PMID:15511643

Citation	Cordero, J, Jassim, O, Bao, S and Cagan, R (2004) A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye. Mech. Dev. 121:1523-30
Abstract	Programmed cell death (PCD) is utilized in a wide variety of tissues to refine structure in developing tissues and organs. However, little is understood about the mechanisms that, within a developing epithelium, combine signals to selectively remove some cells while sparing essential neighbors. One popular system for studying this question is the developing Drosophila pupal retina, where excess interommatidial support cells are removed to refine the patterned ommatidial array. In this paper, we present data indicating that PCD occurs earlier within the pupal retina than previously demonstrated. As with later PCD, this death is dependent on Notch activity. Surprisingly, altering Drosophila Epidermal Growth Factor Receptor or Ras pathway activity had no effect on this death. Instead, our evidence indicates a role for Wingless signaling to provoke this cell death. Together, these signals regulate an intermediate step in the selective removal of unneeded interommatidial cells that is necessary for a precise retinal pattern.
Links	PubMed Online version:10.1016/j.mod.2004.07.004
Keywords	Animals; Apoptosis/physiology; Drosophila/growth & development; Drosophila/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Membrane Proteins/metabolism; Neuropeptides/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Pupa/metabolism; Receptor, Epidermal Growth Factor/metabolism; Receptors, Notch; Retina/growth & development; Retina/metabolism; Signal Transduction/physiology; Tumor Suppressor Protein p53/metabolism; Wnt1 Protein; ras Proteins/metabolism
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