HUMAN:FLOT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FLOT1
Protein Name(s)	Flotillin-1
External Links
UniProt	O75955
EMBL	AF089750 AF085357 BA000025 AK301291 AL662797 BC001146 AF117234
CCDS	CCDS4688.1
RefSeq	NP_005794.1 XP_005248837.1 XP_005248838.1 XP_005272816.1 XP_005272817.1 XP_005274966.1 XP_005274967.1 XP_005275392.1 XP_005275393.1 XP_005275559.1 XP_005275560.1
UniGene	Hs.179986
ProteinModelPortal	O75955
SMR	O75955
BioGrid	115506
IntAct	O75955
MINT	MINT-3002104
STRING	9606.ENSP00000372873
PhosphoSite	O75955
MaxQB	O75955
PaxDb	O75955
PRIDE	O75955
DNASU	10211
Ensembl	ENST00000376389 ENST00000383382 ENST00000383562 ENST00000436822 ENST00000444632
GeneID	10211
KEGG	hsa:10211
UCSC	uc003nrm.3
CTD	10211
GeneCards	GC06M030695 GC06Mj30685 GC06Mk30685 GC06Mn30685 GC06Mo30686
H-InvDB	HIX0166980
HGNC	HGNC:3757
HPA	CAB007766 HPA001393
MIM	606998
neXtProt	NX_O75955
PharmGKB	PA28175
eggNOG	COG2268
HOGENOM	HOG000240804
HOVERGEN	HBG051628
InParanoid	O75955
KO	K07192
OMA	ERQYDSE
PhylomeDB	O75955
TreeFam	TF324879
ChiTaRS	FLOT1
GeneWiki	FLOT1
GenomeRNAi	10211
NextBio	35475588
PRO	PR:O75955
Proteomes	UP000005640 UP000005640
Bgee	O75955
CleanEx	HS_FLOT1
ExpressionAtlas	O75955
Genevestigator	O75955
GO	GO:0005901 GO:0034451 GO:0005768 GO:0070062 GO:0016600 GO:0005925 GO:0016021 GO:0005765 GO:0042470 GO:0016020 GO:0045121 GO:0005815 GO:0042383 GO:0002020 GO:0007409 GO:0090002 GO:0022617 GO:0035023
InterPro	IPR001107 IPR027705
PANTHER	PTHR13806
Pfam	PF01145
SMART	SM00244

