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PMID:3815101
| Citation |
Fung, SJ, Reddy, VK, Bowker, RM and Barnes, CD (1987) Differential labeling of the vestibular complex following unilateral injections of horseradish peroxidase into the cat and rat locus coeruleus. Brain Res. 401:347-52 |
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| Abstract |
Following unilateral injections of horseradish peroxidase into the cat and rat locus coeruleus (LC), bilateral retrograde labeling was evident in all 4 vestibular nuclei. In both species, the major contributions of LC afferents arose from the ipsilateral rather than the contralateral vestibular nuclei. Quantitative analysis in the rat has indicated that approximately 90% of the total vestibular-LC projections originated from the ipsilateral vestibular nuclear complex, with 10% from the contralateral. The frequency distribution was in the order of lateral greater than medial greater than superior greater than inferior vestibular nuclei. |
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| Keywords |
Animals; Cats; Locus Coeruleus/anatomy & histology; Neural Pathways/physiology; Rats; Rats, Inbred Strains; Species Specificity; Vestibular Nuclei/anatomy & histology; Vestibular Nucleus, Lateral/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0045806: negative regulation of endocytosis |
ECO:0000315: |
P |
Figure 2B. Fluorescent staining of APP-deficient neurons reveals increased levels of internalized p75NTR. The control group (with higher levels of APP)showed decreased levels of internalized p75NTR. |
complete | ||||
| GO:0009986: cell surface |
ECO:0000314: |
C |
Figure 1A. Western blotting reveals the presence of p75NTR on cell surfaces. |
complete | ||||
| GO:0045773: positive regulation of axon extension |
ECO:0000315: |
P |
Figure 2b. APP deficient neurons lead to decreased cell surface levels of p75NTR, and Figure 3A. shows that the decreased cell surface levels of p75NTR in APP deficient cells significantly decrease neurite outgrowth relative to control cells. |
complete | ||||
| GO:0009986: cell surface |
ECO:0000314: |
C |
Figure 1A. Western blotting displays that NTRK1 (TrkA) was present on cell surfaces. |
complete | ||||
See also
References
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