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PMID:10069335
| Citation |
Wills, Z, Marr, L, Zinn, K, Goodman, CS and Van Vactor, D (1999) Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron 22:291-9 |
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| Abstract |
The ability of neuronal growth cones to be guided by extracellular cues requires intimate communication between signal transduction systems and the dynamic actin-based cytoskeleton at the leading edge. Profilin, a small, actin-binding protein, has been proposed to be a regulator of the cell motility machinery at leading edge membranes. However, its requirement in the developing nervous system has been unknown. Profilin associates with members of the Enabled family of proteins, suggesting that Profilin might link Abl function to the cytoskeleton. Here, genetic analysis in Drosophila is used to demonstrate that mutations in Profilin (chickadee) and Abl (abl) display an identical growth cone arrest phenotype for axons of intersegmental nerve b (ISNb). Moreover, the phenotype of a double mutant suggests that these components function together to control axonal outgrowth. |
| Links | |
| Keywords |
Alleles; Animals; Axons/physiology; Contractile Proteins; Drosophila/embryology; Drosophila Proteins; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/physiology; Microfilament Proteins/genetics; Microfilament Proteins/physiology; Motor Neurons/physiology; Mutation/genetics; Nervous System/cytology; Nervous System/embryology; Profilins; Proto-Oncogene Proteins c-abl/genetics; Proto-Oncogene Proteins c-abl/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0048842: positive regulation of axon extension involved in axon guidance |
ECO:0000315: |
P |
Figure 1 shows the mutant and wild-type chic gene |
complete | ||||
|
involved_in |
GO:0048842: positive regulation of axon extension involved in axon guidance |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0021785: branchiomotor neuron axon guidance |
ECO:0000315: |
P |
See Figure 4C for mutant phenotype of abl expression. |
complete | ||||
|
involved_in |
GO:0021785: branchiomotor neuron axon guidance |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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