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MOUSE:P53

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tp53 (synonyms: P53, Trp53)
Protein Name(s) Cellular tumor antigen p53

Tumor suppressor p53

External Links
UniProt P02340
EMBL X00876
X00877
X00878
X00879
X00880
X00881
X00882
X00883
X00884
X00885
X01237
X00741
M13872
M13873
M13874
AB021961
AF151353
AB017815
AB017816
AB020317
BC005448
S77930
PIR A22739
S38824
RefSeq NP_001120705.1
NP_035770.2
XP_006533220.1
XP_006533221.1
UniGene Mm.222
PDB 1HU8
2GEQ
2IOI
2IOM
2IOO
2P52
3EXJ
3EXL
PDBsum 1HU8
2GEQ
2IOI
2IOM
2IOO
2P52
3EXJ
3EXL
ProteinModelPortal P02340
SMR P02340
BioGrid 204323
DIP DIP-369N
IntAct P02340
MINT MINT-120104
STRING 10090.ENSMUSP00000104298
ChEMBL CHEMBL4164
PhosphoSite P02340
MaxQB P02340
PRIDE P02340
Ensembl ENSMUST00000005371
GeneID 22059
KEGG mmu:22059
UCSC uc007jql.2
CTD 22059
MGI MGI:98834
eggNOG NOG80479
GeneTree ENSGT00390000015092
HOGENOM HOG000039957
HOVERGEN HBG005201
InParanoid P02340
KO K04451
OrthoDB EOG7JQBNW
Reactome REACT_188819
REACT_188970
REACT_188971
REACT_198649
REACT_209428
REACT_212633
REACT_256790
EvolutionaryTrace P02340
NextBio 301858
PRO PR:P02340
Proteomes UP000000589
Bgee P02340
CleanEx MM_TRP53
ExpressionAtlas P02340
Genevestigator P02340
GO GO:0000785
GO:0005737
GO:0005829
GO:0005783
GO:0005759
GO:0005739
GO:0005730
GO:0005634
GO:0005657
GO:0005667
GO:0005524
GO:0003682
GO:0005507
GO:0003684
GO:0003677
GO:0003690
GO:0035033
GO:0097371
GO:0002039
GO:0001077
GO:0000979
GO:0043565
GO:0003700
GO:0006915
GO:0002326
GO:0007569
GO:0006974
GO:0071479
GO:0034644
GO:0007417
GO:0021549
GO:0051276
GO:0008340
GO:0030330
GO:0006977
GO:0006978
GO:0000733
GO:0006302
GO:0009792
GO:0048568
GO:0007369
GO:0001701
GO:0072332
GO:0042771
GO:0043504
GO:0071850
GO:0031571
GO:0035264
GO:0007275
GO:0070266
GO:0043066
GO:0030308
GO:0008285
GO:0008156
GO:0048147
GO:1901525
GO:0045930
GO:0007406
GO:2000378
GO:0000122
GO:0045892
GO:0030512
GO:0051402
GO:0006289
GO:0097252
GO:0043065
GO:0010666
GO:0090343
GO:0031065
GO:0035794
GO:0043525
GO:0050731
GO:0090200
GO:0070245
GO:0045944
GO:0045893
GO:0000060
GO:0051262
GO:0051726
GO:0042127
GO:2000269
GO:1902253
GO:1902108
GO:0043523
GO:0070243
GO:0034103
GO:0006357
GO:0006355
GO:0001836
GO:0042493
GO:0010332
GO:0002931
GO:0006979
GO:0009651
GO:0009411
GO:0010165
GO:0009303
GO:0001756
GO:0033077
GO:0002360
GO:0002309
GO:0007179
Gene3D 2.60.40.720
4.10.170.10
InterPro IPR008967
IPR012346
IPR011615
IPR010991
IPR013872
IPR002117
PANTHER PTHR11447
Pfam PF00870
PF08563
PF07710
PRINTS PR00386
SUPFAM SSF47719
SSF49417
PROSITE PS00348

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010259

multicellular organismal aging

PMID:20818388[1]

ECO:0000315

P

When compared with p53+/+ mice, p53TSD/– mice had a significantly shorter lifespan and died by 6 weeks of age (Fig. 1c)

complete

GO:0090343

positive regulation of cell aging

PMID:20818388[1]

ECO:0000315

P

Furthermore, p53TSD/– mice exhibited a number of ageing-related phenotypes, including acute spine curvature (Fig. 1d), hypoplasia in the bone marrow (Fig. 2a) and lymphopenia and anaemia (Fig. 2c, d).

complete

GO:0071865

regulation of apoptosis in bone marrow

PMID:20818388[1]

ECO:0000315

P

Figure 2b Progressive degeneration of the haematopoietic system in p53TSD/– mice. LSK cells are progressively depleted in p53+/+ and p53TSD/– mice.

Note: a new more specific term (Positive regulation of apoptosis in haematopoietic stem cells) is suggested.

complete

GO:0071425

cell proliferation in bone marrow

PMID:20818388[1]

ECO:0000315

P

Figure 2 Progressive degeneration of the haematopoietic system in p53TSD/– mice. (b) LSK cells are progressively depleted in p53+/+ and p53TSD/– mice.

