DROME:EGFR

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Egfr (synonyms: c-erbB, DER, top)
Protein Name(s)	Epidermal growth factor receptor Egfr Drosophila relative of ERBB Gurken receptor Protein torpedo
External Links
UniProt	P04412
EMBL	AF052754 AF052753 AF052754 AF052752 K03054 K03417 K03416 AF109077 AF109078 AF109082 AF109078 AF109084 AF109079 AF109081 AF109079 AF109083 AF109080 AE013599 X02293 AJ002912 X78920 X78918 X78919
PIR	A00640
RefSeq	NP_476759.1
PDB	3I2T 3LTF 3LTG
PDBsum	3I2T 3LTF 3LTG
ProteinModelPortal	P04412
SMR	P04412
BioGrid	63083
DIP	DIP-17316N
IntAct	P04412
MINT	MINT-806082
PaxDb	P04412
GeneID	37455
KEGG	dme:Dmel_CG10079
CTD	1956
FlyBase	FBgn0003731
eggNOG	COG0515
InParanoid	P04412
KO	K04361
OrthoDB	EOG7SV0TH
PhylomeDB	P04412
BRENDA	2.7.10.1
Reactome	REACT_180799 REACT_181313 REACT_181975 REACT_182055 REACT_184384 REACT_202927 REACT_203905 REACT_210116 REACT_212353 REACT_212366 REACT_214005 REACT_214264 REACT_217475 REACT_217656 REACT_233569 REACT_234406 REACT_240291 REACT_250163 REACT_262116 REACT_263006
SignaLink	P04412
ChiTaRS	Egfr
EvolutionaryTrace	P04412
GenomeRNAi	37455
NextBio	803734
Proteomes	UP000000803
Bgee	P04412
ExpressionAtlas	P04412
GO	GO:0016021 GO:0005886 GO:0005524 GO:0005006 GO:0004713 GO:0004888 GO:0007469 GO:0009952 GO:0048149 GO:0007350 GO:0007298 GO:0007420 GO:0046845 GO:0045165 GO:0001709 GO:0030031 GO:0030381 GO:0042676 GO:0048749 GO:0001745 GO:0001751 GO:0001752 GO:0035225 GO:0048546 GO:0046843 GO:0007391 GO:0009953 GO:0000578 GO:0009880 GO:0007173 GO:0061331 GO:0035088 GO:0001654 GO:0007455 GO:0048139 GO:0000086 GO:0007369 GO:0007390 GO:0030718 GO:0008406 GO:0007482 GO:0003015 GO:0007444 GO:0007447 GO:0007476 GO:0008586 GO:0007474 GO:0007479 GO:0035160 GO:0048140 GO:0007443 GO:0008071 GO:0002009 GO:0016333 GO:0016203 GO:0042694 GO:0043066 GO:2001234 GO:0046673 GO:2000134 GO:0022008 GO:0035310 GO:0007477 GO:0001742 GO:0008355 GO:0016318 GO:0007314 GO:0007309 GO:0007310 GO:0048477 GO:0007424 GO:0018108 GO:0007422 GO:0008284 GO:0090303 GO:0007458 GO:0006468 GO:0045466 GO:0045610 GO:0007346 GO:0045468 GO:0007431 GO:0016330 GO:0007367 GO:0016337 GO:0035277 GO:0048865 GO:0007421 GO:0035202 GO:0035309 GO:0007472 GO:0007473
Gene3D	3.80.20.20
InterPro	IPR006211 IPR006212 IPR009030 IPR011009 IPR000719 IPR017441 IPR000494 IPR001245 IPR008266 IPR020635
Pfam	PF00757 PF07714 PF01030
PRINTS	PR00109
SMART	SM00261 SM00219
SUPFAM	SSF56112 SSF57184
PROSITE	PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010629	negative regulation of gene expression	PMID:28628612^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q7K5M0) occurs_in:(UBERON:0000924) happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:28628612^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P42003) occurs_in:(UBERON:0000924) happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28628612^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P07713) occurs_in:(UBERON:0000924) happens_during:(GO:0009790)	Seeded From UniProt	complete
	GO:0005006	epidermal growth factor receptor activity	PMID:21340027^[2]	ECO:0000315			F		Figure 1. (A and A') The EGFR activity is correlated with the morphology of dorsal appendages. Two dorsal appendages indicate normal activity of EGFR (wt). (B and B') Two dorsal appendages fused at the base indicate low level of EGFR activity (V1), whereas (C and C') one fused dorsal appendage indicates a even lower level of EGFR activity (V2). (D and D') No appendage indicates the lowest level of EGFR activity (V3).	complete
involved_in	GO:0007395	dorsal closure, spreading of leading edge cells	PMID:28628612^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:28628612^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:8070664^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000698827 RGD:2561	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003731 MGI:MGI:104771 MGI:MGI:95294 PANTHER:PTN000698827 RGD:2543 RGD:2561 RGD:620486 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:Q15303	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
involved_in	GO:0043703	photoreceptor cell fate determination	PMID:7833286^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005006	epidermal growth factor-activated receptor activity	PMID:7601354^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0007173)	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:7601354^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007298	border follicle cell migration	PMID:23525006^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0040068	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10089881^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:10089881^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16326394^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007426	tracheal outgrowth, open tracheal system	PMID:16326394^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:10688656^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005006	epidermal growth factor-activated receptor activity	PMID:10688656^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(FB:FBgn0005672) part_of:(GO:0007173)	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:22242005^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042675	compound eye cone cell differentiation	PMID:8929534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043703	photoreceptor cell fate determination	PMID:8929534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007474	imaginal disc-derived wing vein specification	PMID:10331978^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007479	leg disc proximal/distal pattern formation	PMID:15965980^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005006	epidermal growth factor-activated receptor activity	PMID:11782411^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(FB:FBgn0001137)	Seeded From UniProt	complete
