MOUSE:P85A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pik3r1
Protein Name(s)	Phosphatidylinositol 3-kinase regulatory subunit alpha PI3-kinase regulatory subunit alpha PI3K regulatory subunit alpha PtdIns-3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha PI3-kinase subunit p85-alpha PtdIns-3-kinase regulatory subunit p85-alpha
External Links
UniProt	P26450
EMBL	M60651 CH466567 BC026146
CCDS	CCDS36769.1
RefSeq	NP_001070963.1
UniGene	Mm.259333
ProteinModelPortal	P26450
SMR	P26450
BioGrid	202162
DIP	DIP-39593N
IntAct	P26450
MINT	MINT-103410
PhosphoSite	P26450
MaxQB	P26450
PaxDb	P26450
PRIDE	P26450
Ensembl	ENSMUST00000055518
GeneID	18708
KEGG	mmu:18708
UCSC	uc007rrt.2
CTD	5295
MGI	MGI:97583
eggNOG	NOG263689
GeneTree	ENSGT00390000010431
HOGENOM	HOG000008438
HOVERGEN	HBG082100
InParanoid	P26450
KO	K02649
OMA	LNGYNET
OrthoDB	EOG7BP831
TreeFam	TF102033
Reactome	REACT_188185 REACT_188194 REACT_188578 REACT_196455 REACT_196460 REACT_196588 REACT_198634 REACT_198701 REACT_198973 REACT_199123 REACT_203296 REACT_204733 REACT_205300 REACT_206286 REACT_207651 REACT_210240 REACT_210793 REACT_211860 REACT_213364 REACT_215348 REACT_220092 REACT_223974 REACT_223993 REACT_225145 REACT_225477 REACT_225836 REACT_226151 REACT_226341 REACT_230639 REACT_240139 REACT_245546 REACT_257032 REACT_257088
ChiTaRS	Pik3r1
NextBio	294779
PRO	PR:P26450
Proteomes	UP000000589
Bgee	P26450
ExpressionAtlas	P26450
Genevestigator	P26450
GO	GO:0005911 GO:0005737 GO:0005829 GO:0016020 GO:0005942 GO:0005943 GO:0016303 GO:0043125 GO:0043559 GO:0005158 GO:0043560 GO:0005159 GO:0035014 GO:0030183 GO:0034644 GO:0008625 GO:0060396 GO:0008286 GO:0048009 GO:0008630 GO:0043066 GO:0001953 GO:0045671 GO:0051531 GO:0014065 GO:0046854 GO:0036092 GO:0030335 GO:0045944 GO:0032760 GO:0006468 GO:0043551
Gene3D	1.10.555.10 3.30.505.10
InterPro	IPR001720 IPR008936 IPR000198 IPR000980 IPR011511 IPR001452
PANTHER	PTHR10155
Pfam	PF00620 PF00017 PF07653
PRINTS	PR00678 PR00401
SMART	SM00324 SM00252 SM00326
SUPFAM	SSF48350 SSF50044 SSF55550
PROSITE	PS50238 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032762	mast cell cytokine production	PMID:24454942^[1]	ECO:0000315			P		Fig. 6D shows PI3K KO mice exhibit lower expression of cytokines in mucosal cells compared to WT mice. Fig. 6C shows similar cytokine expression in KO and WT mice, suggesting that PI3K is involved in gastrointestinal mast cell cytokine production and not systemic mast cell cytokine production.	complete CACAO 9386
enables	GO:0046982	protein heterodimerization activity	PMID:20348926^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O08908	F		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:20348926^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O35426) part_of:(GO:0008286)	Seeded From UniProt	complete
enables	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	PMID:20348926^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O08908	F		Seeded From UniProt	complete
involved_in	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:20348926^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20348926^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20348926^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:20348926^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:20348926^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:20348926^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20348926^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O08908	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20348926^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35426-2	F		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:20348926^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:16043515^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35568	F		Seeded From UniProt	complete
enables	GO:0043125	ErbB-3 class receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16043515^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16043515^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16043515^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 RGD:621042	F		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020622 PANTHER:PTN000806614 UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000016388 RGD:3329 UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 MGI:MGI:1098772 MGI:MGI:97583 PANTHER:PTN000016388 RGD:3329 UniProtKB:P23727 WB:WBGene00000001	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 UniProtKB:P23727 WB:WBGene00000001	C		Seeded From UniProt	complete
part_of	GO:1990578	perinuclear endoplasmic reticulum membrane	PMID:25217619^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903076	regulation of protein localization to plasma membrane	PMID:25217619^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060396	growth hormone receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051591	response to cAMP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051492	regulation of stress fiber assembly	PMID:25217619^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149438	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051384	response to glucocorticoid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046626	regulation of insulin receptor signaling pathway	PMID:26657864^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88315	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17242187^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149414	P	regulates_o_occurs_in:(CL:0000057) has_regulation_target:(MGI:MGI:104798)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045861	negative regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045776	negative regulation of blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045671	negative regulation of osteoclast differentiation	PMID:17053831^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97306	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0043125	ErbB-3 class receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:15192701^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034644	cellular response to UV	PMID:17242187^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103296	P	occurs_in:(CL:0000057)\|occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034644	cellular response to UV	PMID:17242187^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149414	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033120	positive regulation of RNA splicing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:26657864^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	PMID:26657864^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032868	response to insulin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:17242187^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	PMID:17053831^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97306	P	regulates_o_results_in_movement_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030183	B cell differentiation	PMID:9988280^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149414	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022408	negative regulation of cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
contributes_to	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010656	negative regulation of muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010459	negative regulation of heart rate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:17242187^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:17242187^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149414	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:15039234^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97306	P	regulates_o_occurs_in:(EMAPA:32760) regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:15039234^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32760) regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007162	negative regulation of cell adhesion	PMID:25217619^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:17242187^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149414	P	occurs_in:(CL:0000057) has_direct_input:(MGI:MGI:1920431)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15192701^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:23793062^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	C		Seeded From UniProt	complete
part_of	GO:0005801	cis-Golgi network	PMID:25217619^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
enables	GO:0005168	neurotrophin TRKA receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001953	negative regulation of cell-matrix adhesion	PMID:17053831^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97306	P	regulates_o_has_participant:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3329	P		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016303	P		Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016303	P		Seeded From UniProt	complete
involved_in	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
involved_in	GO:0060396	growth hormone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
enables	GO:0043125	ErbB-3 class receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	C		Seeded From UniProt	complete
enables	GO:0005168	neurotrophin TRKA receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27986 ensembl:ENSP00000428056	F		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001720	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000198 InterPro:IPR008936	P		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001720	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9616944 Reactome:R-NUL-9603412 Reactome:R-NUL-9031077 Reactome:R-MMU-9031553 Reactome:R-MMU-9027268 Reactome:R-MMU-5218853	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:9988280^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:9988280^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yamamoto, T et al. (2014) Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS ONE 9 e85888 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Park, SW et al. (2010) The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat. Med. 16 429-37 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Luo, J et al. (2005) The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J. Cell Biol. 170 455-64 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Cariaga-Martínez, AE et al. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open 3 924-36 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lagarrigue, S et al. (2016) CDK4 is an essential insulin effector in adipocytes. J. Clin. Invest. 126 335-48 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Song, L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol. Cell. Biol. 27 2713-31 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yang, FC et al. (2006) Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J. Clin. Invest. 116 2880-91 PubMed GONUTS page
↑ ^9.0 ^9.1 Baki, L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 2586-96 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Terauchi, Y et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat. Genet. 21 230-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Hiatt, K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am. J. Pathol. 164 1471-9 PubMed GONUTS page
↑ Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page