Note: a new more specific term (Negative regulation of hemopoietic stem cell proliferation) is suggested

complete

GO:0002902

regulation of B cell apoptosis

PMID:20818388[1]

ECO:0000315

P

Figure 2c. Lymphopenia in p53TSD/– mice. The number of T- and B-cells in the spleen of two-week-old p53TSD/– is decreased compared to wild type.

Note: a new more specific term (Negative regulation of B cell apoptosis) is suggested

complete

GO:0070232

regulation of T cell apoptosis

PMID:20818388[1]

ECO:0000315

P

Figure 2c. Lymphopenia in p53TSD/– mice. The number of T- and B-cells in the spleen of two-week-old p53TSD/– is decreased compared to wild type.


Note: a new more specific term (Negative regulation of T cell apoptosis) is suggested

complete

GO:0070245

positive regulation of thymocyte apoptosis

PMID:20818388[1]

ECO:0000315

P

The number of thymocytes was markedly reduced in p53TSD/– mice when compared with wild-type controls (Fig. 1f).

complete

GO:2000178

negative regulation of neural precursor cell proliferation

PMID:20818388[1]

ECO:0000315

P

Using Sox2, a marker specific for adult neural stem cells, we confirmed that neural stem cells are depleted in the dentate gyrus of one-month-old p53TSD/– mice (Fig. 3b).

complete

GO:2000019

negative regulation of male gonad development

PMID:20818388[1]

ECO:0000315

P

The size of the p53TSD/– mice testes became increasingly smaller (Testicular atrophy) (Fig. 4a, b).

complete

GO:0048133

male germ-line stem cell division

PMID:20818388[1]

ECO:0000315

P

The impaired spermatogenesis was because of the decreased number of SSCs (spermatogonial stem cells) (Epcam+, α6-integrin+ and c-Kit–) in the testes of p53TSD/– mice (Fig. 4c).


Note: a new more specific term (Negative regulation of male germ-line stem cell division) is suggested

complete

GO:0008630

DNA damage response, signal transduction resulting in induction of apoptosis

PMID:20818388[1]

ECO:0000315

P

Figure S2 DNA damage responses in thymocytes of different genotypes. (a) p53-dependent apoptosis in p53-/-, p53+/+, p53+/- and p53TSD/- thymocytes 10hrs after treating with 5, 10 and 20Gy of IR.

complete

GO:0050680

negative regulation of epithelial cell proliferation

PMID:20818388[1]

ECO:0000315

P

Figure S6 Apoptosis is significantly increased in the crypt of small intestine of p53TSD/- mice.

complete

GO:0042769

DNA damage response, detection of DNA damage

PMID:20818388[1]

ECO:0000315

P

Figure S2 DNA damage responses in thymocytes of different genotypes. (a) p53-dependent apoptosis in p53-/-, p53+/+, p53+/- and p53TSD/- thymocytes 10hrs after treating with 5, 10 and 20Gy of IR.

complete

GO:0008285

negative regulation of cell proliferation

PMID:20818388[1]

ECO:0000315

P

the p53TSD/– mice were similar to their wild-type littermates by 2 weeks of age, these mice became runted and weighed about 50% of the sex- and age-matched p53+/+- and p53+/–-mice by 4 weeks of age (Fig. 1a,b).

complete

GO:0010552

positive regulation of gene-specific transcription from RNA polymerase II promoter

PMID:20818388[1]

ECO:0000315

P

the expression of p53-target genes p21 and Puma in different tissues of p53TSD/– and wild-type mice were compared, including in brain, kidney, small intestine, liver, lung, skin and spleen. The mRNA levels of Puma and p21 were increased in most tissues of p53TSD/– mice, indicating that p53 is constitutively active in p53TSD/– mice (Supplementary Information, Fig. S2).

complete

GO:0030308

negative regulation of cell growth

PMID:20818388[1]

ECO:0000315

P

Figure 1B. Growth rate of p53+/+, p53+/– and p53TSD/– mice between 14 and 28 days postnatal show decreased growth.

complete

GO:0043065

positive regulation of apoptosis

PMID:20818388[1]

ECO:0000315

P

Figure S4e. Increased apoptosis of spermatogonia.

complete

GO:0070215

MDM2 binding

PMID:20818388[1]

ECO:0000021

UniProtKB:P23804


F

The TSD mutation partially disrupted the interaction between p53 and its negative regulator Mdm2, accounting for the increased p53 stability and activity in p53TSD/– cells (Fig. 1g, h and Supplementary Information, Fig. S1g).

complete

GO:0008380

RNA splicing

PMID:3023970[2]

ECO:0000314

P

Figure 3. The same RNA was inserted into an agrose gel with 2 different mice P53's. both showed bands for p53 and the RNA. This shows that the p53 is made from RNA splicing.

complete
CACAO 6342

GO:0000060

protein import into nucleus, translocation

PMID:11799106[3]

ECO:0000314

P

Figure 3 shows the N terminus (amino acids 1–68) contains two ubiquitination sites, two serine phosphorylation sites (Ser-32 and Ser-36) and five ankyrin repeats at the central region, followed by a PEST domain-containing C terminus

complete
CACAO 7550

enables

GO:0031625

ubiquitin protein ligase binding

PMID:24240685[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23804

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:24240685[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:D2J0Y4