involved_in	GO:0046530	photoreceptor cell differentiation	PMID:11245584^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:11245584^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045572	positive regulation of imaginal disc growth	PMID:29719260^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:8978043^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003205	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:8565833^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005006	epidermal growth factor-activated receptor activity	PMID:7651519^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(FB:FBgn0005672) part_of:(GO:0007173)	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:7651519^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:8162856^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003256	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:10652272^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:9729495^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:9531530^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005006	epidermal growth factor-activated receptor activity	PMID:9531530^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(FB:FBgn0003984) part_of:(GO:0007173)	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:9531530^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001742	oenocyte differentiation	PMID:28715417^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:21516106^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19317464^[27]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007474	imaginal disc-derived wing vein specification	PMID:23549788^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:23579691^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:23579691^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008355	olfactory learning	PMID:23512935^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	PMID:22140578^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008406	gonad development	PMID:21377458^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0035230	cytoneme	PMID:21493861^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048546	digestive tract morphogenesis	PMID:21176204^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21176204^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003015	heart process	PMID:20523889^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048865	stem cell fate commitment	PMID:20463031^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	PMID:19464045^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:19141677^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	PMID:17898168^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0262656	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:17898168^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0262656	P		Seeded From UniProt	complete
involved_in	GO:0007482	haltere development	PMID:16815386^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007476	imaginal disc-derived wing morphogenesis	PMID:16648592^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903688	positive regulation of border follicle cell migration	PMID:16712835^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0032006	P		Seeded From UniProt	complete
involved_in	GO:0035088	establishment or maintenance of apical/basal cell polarity	PMID:16908845^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007309	oocyte axis specification	PMID:16908845^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17055987^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046843	dorsal appendage formation	PMID:17008069^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035160	maintenance of epithelial integrity, open tracheal system	PMID:16831830^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:16831830^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007455	eye-antennal disc morphogenesis	PMID:16963016^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030718	germ-line stem cell population maintenance	PMID:16399083^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0265778	P		Seeded From UniProt	complete