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0071806	beta-amyloid formation	PMID:24465508^[1]	ECO:0000315			P		Figure 1: flow cytometry of knockout cells show decreased APP endocytosis.	complete CACAO 9407
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:23319823^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:25468996^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032226	positive regulation of synaptic transmission, dopaminergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08917	P	has_input:(UniProtKB:Q01959) happens_during:(GO:0070528)	Seeded From UniProt	complete
involved_in	GO:0044854	plasma membrane raft assembly	PMID:21399631^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	PMID:21399631^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:21399631^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21399631^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:21399631^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002090	regulation of receptor internalization	PMID:21399631^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q01959) happens_during:(GO:0070528) has_input:(UniProtKB:P43004)	Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	PMID:21399631^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q01959) happens_during:(GO:0070528) has_input:(UniProtKB:P43004)	Seeded From UniProt	complete
involved_in	GO:0070528	protein kinase C signaling	PMID:21399631^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044291	cell-cell contact zone	PMID:23983584^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:23983584^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt	complete
NOT\|part_of	GO:0016324	apical plasma membrane	PMID:23983584^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:23983584^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	PMID:21696602^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21696602^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q14254	F		Seeded From UniProt	complete
part_of	GO:0001931	uropod	PMID:21696602^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
involved_in	GO:1901890	positive regulation of cell junction assembly	PMID:24046456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P12830)	Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:24046456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P12830) has_regulation_target:(UniProtKB:O60716)	Seeded From UniProt	complete
involved_in	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	PMID:24046456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:1901741	positive regulation of myoblast fusion	PMID:24046456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:24046456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21696602^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:25893292^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:24046456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P12830) has_input:(UniProtKB:O60716) occurs_at:(GO:0005913)	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:24046456^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0030864	cortical actin cytoskeleton	PMID:24046456^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:24046456^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	PMID:24046456^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1903044	protein localization to membrane raft	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) has_input:(UniProtKB:Q14254) has_input:(UniProtKB:Q03135) has_input:(UniProtKB:Q6NZI2) has_input:(UniProtKB:O94905) has_input:(UniProtKB:P45880-2) has_input:(UniProtKB:P50454) has_input:(UniProtKB:P00558) has_input:(UniProtKB:O95810) has_input:(UniProtKB:P07195) has_input:(UniProtKB:P07339) has_input:(UniProtKB:P18206-2)	Seeded From UniProt	complete
involved_in	GO:0001765	membrane raft assembly	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	PMID:25204797^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033227	dsRNA transport	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000842) has_agent:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0060355	positive regulation of cell adhesion molecule production	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115) happens_during:(GO:0034138) has_input:(UniProtKB:P19320) has_input:(UniProtKB:P05362)	Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115) happens_during:(GO:0034138)	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115) happens_during:(GO:0034138) has_input:(UniProtKB:P02778)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115) happens_during:(GO:0034138) has_input:(UniProtKB:Q14653)	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q14254)\|has_input:(UniProtKB:Q03135)	Seeded From UniProt	complete
involved_in	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
NOT\|involved_in	GO:0034143	regulation of toll-like receptor 4 signaling pathway	PMID:25204797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0022617	extracellular matrix disassembly	PMID:21119006^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:15469992^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034451	centriolar satellite	PMID:18000879^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	PMID:18000879^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:24612608^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P56817)	Seeded From UniProt	complete
colocalizes_with	GO:0008180	COP9 signalosome	PMID:18850735^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:20682791^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:17897319^[21]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:24612608^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:21399631^[4]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002691)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:21399631^[4]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002691)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:21399631^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002691)	Seeded From UniProt	complete
involved_in	GO:0051580	regulation of neurotransmitter uptake	PMID:21399631^[4]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098691) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002691)	Seeded From UniProt	complete
involved_in	GO:0051580	regulation of neurotransmitter uptake	PMID:21399631^[4]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098691) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002691)	Seeded From UniProt	complete
involved_in	GO:0051580	regulation of neurotransmitter uptake	PMID:21399631^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098691) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002691)	Seeded From UniProt	complete
involved_in	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:1901890	positive regulation of cell junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:1901741	positive regulation of myoblast fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:0070528	protein kinase C signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:0032226	positive regulation of synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	C		Seeded From UniProt	complete
involved_in	GO:0002090	regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08917 ensembl:ENSMUSP00000001569	P		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	C		Seeded From UniProt	complete
part_of	GO:0048786	presynaptic active zone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	F		Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E1 ensembl:ENSRNOP00000071275	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9153235^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:9153235^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bitsikas, V et al. (2014) The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice. PLoS ONE 9 e85217 PubMed GONUTS page
↑ Gong, H et al. (2013) Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma. Clin. Cancer Res. 19 1083-93 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Cremona, ML et al. (2011) Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat. Neurosci. 14 469-77 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gauss, A et al. (2013) Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases. Int J Med Sci 10 1259-70 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Affentranger, S et al. (2011) Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes. BMC Cell Biol. 12 28 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Guillaume, E et al. (2013) Flotillin microdomains stabilize cadherins at cell-cell junctions. J. Cell. Sci. 126 5293-304 PubMed GONUTS page
↑ Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^14.0 ^14.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Cornfine, S et al. (2011) The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Mol. Biol. Cell 22 202-15 PubMed GONUTS page
↑ Bared, SM et al. (2004) Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Mol. Biol. Cell 15 5399-407 PubMed GONUTS page
↑ ^17.0 ^17.1 Oeffner, F et al. (2008) Novel interaction partners of Bardet-Biedl syndrome proteins. Cell Motil. Cytoskeleton 65 143-55 PubMed GONUTS page
↑ ^18.0 ^18.1 John, BA et al. (2014) Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting. FEBS J. 281 2074-87 PubMed GONUTS page
↑ Fang, L et al. (2008) Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J. Proteome Res. 7 4914-25 PubMed GONUTS page
↑ Gorbea, C et al. (2010) A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J. Biol. Chem. 285 31616-33 PubMed GONUTS page
↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
↑ ^22.0 ^22.1 Bickel, PE et al. (1997) Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem. 272 13793-802 PubMed GONUTS page

[PMID:24465508-1] Bitsikas, V et al. (2014) The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice. PLoS ONE 9 e85217 PubMed GONUTS page

[PMID:23319823-2] Gong, H et al. (2013) Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma. Clin. Cancer Res. 19 1083-93 PubMed GONUTS page

[PMID:25468996-3] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:21399631-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Cremona, ML et al. (2011) Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat. Neurosci. 14 469-77 PubMed GONUTS page

[PMID:23983584-5] 5.0 ^5.1 ^5.2 ^5.3 Gauss, A et al. (2013) Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases. Int J Med Sci 10 1259-70 PubMed GONUTS page

[PMID:21696602-6] 6.0 ^6.1 ^6.2 ^6.3 Affentranger, S et al. (2011) Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes. BMC Cell Biol. 12 28 PubMed GONUTS page

[PMID:24046456-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Guillaume, E et al. (2013) Flotillin microdomains stabilize cadherins at cell-cell junctions. J. Cell. Sci. 126 5293-304 PubMed GONUTS page

[PMID:25893292-8] Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page

[PMID:25204797-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page

[PMID:21423176-10] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:23533145-11] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-12] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-13] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-14] 14.0 ^14.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21119006-15] Cornfine, S et al. (2011) The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Mol. Biol. Cell 22 202-15 PubMed GONUTS page

[PMID:15469992-16] Bared, SM et al. (2004) Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Mol. Biol. Cell 15 5399-407 PubMed GONUTS page

[PMID:18000879-17] 17.0 ^17.1 Oeffner, F et al. (2008) Novel interaction partners of Bardet-Biedl syndrome proteins. Cell Motil. Cytoskeleton 65 143-55 PubMed GONUTS page

[PMID:24612608-18] 18.0 ^18.1 John, BA et al. (2014) Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting. FEBS J. 281 2074-87 PubMed GONUTS page

[PMID:18850735-19] Fang, L et al. (2008) Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J. Proteome Res. 7 4914-25 PubMed GONUTS page

[PMID:20682791-20] Gorbea, C et al. (2010) A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J. Biol. Chem. 285 31616-33 PubMed GONUTS page

[PMID:17897319-21] Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page

[PMID:9153235-22] 22.0 ^22.1 Bickel, PE et al. (1997) Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem. 272 13793-802 PubMed GONUTS page

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