F

Seeded From UniProt

complete

enables

GO:1990841

promoter-specific chromatin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

involved_in

GO:0062100

positive regulation of programmed necrotic cell death

PMID:27258785[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10361

P

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

PMID:23629966[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034644

cellular response to UV

PMID:23629966[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:23629966[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:22262176[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

PMID:22262176[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22262176[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16407291[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:16407291[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

PMID:16407291[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q99ML1)|has_regulation_target:(UniProtKB:Q9JM54)

Seeded From UniProt

complete

involved_in

GO:0071479

cellular response to ionizing radiation

PMID:16213212[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:16213212[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

PMID:24051492[10]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:24051492[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048512

circadian behavior

PMID:24051492[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043153

entrainment of circadian clock by photoperiod

PMID:24051492[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:24051492[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0097371

MDM2/MDM4 family protein binding

PMID:20818388[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23804

F

Seeded From UniProt

complete

involved_in

GO:0090343

positive regulation of cell aging

PMID:10562313[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070245

positive regulation of thymocyte apoptotic process

PMID:20818388[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:19749791[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:19749791[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:20818388[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008340

determination of adult lifespan

PMID:20818388[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:19749791[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:19749791[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097252

oligodendrocyte apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

involved_in

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

involved_in

GO:0007569

cell aging

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:12667443[13]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0097193)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

involved_in

GO:0000733

DNA strand renaturation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000772

regulation of cellular senescence

PMID:22904064[14]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2139971

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000379

positive regulation of reactive oxygen species metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000378

negative regulation of reactive oxygen species metabolic process

PMID:22044588[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

  • regulates_o_occurs_in:(EMAPA:16105)
  • regulates_o_occurs_in:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000279

negative regulation of DNA biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000269

regulation of fibroblast apoptotic process

PMID:17116431[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1927345

P

Seeded From UniProt

complete

enables

GO:1990841

promoter-specific chromatin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1990144

intrinsic apoptotic signaling pathway in response to hypoxia

PMID:20935145[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904024

negative regulation of glucose catabolic process to lactate via pyruvate

PMID:20935145[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0000746)
  • regulates_o_occurs_in:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903799

negative regulation of production of miRNAs involved in gene silencing by miRNA

PMID:21522133[18]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1890508

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903205

regulation of hydrogen peroxide-induced cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902253

regulation of intrinsic apoptotic signaling pathway by p53 class mediator

PMID:17571083[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902108

regulation of mitochondrial membrane permeability involved in apoptotic process

PMID:14963330[20]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901525

negative regulation of mitophagy

PMID:22044588[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

  • regulates_o_occurs_in:(EMAPA:16105)
  • regulates_o_occurs_in:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900119

positive regulation of execution phase of apoptosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

enables

GO:0097718

disordered domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0097371

MDM2/MDM4 family protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097252

oligodendrocyte apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090403

oxidative stress-induced premature senescence

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090399

replicative senescence

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072717

cellular response to actinomycin D

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072363

regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter

PMID:20935145[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_has_input:(MGI:MGI:2442752)
  • regulates_o_occurs_in:(CL:0000746)
  • occurs_in:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:20434500[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2442860

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:16107883[22]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:12135983[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072331

signal transduction by p53 class mediator

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071850

mitotic cell cycle arrest

PMID:17515607[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071494

cellular response to UV-C

PMID:24014029[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108090

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071480

cellular response to gamma radiation

PMID:10710310[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071480

cellular response to gamma radiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071479

cellular response to ionizing radiation

PMID:16286009[27]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1096393
MGI:MGI:2181667

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071479

cellular response to ionizing radiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071158

positive regulation of cell cycle arrest

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070266

necroptotic process

PMID:22726440[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2145814

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070245

positive regulation of thymocyte apoptotic process

PMID:17210642[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

  • regulates_o_occurs_in:(EMAPA:18768)
  • regulates_o_occurs_in:(CL:0000807)|regulates_o_occurs_in:(EMAPA:18768)
  • regulates_o_occurs_in:(CL:0000808)|regulates_o_occurs_in:(EMAPA:18768)
  • regulates_o_occurs_in:(CL:0000809)|regulates_o_occurs_in:(EMAPA:18768)
  • regulates_o_occurs_in:(CL:0000810)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070243

regulation of thymocyte apoptotic process

PMID:17210642[29]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1328362

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:12952892[30]

ECO:0000315

P

Figure 1 A shows DNA damage-induced apoptosis of E1A-expressing MEFs. MEFs were infected with control (pBabe) or E1A-expressing retrovirus (pBabe-E1A), and were treated with adriamycin (0.25 μg/mL) for 24 h. Wild-type (WT) and Noxa-/- MEFs (left), as well as Noxa-/- and Noxa-/-/Bax-/- MEFs (right), were each prepared from the same litter. Results are representative of three independent experiments.

complete
CACAO 9419

acts_upstream_of_or_within

GO:0065003

protein-containing complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

PMID:20935145[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(CL:0000746)
  • regulates_o_has_input:(MGI:MGI:2442752)
  • occurs_in:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060411

cardiac septum morphogenesis

PMID:22821713[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107934
MGI:MGI:96952

