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PMID:22140578

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Citation

Geiger, JA, Carvalho, L, Campos, I, Santos, AC and Jacinto, A (2011) Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila. PLoS ONE 6:e28349

Abstract

Epithelia act as physical barriers protecting living organisms and their organs from the surrounding environment. Simple epithelial tissues have the capacity to efficiently repair wounds through a resealing mechanism. The known molecular mechanisms underlying this process appear to be conserved in both vertebrates and invertebrates, namely the involvement of the transcription factors Grainy head (Grh) and Fos. In Drosophila, Grh and Fos lead to the activation of wound response genes required for epithelial repair. ERK is upstream of this pathway and known to be one of the first kinases to be activated upon wounding. However, it is still unclear how ERK activation contributes to a proper wound response and which molecular mechanisms regulate its activation.

Links

PubMed PMC3226689 Online version:10.1371/journal.pone.0028349

Keywords

Actomyosin/metabolism; Alleles; Animals; Cell Nucleus/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/embryology; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/metabolism; Enzyme Activation; Epithelium/embryology; Epithelium/enzymology; Epithelium/pathology; Extracellular Signal-Regulated MAP Kinases/metabolism; Gene Expression Regulation; Gene Knockdown Techniques; Genes, Reporter/genetics; MAP Kinase Signaling System; Models, Biological; Mutation/genetics; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Phenotype; Protein Transport; RNA Interference; RNA, Messenger/genetics; RNA, Messenger/metabolism; Receptor, Epidermal Growth Factor/metabolism; Time Factors; Transcription, Genetic; Wound Healing/genetics; ras Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:ERKA

involved_in

GO:0090303: positive regulation of wound healing

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CD2B2

involved_in

GO:0022416: chaeta development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CD2B2

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:CD2B2

involved_in

GO:0048749: compound eye development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CD2B2

involved_in

GO:0090303: positive regulation of wound healing

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CD2B2

involved_in

GO:0035220: wing disc development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:EGFR

involved_in

GO:0090303: positive regulation of wound healing

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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