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HUMAN:PROC

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PROC
Protein Name(s) Vitamin K-dependent protein C

Anticoagulant protein C Autoprothrombin IIA Blood coagulation factor XIV Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide

External Links
UniProt P04070
EMBL X02750
M11228
M12712
M12683
M12684
M12685
M12686
M12687
AF378903
AK298454
AC068282
CH471103
BC034377
S58668
K02059
S76088
S76090
CCDS CCDS2145.1
PIR A22331
RefSeq NP_000303.1
XP_005263773.1
UniGene Hs.224698
PDB 1AUT
1LQV
1PCU
2PCT
3F6U
3JTC
4DT7
PDBsum 1AUT
1LQV
1PCU
2PCT
3F6U
3JTC
4DT7
ProteinModelPortal P04070
SMR P04070
BioGrid 111608
IntAct P04070
MINT MINT-8247437
STRING 9606.ENSP00000234071
BindingDB P04070
ChEMBL CHEMBL4444
DrugBank DB00025
DB00170
DB00464
MEROPS S01.218
PhosphoSite P04070
UniCarbKB P04070
DMDM 131067
MaxQB P04070
PaxDb P04070
PeptideAtlas P04070
PRIDE P04070
DNASU 5624
Ensembl ENST00000234071
GeneID 5624
KEGG hsa:5624
UCSC uc002tok.3
CTD 5624
GeneCards GC02P128176
HGNC HGNC:9451
HPA CAB016721
CAB016792
HPA005550
MIM 176860
612283
612304
neXtProt NX_P04070
Orphanet 745
PharmGKB PA33799
eggNOG COG5640
GeneTree ENSGT00760000118890
HOGENOM HOG000251821
HOVERGEN HBG013304
InParanoid P04070
KO K01344
OMA PNYSKST
PhylomeDB P04070
TreeFam TF327329
Reactome REACT_1050
REACT_12051
REACT_1439
REACT_1906
REACT_326
REACT_733
EvolutionaryTrace P04070
GeneWiki Protein_C
GenomeRNAi 5624
NextBio 21860
PMAP-CutDB P04070
PRO PR:P04070
Proteomes UP000005640
Bgee P04070
CleanEx HS_PROC
ExpressionAtlas P04070
Genevestigator P04070
GO GO:0005788
GO:0005576
GO:0005796
GO:0005886
GO:0005509
GO:0004252
GO:0007596
GO:0044267
GO:0050900
GO:0043066
GO:0030195
GO:0017187
GO:0043687
GO:0006508
Gene3D 4.10.740.10
InterPro IPR017857
IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR000294
IPR012224
IPR001254
IPR018114
IPR001314
IPR009003
Pfam PF00594
PF00089
PIRSF PIRSF001143
PRINTS PR00722
PR00001
SMART SM00181
SM00179
SM00069
SM00020
SUPFAM SSF50494
SSF57630
PROSITE PS00010
PS00022
PS01186
PS50026
PS01187
PS00011
PS50998
PS50240
PS00134
PS00135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004252

serine-type endopeptidase activity

PMID:25748729[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0030195

negative regulation of blood coagulation

PMID:9529319[2]

ECO:0000304

P

EPCR enables significant levels of protein C activation. These results suggest that the protein C anticoagulation pathway is important for the regulation of blood coagulation not only in microvessels but also in large vessels.

complete
CACAO 9365

part_of

GO:0005783

endoplasmic reticulum

PMID:25748729[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:25748729[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903142

positive regulation of establishment of endothelial barrier

PMID:25651845[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

PMID:25651845[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050819

negative regulation of coagulation

PMID:25651845[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:12563316[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:12052963[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[6]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030195

negative regulation of blood coagulation

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97771
PANTHER:PTN000669132
RGD:3411

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000669108
RGD:3411
RGD:628678
UniProtKB:P00740

C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000669132
UniProtKB:P04070

F

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR012224
InterPro:IPR018114

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000294
InterPro:IPR001881
InterPro:IPR012224
InterPro:IPR018097
InterPro:IPR035972

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000294
InterPro:IPR035972

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012224

P

Seeded From UniProt

complete

involved_in

GO:0030195

negative regulation of blood coagulation

PMID:15005336[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:15005336[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

Reactome:R-HSA-140875

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

Reactome:R-HSA-159763

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-159771
Reactome:R-HSA-159762

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8952289
Reactome:R-HSA-159795
Reactome:R-HSA-159762

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-5607058
Reactome:R-HSA-5607002
Reactome:R-HSA-5606996
Reactome:R-HSA-5604929
Reactome:R-HSA-5603467
Reactome:R-HSA-5591086
Reactome:R-HSA-5591052
Reactome:R-HSA-5591040
Reactome:R-HSA-141040
Reactome:R-HSA-141026

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0007599

hemostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0356

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0094

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Liu, H et al. (2015) Compound heterozygous protein C deficiency in a family with venous thrombosis: Identification and in vitro study of p.Asp297His and p.Val420Leu mutations. Gene 563 35-40 PubMed GONUTS page
  2. ↑ Fukudome, K et al. (1998) Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J. Exp. Med. 187 1029-35 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Ding, Q et al. (2015) Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays. Blood 125 2428-34 PubMed GONUTS page
  4. ↑ Cheng, T et al. (2003) Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat. Med. 9 338-42 PubMed GONUTS page
  5. ↑ Riewald, M et al. (2002) Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296 1880-2 PubMed GONUTS page
  6. ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ 8.0 8.1 Dahlbäck, B (2004) Progress in the understanding of the protein C anticoagulant pathway. Int. J. Hematol. 79 109-16 PubMed GONUTS page
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