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051974

negative regulation of telomerase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051726

regulation of cell cycle

PMID:18332125[32]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109583

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051726

regulation of cell cycle

PMID:15898111[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

Seeded From UniProt

complete

enables

GO:0051721

protein phosphatase 2A binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051453

regulation of intracellular pH

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:15485914[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97740

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:17591690[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051289

protein homotetramerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051276

chromosome organization

PMID:17200209[36]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88039

P

occurs_in:(EMAPA:32874)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051276

chromosome organization

PMID:17053789[37]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1920086
MGI:MGI:2141503

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051123

RNA polymerase II preinitiation complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050821

protein stabilization

PMID:18625840[38]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:106184

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048662

negative regulation of smooth muscle cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048568

embryonic organ development

PMID:17470788[39]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:894835

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048147

negative regulation of fibroblast proliferation

PMID:17332504[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048147

negative regulation of fibroblast proliferation

PMID:12952892[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1926340

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048147

negative regulation of fibroblast proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22362889[41]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2683584

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21159655[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

has_regulation_target:(MGI:MGI:1916577)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20434500[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:2442860)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8183579[43]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:7677753[44]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21159655[42]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:1916577)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20368352[45]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:1930146)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19411634[46]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16107883[22]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:108027)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16098148[47]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045930

negative regulation of mitotic cell cycle

PMID:8612582[48]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:87859

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15735665[49]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2146189

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:16044147[50]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15735665[49]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045861

negative regulation of proteolysis

PMID:23277542[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045787

positive regulation of cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0043621

protein self-association

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:16777961[52]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1927345

P

occurs_in:(EMAPA:16895)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:10911993[53]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1335098

P

  • occurs_in:(EMAPA:17544)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:9608530[54]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

  • occurs_in:(EMAPA:18441)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:15483136[55]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:11150333[56]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

  • occurs_in:(EMAPA:16910)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:11092819[57]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

  • occurs_in:(EMAPA:16910)
  • regulates_o_occurs_in:(CL:0000540)|occurs_in(EMAPA:16910)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:10894779[58]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043523

regulation of neuron apoptotic process

PMID:15483136[55]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1336991

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043516

regulation of DNA damage response, signal transduction by p53 class mediator

PMID:21522133[18]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1890508

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043504

mitochondrial DNA repair

PMID:24101517[59]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3528279

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8183579[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:17912366[60]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857989

P

regulates_o_occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:9024662[61]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:16571598[62]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102845
MGI:MGI:99702

P

occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:17068116[63]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

occurs_in:(EMAPA:17023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:17476307[64]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109337

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:16286009[27]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1096393

P

occurs_in:(CL:0000763)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:15983387[65]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2442925

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:15983387[65]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1336991

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:16777961[52]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

occurs_in:(EMAPA:16895)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:12952892[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1926340

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:12135983[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:14654789[66]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:9098922[67]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:16039)|occurs_in:(EMAPA:16039)|occurs_in:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042149

cellular response to glucose starvation

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

PMID:10805805[68]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:87859

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

PMID:10716720[69]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88039

P

occurs_in:(EMAPA:32874)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

PMID:12878730[70]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

Seeded From UniProt

complete

part_of

GO:0035861

site of double-strand break

PMID:24550317[71]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035794

positive regulation of mitochondrial membrane permeability

PMID:22726440[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2145814

P

regulates_o_occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035264

multicellular organism growth

PMID:17325035[72]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1343101

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035264

multicellular organism growth

PMID:17116431[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1927345

P

Seeded From UniProt

complete

enables

GO:0035035

histone acetyltransferase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0035033

histone deacetylase regulator activity

PMID:15657445[73]

ECO:0000314

direct assay evidence used in manual assertion

F

regulates_o_has_input:(MGI:MGI:87951)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034644

cellular response to UV

PMID:14963330[20]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034644

cellular response to UV

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034614

cellular response to reactive oxygen species

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034613

cellular protein localization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034103

regulation of tissue remodeling

PMID:22044588[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

regulates_o_occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033077

T cell differentiation in thymus

PMID:16357222[74]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98159

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031571

mitotic G1 DNA damage checkpoint

PMID:16107883[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031571

mitotic G1 DNA damage checkpoint

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031497

chromatin assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031065

positive regulation of histone deacetylation

PMID:15657445[73]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030971

receptor tyrosine kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:15657445[73]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:17476307[64]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109337

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:16199867[75]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:106184

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:11884608[76]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:11790307[77]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030330

DNA damage response, signal transduction by p53 class mediator

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030308

negative regulation of cell growth

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021549

cerebellum development

PMID:24013501[78]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019903

protein phosphatase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

colocalizes_with

GO:0016604

nuclear body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016032

viral process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010666

positive regulation of cardiac muscle cell apoptotic process

PMID:22044588[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

  • regulates_o_occurs_in:(EMAPA:16105)
  • regulates_o_occurs_in:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

PMID:18625840[38]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:106184

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

PMID:17068116[63]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

occurs_in:(EMAPA:17023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

PMID:14744935[79]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000817)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010165

response to X-ray

PMID:22821713[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010165

response to X-ray

PMID:11884608[76]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009792

embryo development ending in birth or egg hatching

PMID:16702401[80]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2138319

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009651

response to salt stress

PMID:16571598[62]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102845
MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009411

response to UV

PMID:12952892[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1926340

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009411

response to UV

PMID:11092819[57]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009411

response to UV

PMID:10815637[81]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

has_participant:(EMAPA:32834)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009411

response to UV

PMID:14744935[79]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009303

rRNA transcription

PMID:18809582[82]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104738

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009299

mRNA transcription

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:23935987[83]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1915333

