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RAT:ASIC2
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Asic2 (synonyms: Accn1, Bnac1, Mdeg) | |
| Protein Name(s) | Acid-sensing ion channel 2
ASIC2 Amiloride-sensitive brain sodium channel Amiloride-sensitive brain sodium channel 2 Amiloride-sensitive cation channel 1, neuronal Amiloride-sensitive cation channel neuronal 1 Brain sodium channel 1 BNC1 BNaC1 Mammalian degenerin homolog MDEG | |
| External Links | ||
| UniProt | Q62962 | |
| EMBL | U53211 Y14635 | |
| RefSeq | NP_001029186.1 NP_037024.2 | |
| UniGene | Rn.37523 | |
| ProteinModelPortal | Q62962 | |
| SMR | Q62962 | |
| DIP | DIP-41193N | |
| MINT | MINT-223656 | |
| GuidetoPHARMACOLOGY | 685 | |
| TCDB | 1.A.6.1.2 | |
| PhosphoSite | Q62962 | |
| PaxDb | Q62962 | |
| Ensembl | ENSRNOT00000009348 | |
| GeneID | 25364 | |
| KEGG | rno:25364 | |
| CTD | 40 | |
| RGD | 2017 | |
| eggNOG | NOG262945 | |
| GeneTree | ENSGT00760000119120 | |
| HOGENOM | HOG000247010 | |
| HOVERGEN | HBG004150 | |
| InParanoid | Q62962 | |
| KO | K04828 | |
| OMA | HMCAGRA | |
| OrthoDB | EOG72VH5P | |
| PhylomeDB | Q62962 | |
| TreeFam | TF330663 | |
| Reactome | REACT_198302 | |
| NextBio | 606355 | |
| PRO | PR:Q62962 | |
| Proteomes | UP000002494 | |
| Genevestigator | Q62962 | |
| GO | GO:0043197 GO:0005887 GO:0043025 GO:0045202 GO:0005216 GO:0022839 GO:0015280 GO:0005248 GO:0071468 GO:0035690 GO:0050974 GO:0043066 GO:0007602 GO:2001259 GO:0051965 GO:0035418 GO:0030193 GO:0010468 GO:0042391 GO:0003026 GO:0019229 GO:0007605 GO:0050915 GO:0035725 GO:0006814 | |
| InterPro | IPR004724 IPR001873 IPR020903 | |
| PANTHER | PTHR11690 | |
| Pfam | PF00858 | |
| PRINTS | PR01078 | |
| TIGRFAMs | TIGR00859 | |
| PROSITE | PS01206 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2001259 |
positive regulation of cation channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071468 |
cellular response to acidic pH |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006814 |
sodium ion transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005248 |
voltage-gated sodium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005216 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035725 |
sodium ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005272 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035725 |
sodium ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0015280 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035725 |
sodium ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005248 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035725 |
sodium ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005272 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005272 |
sodium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006814 |
sodium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015280 |
ligand-gated sodium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006814 |
sodium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005272 |
sodium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0005261 |
cation channel activity |
ECO:0000266 |
F |
Figure 1 shows the deduced protein sequence of MDEG and comparison other members of this ion channel family. |
Missing: with/from | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Ugawa, S et al. (2003) Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel. J. Neurosci. 23 3616-22 PubMed GONUTS page
- ↑ 2.0 2.1 Lingueglia, E et al. (1997) A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J. Biol. Chem. 272 29778-83 PubMed GONUTS page
- ↑ Deval, E et al. (2004) ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. J. Biol. Chem. 279 19531-9 PubMed GONUTS page
- ↑ Waldmann, R et al. (1996) The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J. Biol. Chem. 271 10433-6 PubMed GONUTS page
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