ^2.0 ^2.1 Rohrbough, J et al. (1999) latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron 23 55-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Henkemeyer, MJ et al. (1988) DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol. Cell. Biol. 8 843-53 PubMed GONUTS page
↑ ^4.0 ^4.1 Wills, Z et al. (1999) Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron 22 291-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Liu, L & Wu, CF (2014) Distinct effects of Abelson kinase mutations on myocytes and neurons in dissociated Drosophila embryonic cultures: mimicking of high temperature. PLoS ONE 9 e86438 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
↑ Jékely, G et al. (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9 197-207 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Tamada, M et al. (2012) Abl regulates planar polarized junctional dynamics through β-catenin tyrosine phosphorylation. Dev. Cell 22 309-19 PubMed GONUTS page
↑ Zhu, Z & Bhat, KM (2011) The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. Dev. Biol. 357 283-94 PubMed GONUTS page
↑ Lowery, LA et al. (2010) Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Genetics 185 1311-25 PubMed GONUTS page
↑ Lin, TY et al. (2009) Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development 136 3099-107 PubMed GONUTS page
↑ Gates, J et al. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev. Biol. 333 90-107 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Xiong, W et al. (2009) Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev. Cell 16 271-9 PubMed GONUTS page
↑ Yu, HH et al. (2009) Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis. J. Neurosci. 29 1904-14 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Huang, CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J. Biol. Chem. 282 32442-52 PubMed GONUTS page
↑ Liebl, EC et al. (2000) Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron 26 107-18 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Bennett, RL & Hoffmann, FM (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116 953-66 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Henkemeyer, M et al. (1990) A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell 63 949-60 PubMed GONUTS page
↑ Dorsten, JN et al. (2007) Frazzled regulation of myosin II activity in the Drosophila embryonic CNS. Dev. Biol. 308 120-32 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Fox, DT & Peifer, M (2007) Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134 567-78 PubMed GONUTS page
↑ Li, W et al. (2005) Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Dev. Dyn. 234 512-22 PubMed GONUTS page
↑ Elkins, T et al. (1990) Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60 565-75 PubMed GONUTS page
↑ Gertler, FB et al. (1989) Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58 103-13 PubMed GONUTS page
↑ Hsouna, A et al. (2003) Abelson tyrosine kinase is required to transduce midline repulsive cues. J. Neurobiol. 57 15-30 PubMed GONUTS page
↑ Crowner, D et al. (2003) Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr. Biol. 13 967-72 PubMed GONUTS page
↑ ^27.0 ^27.1 Grevengoed, EE et al. (2001) Abelson kinase regulates epithelial morphogenesis in Drosophila. J. Cell Biol. 155 1185-98 PubMed GONUTS page
↑ ^28.0 ^28.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Bashaw, GJ et al. (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101 703-15 PubMed GONUTS page
↑ Martin, P & Wood, W (2002) Epithelial fusions in the embryo. Curr. Opin. Cell Biol. 14 569-74 PubMed GONUTS page
↑ Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[PMID:1321066-1] 1.0 ^1.1 Boynton, S & Tully, T (1992) latheo, a new gene involved in associative learning and memory in Drosophila melanogaster, identified from P element mutagenesis. Genetics 131 655-72 PubMed GONUTS page

[PMID:10402193-2] 2.0 ^2.1 Rohrbough, J et al. (1999) latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron 23 55-70 PubMed GONUTS page

[PMID:2832740-3] 3.0 ^3.1 ^3.2 Henkemeyer, MJ et al. (1988) DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol. Cell. Biol. 8 843-53 PubMed GONUTS page

[PMID:10069335-4] 4.0 ^4.1 Wills, Z et al. (1999) Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron 22 291-9 PubMed GONUTS page

[PMID:24466097-5] 5.0 ^5.1 ^5.2 ^5.3 Liu, L & Wu, CF (2014) Distinct effects of Abelson kinase mutations on myocytes and neurons in dissociated Drosophila embryonic cultures: mimicking of high temperature. PLoS ONE 9 e86438 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25294944-7] 7.0 ^7.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page

[PMID:16054027-8] Jékely, G et al. (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9 197-207 PubMed GONUTS page

[PMID:22340496-9] 9.0 ^9.1 ^9.2 Tamada, M et al. (2012) Abl regulates planar polarized junctional dynamics through β-catenin tyrosine phosphorylation. Dev. Cell 22 309-19 PubMed GONUTS page

[PMID:21726548-10] Zhu, Z & Bhat, KM (2011) The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. Dev. Biol. 357 283-94 PubMed GONUTS page

[PMID:20498300-11] Lowery, LA et al. (2010) Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Genetics 185 1311-25 PubMed GONUTS page

[PMID:19675132-12] Lin, TY et al. (2009) Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development 136 3099-107 PubMed GONUTS page

[PMID:19576200-13] Gates, J et al. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev. Biol. 333 90-107 PubMed GONUTS page

[PMID:19217428-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Xiong, W et al. (2009) Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev. Cell 16 271-9 PubMed GONUTS page

[PMID:19211897-15] Yu, HH et al. (2009) Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis. J. Neurosci. 29 1904-14 PubMed GONUTS page

[PMID:17804420-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Huang, CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J. Biol. Chem. 282 32442-52 PubMed GONUTS page

[PMID:10798396-17] Liebl, EC et al. (2000) Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron 26 107-18 PubMed GONUTS page

[PMID:1295746-18] 18.0 ^18.1 ^18.2 ^18.3 Bennett, RL & Hoffmann, FM (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116 953-66 PubMed GONUTS page

[PMID:2175256-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Henkemeyer, M et al. (1990) A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell 63 949-60 PubMed GONUTS page

[PMID:17568577-20] Dorsten, JN et al. (2007) Frazzled regulation of myosin II activity in the Drosophila embryonic CNS. Dev. Biol. 308 120-32 PubMed GONUTS page

[PMID:17202187-21] 21.0 ^21.1 ^21.2 Fox, DT & Peifer, M (2007) Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134 567-78 PubMed GONUTS page

[PMID:16003769-22] Li, W et al. (2005) Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Dev. Dyn. 234 512-22 PubMed GONUTS page

[PMID:2406026-23] Elkins, T et al. (1990) Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60 565-75 PubMed GONUTS page

[PMID:2502313-24] Gertler, FB et al. (1989) Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58 103-13 PubMed GONUTS page

[PMID:12973825-25] Hsouna, A et al. (2003) Abelson tyrosine kinase is required to transduce midline repulsive cues. J. Neurobiol. 57 15-30 PubMed GONUTS page

[PMID:12781136-26] Crowner, D et al. (2003) Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr. Biol. 13 967-72 PubMed GONUTS page

[PMID:11756472-27] 27.0 ^27.1 Grevengoed, EE et al. (2001) Abelson kinase regulates epithelial morphogenesis in Drosophila. J. Cell Biol. 155 1185-98 PubMed GONUTS page

[PMID:10908587-28] 28.0 ^28.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page

[PMID:10892742-29] 29.0 ^29.1 ^29.2 Bashaw, GJ et al. (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101 703-15 PubMed GONUTS page

[PMID:12231351-30] Martin, P & Wood, W (2002) Epithelial fusions in the embryo. Curr. Opin. Cell Biol. 14 569-74 PubMed GONUTS page

[PMID:12147138-31] Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

DROME:ABL

Contents

Annotations

Notes

References

a

b

c

d

e

h

i

k

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools