GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16712835
| Citation |
McDonald, JA, Pinheiro, EM, Kadlec, L, Schupbach, T and Montell, DJ (2006) Multiple EGFR ligands participate in guiding migrating border cells. Dev. Biol. 296:94-103 |
|---|---|
| Abstract |
Cell migration is an important feature of embryonic development as well as tumor metastasis. Border cells in the Drosophila ovary have emerged as a useful in vivo model for uncovering the molecular mechanisms that control many aspects of cell migration including guidance. It was previously shown that two receptor tyrosine kinases, epidermal growth factor receptor (EGFR) and PDGF- and VEGF-related receptor (PVR), together contribute to border cell migration. Whereas the ligand for PVR, PVF1, is known to guide border cells, it is unclear which of the four activating EGFR ligands function in this process. We developed an assay to detect the ability of secreted factors to reroute migrating border cells in vivo and tested the activity of EGFR ligands compared to PVF1. Two ligands, Keren and Spitz, guided border cells whereas the other ligands, Gurken and Vein, did not. In addition, only Keren and Spitz were expressed at the appropriate stage in the oocyte, the target of border cell migration. Therefore, a complex combination of EGFR and PVR ligands together guide border cells to the oocyte. |
| Links |
PubMed Online version:10.1016/j.ydbio.2006.04.438 |
| Keywords |
Animals; Cell Movement/physiology; Drosophila Proteins/agonists; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Drosophila melanogaster/cytology; Drosophila melanogaster/physiology; Egg Proteins/metabolism; Egg Proteins/physiology; Epidermal Growth Factor/physiology; Female; Ligands; Membrane Proteins/physiology; Neuregulins/physiology; Ovary/cytology; Ovary/physiology; Protein Kinases/physiology; Receptor, Epidermal Growth Factor/agonists; Receptor, Epidermal Growth Factor/physiology; Receptors, Invertebrate Peptide/agonists; Receptors, Invertebrate Peptide/physiology; Transforming Growth Factor alpha/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
