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HUMAN:SHBG
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SHBG | |
| Protein Name(s) | Sex hormone-binding globulin
SHBG Sex steroid-binding protein SBP Testis-specific androgen-binding protein ABP Testosterone-estradiol-binding globulin TeBG Testosterone-estrogen-binding globulin | |
| External Links | ||
| UniProt | P04278 | |
| EMBL | X16349 X16350 X16351 M31651 CD013955 BC069597 BC101785 BC112186 AC007421 X05403 EU352661 X05885 X05792 | |
| CCDS | CCDS11117.1 CCDS54082.1 CCDS54083.1 CCDS58513.1 | |
| PIR | S09606 | |
| RefSeq | NP_001031.2 NP_001139751.1 NP_001139752.1 NP_001139753.1 NP_001276042.1 NP_001276043.1 NP_001276044.1 NP_001276045.1 | |
| UniGene | Hs.632235 | |
| PDB | 1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW | |
| PDBsum | 1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW | |
| ProteinModelPortal | P04278 | |
| SMR | P04278 | |
| BioGrid | 112359 | |
| IntAct | P04278 | |
| STRING | 9606.ENSP00000369816 | |
| BindingDB | P04278 | |
| ChEMBL | CHEMBL3305 | |
| DrugBank | DB01406 DB00858 DB00783 DB04574 DB01185 DB00741 DB06710 DB00648 DB00717 DB00421 DB00624 DB05275 | |
| UniCarbKB | P04278 | |
| DMDM | 134907 | |
| PaxDb | P04278 | |
| PeptideAtlas | P04278 | |
| PRIDE | P04278 | |
| DNASU | 6462 | |
| Ensembl | ENST00000380450 ENST00000416273 ENST00000441599 ENST00000575903 ENST00000576830 | |
| GeneID | 6462 | |
| KEGG | hsa:6462 | |
| UCSC | uc002gie.2 | |
| CTD | 6462 | |
| GeneCards | GC17P007523 | |
| HGNC | HGNC:10839 | |
| MIM | 182205 | |
| neXtProt | NX_P04278 | |
| PharmGKB | PA35745 | |
| eggNOG | NOG39525 | |
| GeneTree | ENSGT00530000063339 | |
| HOGENOM | HOG000285982 | |
| HOVERGEN | HBG017800 | |
| InParanoid | P04278 | |
| OMA | EIQLHNH | |
| PhylomeDB | P04278 | |
| TreeFam | TF334367 | |
| ChiTaRS | SHBG | |
| EvolutionaryTrace | P04278 | |
| GeneWiki | Sex_hormone-binding_globulin | |
| GenomeRNAi | 6462 | |
| NextBio | 25109 | |
| PRO | PR:P04278 | |
| Proteomes | UP000005640 | |
| Bgee | P04278 | |
| CleanEx | HS_SHBG | |
| ExpressionAtlas | P04278 | |
| Genevestigator | P04278 | |
| GO | GO:0005576 GO:0070062 GO:0005497 GO:0007285 | |
| Gene3D | 2.60.120.200 | |
| InterPro | IPR013320 IPR001791 | |
| Pfam | PF00054 | |
| SMART | SM00282 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS50025 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0007285 |
ECO:0000247 |
|
Analysis of Paper. See Figure 1. Gel Electrophoresis |
complete | ||||||
| GO:0007285 |
primary spermatocyte growth |
ECO:0000255 |
P |
See Figure 2. It shows the amino acid sequence of SHBG gotten from the sequence of its cDNA. |
complete | |||||
| GO:0007285 |
primary spermatocyte growth |
ECO:0000255 |
|
P |
Analysis of Paper. See Figure 1(b). Shows the Amino acid sequences determined by peptides. Those generated from SHBG are underlined |
complete | ||||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0007285 |
primary spermatocyte growth |
ECO:0000255 |
|
P |
Analysis of Paper. See Figure 2. Shows images of the human SHBG steroid-binding site |
complete | ||||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0007285 |
primary spermatocyte growth |
ECO:0000247 |
|
P |
Analysis from article. See Figure 4. Shows the multiple sequence alignment of the G domain which is part of he SHBG family |
complete | ||||
|
enables |
GO:0005497 |
androgen binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005496 |
steroid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Gershagen, S et al. (1989) Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. Nucleic Acids Res. 17 9245-58 PubMed GONUTS page
- ↑ 2.0 2.1 Hammond, GL et al. (1987) The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain. FEBS Lett. 215 100-4 PubMed GONUTS page
- ↑ 3.0 3.1 Gershagen, S et al. (1987) A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S. FEBS Lett. 220 129-35 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 5.0 5.1 Grishkovskaya, I et al. (2002) Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation. J. Biol. Chem. 277 32086-93 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ 7.0 7.1 Grishkovskaya, I et al. (2000) Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain. EMBO J. 19 504-12 PubMed GONUTS page