[PMID:24454942-1] Yamamoto, T et al. (2014) Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS ONE 9 e85888 PubMed GONUTS page

[PMID:20348926-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Park, SW et al. (2010) The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat. Med. 16 429-37 PubMed GONUTS page

[PMID:16043515-3] 3.0 ^3.1 ^3.2 ^3.3 Luo, J et al. (2005) The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J. Cell Biol. 170 455-64 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25217619-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Cariaga-Martínez, AE et al. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open 3 924-36 PubMed GONUTS page

[PMID:26657864-6] 6.0 ^6.1 ^6.2 Lagarrigue, S et al. (2016) CDK4 is an essential insulin effector in adipocytes. J. Clin. Invest. 126 335-48 PubMed GONUTS page

[PMID:17242187-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Song, L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol. Cell. Biol. 27 2713-31 PubMed GONUTS page

[PMID:17053831-8] 8.0 ^8.1 ^8.2 Yang, FC et al. (2006) Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J. Clin. Invest. 116 2880-91 PubMed GONUTS page

[PMID:15192701-9] 9.0 ^9.1 Baki, L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 2586-96 PubMed GONUTS page

[PMID:9988280-10] 10.0 ^10.1 ^10.2 Terauchi, Y et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat. Genet. 21 230-5 PubMed GONUTS page

[PMID:15039234-11] 11.0 ^11.1 Hiatt, K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am. J. Pathol. 164 1471-9 PubMed GONUTS page

[PMID:23793062-12] Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page

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MOUSE:P85A

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