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HUMAN:PEPA5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PGA5
Protein Name(s) Pepsin A-5

Pepsinogen-5

External Links
UniProt P0DJD9
EMBL M26032
M26025
M26026
M26027
M26028
M26029
M26030
M26031
AP003037
CH471076
BC029055
BC146999
BC171889
CCDS CCDS8001.1
PIR A00980
A30142
A92058
B30142
RefSeq NP_055039.1
UniGene Hs.432854
ProteinModelPortal P0DJD9
SMR P0DJD9
BindingDB P0DJD9
ChEMBL CHEMBL3295
MEROPS A01.071
PhosphoSite P0DJD9
DMDM 378522017
PRIDE P0DJD9
Ensembl ENST00000312403
GeneID 5222
KEGG hsa:5222
UCSC uc001nqz.3
CTD 5222
GeneCards GC11P061008
HGNC HGNC:8887
HPA CAB026358
HPA046875
MIM 169700
169730
neXtProt NX_P0DJD9
PharmGKB PA33224
GeneTree ENSGT00760000118929
InParanoid P0DJD9
KO K06002
OMA FQGMNIP
OrthoDB EOG7HQN88
PhylomeDB P0DJD9
TreeFam TF314990
GeneWiki PGA5
GenomeRNAi 5222
NextBio 20188
PRO PR:P0DJD9
Proteomes UP000005640
Bgee P0DJD9
CleanEx HS_PGA5
ExpressionAtlas P0DJD9
GO GO:0070062
GO:0004190
GO:0007586
Gene3D 2.40.70.10
InterPro IPR001461
IPR001969
IPR012848
IPR021109
PANTHER PTHR13683
Pfam PF07966
PF00026
PRINTS PR00792
SUPFAM SSF50630
PROSITE PS00141

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006508

proteolysis

other:PMC1712889

ECO:0000314

P

he techniques of starch gel electrophoresis, immunoelectrophoresis and high resolutiongelfiltrationhavebeenusedtoinvestigatethepepticcleavageofhuman G-myeloma proteins of the four known subclasses.

complete
CACAO 9364

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030163

protein catabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201569
PANTHER:PTN000342793
UniProtKB:P0CY27
UniProtKB:Q5A8N2
UniProtKB:Q5AC08

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000190503
CGD:CAL0000194661
CGD:CAL0000196689
CGD:CAL0000201140
MGI:MGI:1346542
PANTHER:PTN000342793
RGD:621511
SGD:S000002551
TAIR:locus:2008940
UniProtKB:P00797
UniProtKB:P0CY27
UniProtKB:P41748
UniProtKB:P43094
UniProtKB:P56817
UniProtKB:Q59VH7
UniProtKB:Q5AC08
UniProtKB:Q8I6Z5
WB:WBGene00000217

P

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000196689
MGI:MGI:107361
MGI:MGI:1915935
MGI:MGI:88562
PANTHER:PTN000342793
PomBase:SPCC1795.09
RGD:2446
SGD:S000001277
SGD:S000002551
SGD:S000004110
SGD:S000004111
TAIR:locus:2145954
UniProtKB:P00797
UniProtKB:P0CY27
UniProtKB:P14091
UniProtKB:P20142
UniProtKB:P56817
UniProtKB:Q4WNV0
UniProtKB:Q5AC08
UniProtKB:Q8I6Z5
UniProtKB:Q9LTW4
UniProtKB:Q9Y5Z0

F

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR012848

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR012848

P

Seeded From UniProt

complete

part_of

GO:0097486

multivesicular body lumen

Reactome:R-HSA-5685902
Reactome:R-HSA-5684864

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

involved_in

GO:0007586

digestion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0222

P

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0064

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page