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PMID:17055987
| Citation |
Parker, J (2006) Control of compartment size by an EGF ligand from neighboring cells. Curr. Biol. 16:2058-65 |
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| Abstract |
Insect bodies are subdivided into anterior (A) and posterior (P) compartments: cohesive fields of distinct cell lineage and cell affinity . Like organs in many animal species, compartments can develop to normal sizes despite considerable variation in cell division . This implies that overall compartment dimensions are subject to genetic control, but the mechanisms are unknown. Here, studying Drosophila's embryonic segments, I show that P compartment dimensions depend on epidermal growth factor receptor (EGFR) signaling. I suggest the primary activating ligand is Spitz, emanating from neighboring A compartment cells. Spi/EGFR activity stimulates P compartment cell enlargement and survival, but evidence is presented that Spitz is secreted in limited amounts, so that increasing the number of cells within the P compartment causes the per-cell Spitz level to drop. This leads to compensatory apoptosis and cell-size reductions that preserve compartment dimensions. Conversely, I propose that lowering P compartment cell numbers enhances per-cell Spitz availability; this increases cell survival and cell size, again safeguarding compartment size. The results argue that the gauging of P compartment size is due, at least in part, to cells surviving and growing according to Spi availability. These data offer mechanistic insight into how diffusible molecules control organ size. |
| Links |
PubMed Online version:10.1016/j.cub.2006.08.092 |
| Keywords |
Animals; Apoptosis/physiology; Body Patterning/physiology; Body Weights and Measures; Drosophila/embryology; Drosophila Proteins/metabolism; Embryo, Nonmammalian/physiology; Epidermal Growth Factor/metabolism; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Membrane Proteins/metabolism; Receptor, Epidermal Growth Factor/metabolism; Signal Transduction/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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