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PMID:10934021
| Citation |
Kubota, K, Goto, S, Eto, K and Hayashi, S (2000) EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila. Development 127:3769-76 |
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| Abstract |
Wing and leg precursors of Drosophila are recruited from a common pool of ectodermal cells expressing the homeobox gene Dll. Induction by Dpp promotes this cell fate decision toward the wing and proximal leg. We report here that the receptor tyrosine kinase EGFR antagonizes the wing-promoting function of Dpp and allows recruitment of leg precursor cells from uncommitted ectodermal cells. By monitoring the spatial distribution of cells responding to Dpp and EGFR, we show that nuclear transduction of the two signals peaks at different position along the dorsoventral axis when the fates of wing and leg discs are specified and that the balance of the two signals assessed within the nucleus determines the number of cells recruited to the wing. Differential activation of the two signals and the cross talk between them critically affect this cell fate choice. |
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| Keywords |
Animals; Cell Differentiation; Drosophila; Drosophila Proteins; Enzyme Activation; Extremities/growth & development; Insect Proteins/genetics; Insect Proteins/metabolism; Mitogen-Activated Protein Kinases/metabolism; Receptor, Epidermal Growth Factor/genetics; Receptor, Epidermal Growth Factor/metabolism; Signal Transduction/physiology; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism; Wing/cytology; Wing/growth & development |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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