P

occurs_in:(EMAPA:17362)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:16107883[22]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108027

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:11246230[84]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:10973261[85]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:10591653[86]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:10591652[87]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008156

negative regulation of DNA replication

PMID:11884608[76]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1926340

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008156

negative regulation of DNA replication

PMID:11884608[76]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008104

protein localization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007569

cell aging

PMID:17053789[37]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1920086

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007569

cell aging

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:22821713[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107934
MGI:MGI:96952

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007417

central nervous system development

PMID:16199867[75]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1335098

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007406

negative regulation of neuroblast proliferation

PMID:9608530[54]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007369

gastrulation

PMID:17000767[88]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98159

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007275

multicellular organism development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:18212064[89]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108051
MGI:MGI:894293
MGI:MGI:98725

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007050

cell cycle arrest

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006983

ER overload response

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:22726440[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2145814

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:17591690[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

PMID:10710310[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

PMID:16107883[22]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108027

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:17591690[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:12952892[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1926340

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:11092819[57]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

  • occurs_in:(EMAPA:16910)
  • occurs_in:(CL:0000540)|occurs_in:(EMAPA:16910)
  • occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:15383658[90]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:14744935[79]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:17325035[72]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1343101

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:16183742[91]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006914

autophagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006606

protein import into nucleus

PMID:11799106[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006357

regulation of transcription by RNA polymerase II

PMID:24013501[78]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

PMID:12135983[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006302

double-strand break repair

PMID:17912366[60]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857989

P

occurs_in:(CL:0000017)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006289

nucleotide-excision repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11799106[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:24101517[59]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:22726440[28]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:24101517[59]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12524542[92]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000586)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11900485[93]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11799106[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

colocalizes_with

GO:0005669

transcription factor TFIID complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

C

Seeded From UniProt

complete

part_of

GO:0005657

replication fork

PMID:15364958[94]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18545656[95]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18332125[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17591690[35]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:14729462[96]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12524542[92]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000586)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11900485[93]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11799106[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24101517[59]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17571083[19]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10361

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:16098148[47]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:16044147[50]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:12135983[23]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:20434500[21]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(MGI:MGI:2442860)

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:18212064[89]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:87951)

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:15657445[73]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:87951)

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:16363065[97]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:16107883[22]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:108027)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:12135983[23]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:10205143[98]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:87963)|has_participant:(MGI:MGI:87964)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002931

response to ischemia

PMID:22044588[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857263

P

occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002687

positive regulation of leukocyte migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002360

T cell lineage commitment

PMID:8788039[99]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

  • occurs_in:(EMAPA:18768)
  • occurs_in:(CL:0000084)|occurs_in:(EMAPA:32760)
  • occurs_in:(CL:0000084)|occurs_in:(EMAPA:18767)
  • occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002326

B cell lineage commitment

PMID:8788039[99]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857590

P

  • occurs_in:(EMAPA:18768)
  • results_in_commitment_to:(CL:0000236)|occurs_in(EMAPA:32760)
  • results_in_commitment_to:(CL:0000236)|occurs_in(EMAPA:18767)
  • results_in_commitment_to:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002309

T cell proliferation involved in immune response

PMID:16357222[74]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98159

P

Seeded From UniProt

complete

enables

GO:0002039

p53 binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0002020

protease binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:14963330[20]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:15483136[55]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001756

somitogenesis

PMID:17320900[100]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1343101

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001701

in utero embryonic development

PMID:9288110[101]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:101816

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001701

in utero embryonic development

PMID:17325035[72]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1343101

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001701

in utero embryonic development

PMID:10567591[102]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1099436

P

Seeded From UniProt

complete

NOT|acts_upstream_of_or_within

GO:0001701

in utero embryonic development

PMID:9425892[103]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:101816

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:16286009[27]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1096393

F

has_regulation_target:(MGI:MGI:2181667)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:21300779[104]

ECO:0000314

direct assay evidence used in manual assertion

F

  • occurs_in:(CL:0000018)
  • has_regulation_target:(MGI:MGI:1920722)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:21159655[42]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(MGI:MGI:1916577)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0001221

transcription cofactor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

F

Seeded From UniProt

complete

enables

GO:0001094

TFIID-class transcription factor complex binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0001085

RNA polymerase II transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0001046

core promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:24013501[78]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:22737085[105]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:16846)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21159655[42]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(MGI:MGI:1916577)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:22897442[106]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

C

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3889

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000733

DNA strand renaturation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:19411634[46]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95661

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18212064[89]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98725

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15657445[73]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:106203

P

has_regulation_target:(MGI:MGI:87951)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:8183579[43]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04637

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:K7PPA8
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:1990841

promoter-specific chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:1900119

positive regulation of execution phase of apoptosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0097718

disordered domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0097252

oligodendrocyte apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0090403

oxidative stress-induced premature senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0090399

replicative senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0072717

cellular response to actinomycin D

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0072331

signal transduction by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0071480

cellular response to gamma radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0071479

cellular response to ionizing radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0071158

positive regulation of cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0060218

hematopoietic stem cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0051974

negative regulation of telomerase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0051721

protein phosphatase 2A binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0051123

