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PMID:11141565
| Citation |
Duchek, P and Rørth, P (2001) Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 291:131-3 |
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| Abstract |
Directed cell migration is important for many aspects of normal animal development, but little is known about how cell migrations are guided or the mechanisms by which guidance cues are translated into directed cell movement. Here we present evidence that signaling mediated by the epidermal growth factor receptor (EGFR) guides dorsal migration of border cells during Drosophila oogenesis. The transforming growth factor-alpha (TGF-alpha)-like ligand Gurken appears to serve as the guidance cue. To mediate this guidance function, EGFR signals via a pathway that is independent of Raf-MAP kinase and receptor-specific. |
| Links |
PubMed Online version:10.1126/science.291.5501.131 |
| Keywords |
Animals; Cell Movement; Drosophila Proteins; Drosophila melanogaster/cytology; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Female; Insect Proteins/genetics; Insect Proteins/physiology; Ligands; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases/metabolism; Mutation; Neuregulins; Oocytes/cytology; Oocytes/physiology; Oogenesis; Ovarian Follicle/cytology; Ovarian Follicle/physiology; Proto-Oncogene Proteins c-raf/metabolism; Receptor, Epidermal Growth Factor/genetics; Receptor, Epidermal Growth Factor/physiology; Signal Transduction; Transforming Growth Factor alpha; Transforming Growth Factors/genetics; Transforming Growth Factors/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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