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PMID:11301250

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Citation

Baonza, A, Casci, T and Freeman, M (2001) A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye. Curr. Biol. 11:396-404

Abstract

The differentiation of regularly spaced structures within an epithelium is a common feature of developmental pattern formation. The regular spacing of ommatidia in the Drosophila eye imaginal disc provides a good model for this phenomenon. The correct spacing of ommatidia is a central event in establishing the precise hexagonal pattern of ommatidia in the Drosophila compound eye. The R8 photoreceptors are the founder cells of each of the ommatidia that comprise the adult eye and are specified by a bHLH transcription factor, Atonal.

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PubMed

Keywords

Animals; Basic Helix-Loop-Helix Transcription Factors; DNA-Binding Proteins/metabolism; Drosophila Proteins; Drosophila melanogaster; Enzyme Activation; Eye/growth & development; Eye/metabolism; Eye Proteins/metabolism; Gene Expression; Glycoproteins/metabolism; Helix-Loop-Helix Motifs; Insect Proteins/metabolism; Membrane Proteins/genetics; Mitogen-Activated Protein Kinases/metabolism; Nerve Tissue Proteins/metabolism; Photoreceptor Cells, Invertebrate/metabolism; Receptor, Epidermal Growth Factor/genetics; Receptor, Epidermal Growth Factor/metabolism; Receptor, Epidermal Growth Factor/physiology; Signal Transduction

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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