RNA polymerase II preinitiation complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0048539

bone marrow development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0048147

negative regulation of fibroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0043621

protein self-association

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0035035

histone acetyltransferase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0034644

cellular response to UV

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

involved_in

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0031571

mitotic G1 DNA damage checkpoint

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0031497

chromatin assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0030971

receptor tyrosine kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0030330

DNA damage response, signal transduction by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0019903

protein phosphatase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0010332

response to gamma radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0009299

mRNA transcription

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0008104

protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0007569

cell aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0006983

ER overload response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0005669

transcription factor TFIID complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

enables

GO:0002039

p53 binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0002020

protease binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0001094

TFIID-class transcription factor complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0001085

RNA polymerase II transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0001046

core promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

C

Seeded From UniProt

complete

involved_in

GO:0000733

DNA strand renaturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04637
ensembl:ENSP00000269305

P

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:2000279

negative regulation of DNA biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:1903205

regulation of hydrogen peroxide-induced cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

enables

GO:0097371

MDM2/MDM4 family protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

F

Seeded From UniProt

complete

involved_in

GO:0071417

cellular response to organonitrogen compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0055093

response to hyperoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0051453

regulation of intracellular pH

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0048662

negative regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0045787

positive regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

F

Seeded From UniProt

complete

involved_in

GO:0043200

response to amino acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0034614

cellular response to reactive oxygen species

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0034605

cellular response to heat

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0033552

response to vitamin B3

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0032526

response to retinoic acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

F

Seeded From UniProt

complete

involved_in

GO:0031000

response to caffeine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0010243

response to organonitrogen compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0010224

response to UV-B

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0010165

response to X-ray

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0010038

response to metal ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0010035

response to inorganic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0009411

response to UV

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

F

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

C

Seeded From UniProt

complete

involved_in

GO:0002687

positive regulation of leukocyte migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

P

Seeded From UniProt

complete

enables

GO:0001221

transcription cofactor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

F

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10361
ensembl:ENSRNOP00000074031

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR012346

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR012346

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002117

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011615

F

Seeded From UniProt

complete

involved_in

GO:0051262

protein tetramerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010991
InterPro:IPR036674