involved_in	GO:0001751	compound eye photoreceptor cell differentiation	PMID:16377567^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007367	segment polarity determination	PMID:15930099^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035277	spiracle morphogenesis, open tracheal system	PMID:15930099^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903688	positive regulation of border follicle cell migration	PMID:16054027^[51]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0032006	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:16054027^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903688	positive regulation of border follicle cell migration	PMID:16054027^[51]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020224	P		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PMID:15809036^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035225	determination of genital disc primordium	PMID:15893978^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008586	imaginal disc-derived wing vein morphogenesis	PMID:15766758^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046673	negative regulation of compound eye retinal cell programmed cell death	PMID:15511643^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016318	ommatidial rotation	PMID:14507782^[56]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016318	ommatidial rotation	PMID:14507785^[57]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:14536058^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007476	imaginal disc-derived wing morphogenesis	PMID:14536058^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007422	peripheral nervous system development	PMID:12967983^[59]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007476	imaginal disc-derived wing morphogenesis	PMID:12930782^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007472	wing disc morphogenesis	PMID:12930782^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030031	cell projection assembly	PMID:12198500^[61]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007479	leg disc proximal/distal pattern formation	PMID:12181568^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061331	epithelial cell proliferation involved in Malpighian tubule morphogenesis	PMID:11861476^[63]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030381	chorion-containing eggshell pattern formation	PMID:11606538^[64]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003205	P		Seeded From UniProt	complete
involved_in	GO:0048749	compound eye development	PMID:11301250^[65]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016330	second mitotic wave involved in compound eye morphogenesis	PMID:11257224^[66]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007298	border follicle cell migration	PMID:11141565^[67]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007476	imaginal disc-derived wing morphogenesis	PMID:10995384^[68]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007477	notum development	PMID:10995384^[68]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035310	notum cell fate specification	PMID:10995384^[68]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007444	imaginal disc development	PMID:10934021^[69]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035309	wing and notum subfield formation	PMID:10860999^[70]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002009	morphogenesis of an epithelium	PMID:9927461^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007443	Malpighian tubule morphogenesis	PMID:9927461^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007390	germ-band shortening	PMID:9927461^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007431	salivary gland development	PMID:9927461^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:9927461^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:9814703^[72]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0011706	P		Seeded From UniProt	complete
involved_in	GO:0061331	epithelial cell proliferation involved in Malpighian tubule morphogenesis	PMID:9637680^[73]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016333	morphogenesis of follicular epithelium	PMID:9504923^[74]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:16326394^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007426)	Seeded From UniProt	complete
involved_in	GO:0007390	germ-band shortening	PMID:8946251^[75]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	PMID:16326394^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048749	compound eye development	PMID:1634999^[76]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008071	maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded	PMID:3107840^[77]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016245 InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006211	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR006211 InterPro:IPR016245 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR006211 InterPro:IPR008266 InterPro:IPR016245 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006211 InterPro:IPR016245	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006211	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016245	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19718021^[78]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04412-1	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
	GO:0004872	receptor activity	PMID:22574233^[79]	ECO:0000314			F		Figure 2 shows that the EGFR ligand activates the RAS-RAF-MEK and P13K-AKT-mTOR pathways that leads to cell survival and cancer cell proliferation.	complete CACAO 9405
	GO:0009792	embryo development ending in birth or egg hatching	PMID:8070664^[3]	ECO:0000315			P		Table 2. Molecular alterations associated with torpedo mutations.	complete CACAO 3412
	GO:0004872	receptor activity	PMID:22574233^[79]	ECO:0000314			F		Figure 2 shows that the EGFR ligand activates the RAS-RAF-MEK and P13K-AKT-mTOR pathways that ultimately leads to cancer cell survival and proliferation.	complete CACAO 9408
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Kushnir, T et al. (2017) Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure. PLoS Genet. 13 e1006860 PubMed GONUTS page
↑ Wang, PY & Pai, LM (2011) D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoS ONE 6 e17097 PubMed GONUTS page
↑ ^3.0 ^3.1 Clifford, R & Schüpbach, T (1994) Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein. Genetics 137 531-50 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Freeman, M (1994) The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech. Dev. 48 25-33 PubMed GONUTS page
↑ ^6.0 ^6.1 Schweitzer, R et al. (1995) Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9 1518-29 PubMed GONUTS page
↑ Fernández-Espartero, CH et al. (2013) GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation. J. Cell. Sci. 126 2285-93 PubMed GONUTS page
↑ ^8.0 ^8.1 Casci, T et al. (1999) Sprouty, an intracellular inhibitor of Ras signaling. Cell 96 655-65 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Cabernard, C & Affolter, M (2005) Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev. Cell 9 831-42 PubMed GONUTS page
↑ ^10.0 ^10.1 Jin, MH et al. (2000) The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor. Mol. Cell. Biol. 20 2098-107 PubMed GONUTS page
↑ Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page
↑ ^12.0 ^12.1 Freeman, M (1996) Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87 651-60 PubMed GONUTS page
↑ Guichard, A et al. (1999) rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development 126 2663-76 PubMed GONUTS page
↑ Galindo, MI et al. (2005) Dynamic EGFR-Ras signalling in Drosophila leg development. Dev. Dyn. 233 1496-508 PubMed GONUTS page
↑ Ghiglione, C et al. (2002) Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development 129 175-86 PubMed GONUTS page
↑ ^16.0 ^16.1 Yang, L & Baker, NE (2001) Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina. Development 128 1183-91 PubMed GONUTS page
↑ Gerlach, SU et al. (2018) Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure. Cell Rep 23 1491-1503 PubMed GONUTS page
↑ Schnorr, JD & Berg, CA (1996) Differential activity of Ras1 during patterning of the Drosophila dorsoventral axis. Genetics 144 1545-57 PubMed GONUTS page
↑ Golembo, M et al. (1996) Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122 223-30 PubMed GONUTS page
↑ ^20.0 ^20.1 Schweitzer, R et al. (1995) Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376 699-702 PubMed GONUTS page
↑ Diaz-Benjumea, FJ & Hafen, E (1994) The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120 569-78 PubMed GONUTS page
↑ Bang, AG & Kintner, C (2000) Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz. Genes Dev. 14 177-86 PubMed GONUTS page
↑ Kumar, JP et al. (1998) Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125 3875-85 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Schnepp, B et al. (1998) EGF domain swap converts a drosophila EGF receptor activator into an inhibitor. Genes Dev. 12 908-13 PubMed GONUTS page
↑ Wang, G et al. (2017) A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes. PLoS Genet. 13 e1006910 PubMed GONUTS page
↑ Kamakura, M (2011) Royalactin induces queen differentiation in honeybees. Nature 473 478-83 PubMed GONUTS page
↑ Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
↑ Hahn, I et al. (2013) The Drosophila Arf GEF Steppke controls MAPK activation in EGFR signaling. J. Cell. Sci. 126 2470-9 PubMed GONUTS page
↑ ^29.0 ^29.1 Shen, W et al. (2013) Modulation of morphogenesis by Egfr during dorsal closure in Drosophila. PLoS ONE 8 e60180 PubMed GONUTS page
↑ Rahn, T et al. (2013) EGFR signaling in the brain is necessary for olfactory learning in Drosophila larvae. Learn. Mem. 20 194-200 PubMed GONUTS page
↑ Geiger, JA et al. (2011) Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila. PLoS ONE 6 e28349 PubMed GONUTS page
↑ Weyers, JJ et al. (2011) A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev. Biol. 353 217-28 PubMed GONUTS page
↑ Roy, S et al. (2011) Specificity of Drosophila cytonemes for distinct signaling pathways. Science 332 354-8 PubMed GONUTS page
↑ ^34.0 ^34.1 Buchon, N et al. (2010) Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 8 152 PubMed GONUTS page
↑ Yu, L et al. (2010) Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. PLoS Genet. 6 e1000969 PubMed GONUTS page
↑ Figeac, N et al. (2010) Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway. Development 137 1965-73 PubMed GONUTS page
↑ Corl, AB et al. (2009) Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell 137 949-60 PubMed GONUTS page
↑ Jiang, H & Edgar, BA (2009) EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136 483-93 PubMed GONUTS page
↑ ^39.0 ^39.1 Orian, A et al. (2007) A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc. Natl. Acad. Sci. U.S.A. 104 15771-6 PubMed GONUTS page
↑ Pallavi, SK et al. (2006) Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev. Biol. 296 340-52 PubMed GONUTS page
↑ Dworkin, I & Gibson, G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173 1417-31 PubMed GONUTS page