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

involved_in

GO:0012501

programmed cell death

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1210

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 Liu, D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat. Cell Biol. 12 993-8 PubMed GONUTS page
  2. ↑ Arai, N et al. (1986) Immunologically distinct p53 molecules generated by alternative splicing. Mol. Cell. Biol. 6 3232-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Chang, NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J. Biol. Chem. 277 10323-31 PubMed GONUTS page
  4. ↑ 4.0 4.1 Yan, S et al. (2014) FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. Oncogene 33 5424-33 PubMed GONUTS page
  5. ↑ Wang, K et al. (2016) The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873. Cell Death Differ. 23 1394-405 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Morgado-Palacin, L et al. (2012) Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells. Cell Cycle 11 503-10 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Li, J et al. (2006) Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281 7260-70 PubMed GONUTS page
  9. ↑ 9.0 9.1 Takagi, M et al. (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123 49-63 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 Miki, T et al. (2013) p53 regulates Period2 expression and the circadian clock. Nat Commun 4 2444 PubMed GONUTS page
  11. ↑ Hudson, JD et al. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. J. Exp. Med. 190 1375-82 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 12.3 Montano, X (2009) Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. Oncogene 28 3787-800 PubMed GONUTS page
  13. ↑ Mihara, M et al. (2003) p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11 577-90 PubMed GONUTS page
  14. ↑ Neault, M et al. (2012) Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 40 9513-21 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 15.3 15.4 Hoshino, A et al. (2012) p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J. Mol. Cell. Cardiol. 52 175-84 PubMed GONUTS page
  16. ↑ 16.0 16.1 Adam, J et al. (2007) A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst.) 6 224-34 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 17.3 Kimata, M et al. (2010) p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress. Am. J. Physiol. Heart Circ. Physiol. 299 H1908-16 PubMed GONUTS page
  18. ↑ 18.0 18.1 Ugalde, AP et al. (2011) Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J. 30 2219-32 PubMed GONUTS page
  19. ↑ 19.0 19.1 Tan, Z et al. (2007) Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ. 14 1721-32 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 Chipuk, JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 1010-4 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Brosh, R et al. (2010) p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. FEBS Lett. 584 2473-7 PubMed GONUTS page
  22. ↑ 22.0 22.1 22.2 22.3 22.4 22.5 Doumont, G et al. (2005) G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. EMBO J. 24 3093-103 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 23.3 23.4 Bourdon, JC et al. (2002) Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J. Cell Biol. 158 235-46 PubMed GONUTS page
  24. ↑ Nakaya, N et al. (2007) noxin, a novel stress-induced gene involved in cell cycle and apoptosis. Mol. Cell. Biol. 27 5430-44 PubMed GONUTS page
  25. ↑ Sung, YH et al. (2013) Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation. J. Biol. Chem. 288 31261-7 PubMed GONUTS page
  26. ↑ 26.0 26.1 Hirao, A et al. (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287 1824-7 PubMed GONUTS page
  27. ↑ 27.0 27.1 27.2 Wu, WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123 641-53 PubMed GONUTS page
  28. ↑ 28.0 28.1 28.2 28.3 Vaseva, AV et al. (2012) p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149 1536-48 PubMed GONUTS page
  29. ↑ 29.0 29.1 Babbe, H et al. (2007) The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol. Cell. Biol. 27 1947-59 PubMed GONUTS page
  30. ↑ 30.0 30.1 30.2 30.3 30.4 Shibue, T et al. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev. 17 2233-8 PubMed GONUTS page
  31. ↑ 31.0 31.1 31.2 Zhang, Q et al. (2012) Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development. J. Pathol. 228 416-28 PubMed GONUTS page
  32. ↑ 32.0 32.1 Chang, CJ et al. (2008) PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol. Cell. Biol. 28 3281-9 PubMed GONUTS page
  33. ↑ Kalitsis, P et al. (2005) Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer 44 29-36 PubMed GONUTS page
  34. ↑ Sugo, N et al. (2004) p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Mol. Cell. Biol. 24 9470-7 PubMed GONUTS page
  35. ↑ 35.0 35.1 35.2 35.3 Lee, JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell. Sci. 120 2259-71 PubMed GONUTS page
  36. ↑ Alberici, P et al. (2007) Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am. J. Pathol. 170 377-87 PubMed GONUTS page
  37. ↑ 37.0 37.1 He, H et al. (2006) POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J. 25 5180-90 PubMed GONUTS page
  38. ↑ 38.0 38.1 Bonetti, P et al. (2008) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J. Cell Biol. 182 19-26 PubMed GONUTS page
  39. ↑ Li, L et al. (2007) PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc. Natl. Acad. Sci. U.S.A. 104 7951-6 PubMed GONUTS page
  40. ↑ Takahashi, K et al. (2007) Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol. Biol. Cell 18 1701-9 PubMed GONUTS page
  41. ↑ Adams, CJ et al. (2012) The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proc. Natl. Acad. Sci. U.S.A. 109 3778-83 PubMed GONUTS page
  42. ↑ 42.0 42.1 42.2 42.3 Sung, YH et al. (2010) Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response. Cancer Res. 70 10454-63 PubMed GONUTS page
  43. ↑ 43.0 43.1 43.2 Miyashita, T et al. (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9 1799-805 PubMed GONUTS page
  44. ↑ Sato, H et al. (1995) Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem. Biophys. Res. Commun. 214 468-74 PubMed GONUTS page
  45. ↑ Yuan, Z et al. (2010) The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol. Cell. Biol. 30 3004-15 PubMed GONUTS page
  46. ↑ 46.0 46.1 Trainor, CD et al. (2009) GATA-1 associates with and inhibits p53. Blood 114 165-73 PubMed GONUTS page
  47. ↑ 47.0 47.1 Watanabe-Fukunaga, R et al. (2005) SEI family of nuclear factors regulates p53-dependent transcriptional activation. Genes Cells 10 851-60 PubMed GONUTS page
  48. ↑ Wen, ST et al. (1996) The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 15 1583-95 PubMed GONUTS page
  49. ↑ 49.0 49.1 Lin, L et al. (2005) topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage. Oncogene 24 3385-96 PubMed GONUTS page
  50. ↑ 50.0 50.1 Tomasini, R et al. (2005) TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene 24 8093-104 PubMed GONUTS page
  51. ↑ Zhang, Q et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 110 978-83 PubMed GONUTS page