↑ McDonald, JA et al. (2006) Multiple EGFR ligands participate in guiding migrating border cells. Dev. Biol. 296 94-103 PubMed GONUTS page
↑ ^43.0 ^43.1 Poulton, JS & Deng, WM (2006) Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc. Natl. Acad. Sci. U.S.A. 103 12775-80 PubMed GONUTS page
↑ Parker, J (2006) Control of compartment size by an EGF ligand from neighboring cells. Curr. Biol. 16 2058-65 PubMed GONUTS page
↑ Wahlström, G et al. (2006) Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Mech. Dev. 123 801-18 PubMed GONUTS page
↑ ^46.0 ^46.1 Cela, C & Llimargas, M (2006) Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila. Development 133 3115-25 PubMed GONUTS page
↑ Brown, KE et al. (2006) Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway. Dev. Biol. 300 710-21 PubMed GONUTS page
↑ Wang, H et al. (2006) Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev. Cell 10 117-26 PubMed GONUTS page
↑ Li, X & Carthew, RW (2005) A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell 123 1267-77 PubMed GONUTS page
↑ ^50.0 ^50.1 Merabet, S et al. (2005) Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development 132 3093-102 PubMed GONUTS page
↑ ^51.0 ^51.1 ^51.2 Jékely, G et al. (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9 197-207 PubMed GONUTS page
↑ Firth, LC & Baker, NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8 541-51 PubMed GONUTS page
↑ Chen, EH et al. (2005) Allocation and specification of the genital disc precursor cells in Drosophila. Dev. Biol. 281 270-85 PubMed GONUTS page
↑ Ralston, A & Blair, SS (2005) Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev. Biol. 280 187-200 PubMed GONUTS page
↑ Cordero, J et al. (2004) A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye. Mech. Dev. 121 1523-30 PubMed GONUTS page
↑ Gaengel, K & Mlodzik, M (2003) Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. Development 130 5413-23 PubMed GONUTS page
↑ Brown, KE & Freeman, M (2003) Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. Development 130 5401-12 PubMed GONUTS page
↑ ^58.0 ^58.1 Weber, U et al. (2003) Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev. Cell 5 559-70 PubMed GONUTS page
↑ Sepp, KJ & Auld, VJ (2003) Reciprocal interactions between neurons and glia are required for Drosophila peripheral nervous system development. J. Neurosci. 23 8221-30 PubMed GONUTS page
↑ ^60.0 ^60.1 Pallavi, SK & Shashidhara, LS (2003) Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development 130 4931-41 PubMed GONUTS page
↑ Fulga, TA & Rørth, P (2002) Invasive cell migration is initiated by guided growth of long cellular extensions. Nat. Cell Biol. 4 715-9 PubMed GONUTS page
↑ Campbell, G (2002) Distalization of the Drosophila leg by graded EGF-receptor activity. Nature 418 781-5 PubMed GONUTS page
↑ Sudarsan, V et al. (2002) A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila. Development 129 935-44 PubMed GONUTS page
↑ Schnorr, JD et al. (2001) Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis. Genetics 159 609-22 PubMed GONUTS page
↑ Baonza, A et al. (2001) A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye. Curr. Biol. 11 396-404 PubMed GONUTS page
↑ Baker, NE & Yu, SY (2001) The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell 104 699-708 PubMed GONUTS page
↑ Duchek, P & Rørth, P (2001) Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 291 131-3 PubMed GONUTS page
↑ ^68.0 ^68.1 ^68.2 Wang, SH et al. (2000) Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development. Genes Dev. 14 2271-6 PubMed GONUTS page
↑ Kubota, K et al. (2000) EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila. Development 127 3769-76 PubMed GONUTS page
↑ Baonza, A et al. (2000) DER signaling restricts the boundaries of the wing field during Drosophila development. Proc. Natl. Acad. Sci. U.S.A. 97 7331-5 PubMed GONUTS page
↑ ^71.0 ^71.1 ^71.2 ^71.3 ^71.4 Liu, X et al. (1999) Identification of genes controlling malpighian tubule and other epithelial morphogenesis in Drosophila melanogaster. Genetics 151 685-95 PubMed GONUTS page
↑ Kurada, P & White, K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95 319-29 PubMed GONUTS page
↑ Kerber, B et al. (1998) Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney. Genes Dev. 12 1781-6 PubMed GONUTS page
↑ Rotoli, D et al. (1998) hold up is required for establishment of oocyte positioning, follicle cell fate and egg polarity and cooperates with Egfr during Drosophila oogenesis. Genetics 148 767-73 PubMed GONUTS page
↑ Goldman-Levi, R et al. (1996) Cellular pathways acting along the germband and in the amnioserosa may participate in germband retraction of the Drosophila melanogaster embryo. Int. J. Dev. Biol. 40 1043-51 PubMed GONUTS page
↑ Baker, NE et al. (1992) Mutations on the second chromosome affecting the Drosophila eye. J. Neurogenet. 8 85-100 PubMed GONUTS page
↑ Schüpbach, T (1987) Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster. Cell 49 699-707 PubMed GONUTS page
↑ Alvarado, D et al. (2009) ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature 461 287-91 PubMed GONUTS page
↑ ^79.0 ^79.1 Armaghany, T et al. (2012) Genetic alterations in colorectal cancer. Gastrointest Cancer Res 5 19-27 PubMed GONUTS page

[PMID:28628612-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Kushnir, T et al. (2017) Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure. PLoS Genet. 13 e1006860 PubMed GONUTS page

[PMID:21340027-2] Wang, PY & Pai, LM (2011) D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoS ONE 6 e17097 PubMed GONUTS page

[PMID:8070664-3] 3.0 ^3.1 Clifford, R & Schüpbach, T (1994) Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein. Genetics 137 531-50 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7833286-5] Freeman, M (1994) The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech. Dev. 48 25-33 PubMed GONUTS page

[PMID:7601354-6] 6.0 ^6.1 Schweitzer, R et al. (1995) Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9 1518-29 PubMed GONUTS page

[PMID:23525006-7] Fernández-Espartero, CH et al. (2013) GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation. J. Cell. Sci. 126 2285-93 PubMed GONUTS page

[PMID:10089881-8] 8.0 ^8.1 Casci, T et al. (1999) Sprouty, an intracellular inhibitor of Ras signaling. Cell 96 655-65 PubMed GONUTS page

[PMID:16326394-9] 9.0 ^9.1 ^9.2 ^9.3 Cabernard, C & Affolter, M (2005) Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev. Cell 9 831-42 PubMed GONUTS page

[PMID:10688656-10] 10.0 ^10.1 Jin, MH et al. (2000) The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor. Mol. Cell. Biol. 20 2098-107 PubMed GONUTS page

[PMID:22242005-11] Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page

[PMID:8929534-12] 12.0 ^12.1 Freeman, M (1996) Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87 651-60 PubMed GONUTS page

[PMID:10331978-13] Guichard, A et al. (1999) rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development 126 2663-76 PubMed GONUTS page

[PMID:15965980-14] Galindo, MI et al. (2005) Dynamic EGFR-Ras signalling in Drosophila leg development. Dev. Dyn. 233 1496-508 PubMed GONUTS page

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DROME:EGFR

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