  52. ↑ 52.0 52.1 Orii, KE et al. (2006) Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc. Natl. Acad. Sci. U.S.A. 103 10017-22 PubMed GONUTS page
  53. ↑ Frank, KM et al. (2000) DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol. Cell 5 993-1002 PubMed GONUTS page
  54. ↑ 54.0 54.1 Vogel, KS & Parada, LF (1998) Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin. Mol. Cell. Neurosci. 11 19-28 PubMed GONUTS page
  55. ↑ 55.0 55.1 55.2 Lee, AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J. Neurosci. 24 9174-84 PubMed GONUTS page
  56. ↑ Zaidi, AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J. Neurosci. 21 169-75 PubMed GONUTS page
  57. ↑ 57.0 57.1 57.2 D'Sa-Eipper, C et al. (2001) DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development 128 137-46 PubMed GONUTS page
  58. ↑ Pozniak, CD et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289 304-6 PubMed GONUTS page
  59. ↑ 59.0 59.1 59.2 59.3 Zhuang, J et al. (2013) Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc. Natl. Acad. Sci. U.S.A. 110 17356-61 PubMed GONUTS page
  60. ↑ 60.0 60.1 Paul, C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE 2 e989 PubMed GONUTS page
  61. ↑ Yin, C et al. (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385 637-40 PubMed GONUTS page
  62. ↑ 62.0 62.1 Fan, H et al. (2006) Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am. J. Physiol. Renal Physiol. 291 F670-82 PubMed GONUTS page
  63. ↑ 63.0 63.1 Przemeck, SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G620-7 PubMed GONUTS page
  64. ↑ 64.0 64.1 Frappart, PO et al. (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J. 26 2732-42 PubMed GONUTS page
  65. ↑ 65.0 65.1 Ishii, H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102 9655-60 PubMed GONUTS page
  66. ↑ Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page
  67. ↑ Wlodarczyk, BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54 284-97 PubMed GONUTS page
  68. ↑ Whang, YE et al. (2000) c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proc. Natl. Acad. Sci. U.S.A. 97 5486-91 PubMed GONUTS page
  69. ↑ Halberg, RB et al. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc. Natl. Acad. Sci. U.S.A. 97 3461-6 PubMed GONUTS page
  70. ↑ Fingerle-Rowson, G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc. Natl. Acad. Sci. U.S.A. 100 9354-9 PubMed GONUTS page
  71. ↑ Khoury-Haddad, H et al. (2014) PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 111 E728-37 PubMed GONUTS page
  72. ↑ 72.0 72.1 72.2 Bu, P et al. (2007) Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol. Cell. Biol. 27 3405-16 PubMed GONUTS page
  73. ↑ 73.0 73.1 73.2 73.3 73.4 Wilkinson, DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol. Cell. Biol. 25 1200-12 PubMed GONUTS page
  74. ↑ 74.0 74.1 Sulic, S et al. (2005) Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes Dev. 19 3070-82 PubMed GONUTS page
  75. ↑ 75.0 75.1 Colombo, E et al. (2005) Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol. Cell. Biol. 25 8874-86 PubMed GONUTS page
  76. ↑ 76.0 76.1 76.2 76.3 Shimura, T et al. (2002) p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm. Mol. Cell. Biol. 22 2220-8 PubMed GONUTS page
  77. ↑ Weiss, RS et al. (2002) Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr. Biol. 12 73-7 PubMed GONUTS page
  78. ↑ 78.0 78.1 78.2 Hamard, PJ et al. (2013) The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 27 1868-85 PubMed GONUTS page
  79. ↑ 79.0 79.1 79.2 Qu, L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18 261-77 PubMed GONUTS page
  80. ↑ Vives, V et al. (2006) ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev. 20 1262-7 PubMed GONUTS page
  81. ↑ Hendry, JH et al. (2000) Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation. Int. J. Radiat. Biol. 76 559-65 PubMed GONUTS page
  82. ↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
  83. ↑ Ross, AP et al. (2013) A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PLoS ONE 8 e69333 PubMed GONUTS page
  84. ↑ Bajenaru, ML et al. (2001) Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33 314-23 PubMed GONUTS page
  85. ↑ Reilly, KM et al. (2000) Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat. Genet. 26 109-13 PubMed GONUTS page
  86. ↑ Vogel, KS et al. (1999) Mouse tumor model for neurofibromatosis type 1. Science 286 2176-9 PubMed GONUTS page
  87. ↑ Cichowski, K et al. (1999) Mouse models of tumor development in neurofibromatosis type 1. Science 286 2172-6 PubMed GONUTS page
  88. ↑ Panić, L et al. (2006) Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol. Cell. Biol. 26 8880-91 PubMed GONUTS page
  89. ↑ 89.0 89.1 89.2 Wilkinson, DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol. Cell. Biol. 28 1988-98 PubMed GONUTS page
  90. ↑ You, H et al. (2004) p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc. Natl. Acad. Sci. U.S.A. 101 14057-62 PubMed GONUTS page
  91. ↑ Berube, C et al. (2005) Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc. Natl. Acad. Sci. U.S.A. 102 14314-20 PubMed GONUTS page
  92. ↑ 92.0 92.1 Takeuchi, A et al. (2003) Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat. Genet. 33 172-6 PubMed GONUTS page
  93. ↑ 93.0 93.1 Wadhwa, R et al. (2002) Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp. Cell Res. 274 246-53 PubMed GONUTS page
  94. ↑ Sengupta, S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J. Cell Biol. 166 801-13 PubMed GONUTS page
  95. ↑ Park, JY et al. (2008) Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice. PLoS ONE 3 e2346 PubMed GONUTS page
  96. ↑ Zhang, S et al. (2004) Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus. Exp. Cell Res. 293 248-58 PubMed GONUTS page
  97. ↑ Kulesz-Martin, M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J. Investig. Dermatol. Symp. Proc. 10 142-52 PubMed GONUTS page
  98. ↑ Leri, A et al. (1999) Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice. Circ. Res. 84 752-62 PubMed GONUTS page
  99. ↑ 99.0 99.1 Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page
  100. ↑ Nueda, ML et al. (2007) The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells. J. Mol. Biol. 367 1281-93 PubMed GONUTS page
  101. ↑ Cranston, A et al. (1997) Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat. Genet. 17 114-8 PubMed GONUTS page
  102. ↑ Shu, Z et al. (1999) Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background. Mol. Cell. Biol. 19 8686-93 PubMed GONUTS page
  103. ↑ Toft, NJ et al. (1998) No female embryonic lethality in mice nullizygous for Msh2 and p53. Nat. Genet. 18 17 PubMed GONUTS page
  104. ↑ Bornstein, C et al. (2011) SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Mol. Cell. Biol. 31 1679-89 PubMed GONUTS page
  105. ↑ Bochkis, IM et al. (2012) Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 8 e1002770 PubMed GONUTS page
  106. ↑ Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page
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