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MOUSE:MERTK

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Mertk (synonyms: Mer)
Protein Name(s) Tyrosine-protein kinase Mer

Proto-oncogene c-Mer Receptor tyrosine kinase MerTK

External Links
UniProt Q60805
EMBL U21301
L11625
CCDS CCDS16716.1
PIR I49276
RefSeq NP_032613.1
UniGene Mm.239655
ProteinModelPortal Q60805
SMR Q60805
IntAct Q60805
STRING 10090.ENSMUSP00000014505
MEROPS I43.001
PhosphoSite Q60805
MaxQB Q60805
PaxDb Q60805
PRIDE Q60805
DNASU 17289
Ensembl ENSMUST00000014505
GeneID 17289
KEGG mmu:17289
UCSC uc008mgt.1
CTD 10461
MGI MGI:96965
eggNOG COG0515
GeneTree ENSGT00770000120499
HOGENOM HOG000231685
HOVERGEN HBG006346
InParanoid Q60805
KO K05117
OMA NEIGWSA
OrthoDB EOG77DJ5C
PhylomeDB Q60805
TreeFam TF317402
BRENDA 2.7.10.1
Reactome REACT_225233
NextBio 291808
PRO PR:Q60805
Proteomes UP000000589
Bgee Q60805
CleanEx MM_MERTK
ExpressionAtlas Q60805
Genevestigator Q60805
GO GO:0005737
GO:0005615
GO:0016021
GO:0001750
GO:0016028
GO:0005524
GO:0004714
GO:0043277
GO:0001779
GO:0051250
GO:0030168
GO:0050766
GO:0043491
GO:0060041
GO:0032940
GO:0007283
GO:0034446
GO:0060068
Gene3D 2.60.40.10
InterPro IPR003961
IPR007110
IPR013783
IPR003599
IPR011009
IPR000719
IPR017441
IPR001245
IPR008266
IPR020635
Pfam PF00041
PF07714
PRINTS PR00109
SMART SM00060
SM00409
SM00219
SUPFAM SSF49265
SSF56112
PROSITE PS50853
PS50835
PS00107
PS50011
PS00109

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0002834

regulation of response to tumor cell

PMID:23867499[1]

ECO:0000316

P

Figure 1 Mice with MerTK–/– microenvironment experienced decreased tumor malignancy.

Missing: with/from
CACAO 9372

involved_in

GO:0043277

apoptotic cell clearance

PMID:18159085[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015380
FB:FBgn0024245
FB:FBgn0033791
PANTHER:PTN002356460
UniProtKB:A6QR62
UniProtKB:O15146
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P17948
UniProtKB:P21860
UniProtKB:P35916
UniProtKB:Q01973
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16288
UniProtKB:Q16620

C

Seeded From UniProt

complete

enables

GO:0017147

Wnt-protein binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015380
FB:FBgn0033791
MGI:MGI:101766
PANTHER:PTN002521290

F

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347244
MGI:MGI:96969
PANTHER:PTN002814495
RGD:3082
ZFIN:ZDB-GENE-041014-1

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101766
PANTHER:PTN002521290

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347244
MGI:MGI:96969
PANTHER:PTN002814495
RGD:3082
WB:WBGene00020504
ZFIN:ZDB-GENE-041014-1

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0283499
MGI:MGI:104757
MGI:MGI:109378
MGI:MGI:1096337
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95278
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95523
MGI:MGI:95524
MGI:MGI:95525
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96575
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97531
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99216
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2612
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
RGD:69323
UniProtKB:A6QR62
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:P54764
UniProtKB:Q02763
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q15375
UniProtKB:Q16288
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
WB:WBGene00001184
WB:WBGene00006868
ZFIN:ZDB-GENE-020503-1
ZFIN:ZDB-GENE-020503-2
ZFIN:ZDB-GENE-060503-14
ZFIN:ZDB-GENE-070713-2
ZFIN:ZDB-GENE-980526-255
ZFIN:ZDB-GENE-980526-326
ZFIN:ZDB-GENE-990415-62

P

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347244
PANTHER:PTN001231011
RGD:69283
UniProtKB:P30530
UniProtKB:Q12866

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0011829
FB:FBgn0015380
FB:FBgn0032006
FB:FBgn0283499
MGI:MGI:103581
MGI:MGI:104771
MGI:MGI:109378
MGI:MGI:98277
MGI:MGI:99611
PANTHER:PTN002356460
RGD:1560587
RGD:3213
RGD:3214
RGD:70957
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q02763
UniProtKB:Q16620
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00000898

C

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003733
FB:FBgn0040505
FB:FBgn0283499
MGI:MGI:109378
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95524
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07333
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00006868
WB:WBGene00020504
ZFIN:ZDB-GENE-980526-255

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000107

negative regulation of leukocyte apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q12866

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097350

neutrophil clearance

PMID:23878224[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1347244

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060068

vagina development

PMID:18393392[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104294
MGI:MGI:1347244

P

results_in_development_of:(EMAPA:18986)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060041

retina development in camera-type eye

PMID:21052544[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_development_of:(EMAPA:17168)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051250

negative regulation of lymphocyte activation

PMID:11452127[7]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104294
MGI:MGI:1347244

P

regulates_o_occurs_in:(CL:0000542)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050766

positive regulation of phagocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q12866

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043491

protein kinase B signaling

PMID:15650770[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95660

P

occurs_in:(CL:0000233)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043277

apoptotic cell clearance

PMID:23878224[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1347244

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043277

apoptotic cell clearance

PMID:18159085[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104294
MGI:MGI:1347244

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043277

apoptotic cell clearance

PMID:17442946[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387768

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034446

substrate adhesion-dependent cell spreading

PMID:15650770[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387765

P

occurs_in:(CL:0000233)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032940

secretion by cell

PMID:15650770[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387765

P

occurs_in:(CL:0000233)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030168

platelet activation

PMID:15650770[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387765

P

Seeded From UniProt

complete

part_of

GO:0016028

rhabdomere

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q12866

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:10227296[10]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104294
MGI:MGI:1347244

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006909

phagocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q12866

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006909

phagocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69283

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69283

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q12866

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q12866

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001818

negative regulation of cytokine production

PMID:23878224[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1347244

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001779

natural killer cell differentiation

PMID:16751775[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104294
MGI:MGI:1347244

P

results_in_acquisition_of_features_of:(CL:0000623)

Seeded From UniProt

complete

part_of

GO:0001750

photoreceptor outer segment

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69283

C

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P57097
ensembl:ENSRNOP00000023419

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P57097
ensembl:ENSRNOP00000023419

P

Seeded From UniProt

complete

part_of

GO:0001750

photoreceptor outer segment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P57097
ensembl:ENSRNOP00000023419

C

Seeded From UniProt

complete

involved_in

GO:2000107

negative regulation of leukocyte apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q12866
ensembl:ENSP00000295408

P

Seeded From UniProt

complete

involved_in

GO:0050766

positive regulation of phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q12866
ensembl:ENSP00000295408

P

Seeded From UniProt

complete

part_of

GO:0016028

rhabdomere

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q12866
ensembl:ENSP00000295408

C

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q12866
ensembl:ENSP00000295408

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q12866
ensembl:ENSP00000295408

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q12866
ensembl:ENSP00000295408

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.1

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Cook, RS et al. (2013) MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis. J. Clin. Invest. 123 3231-42 PubMed GONUTS page
  2. 2.0 2.1 Xiong, W et al. (2008) Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction 135 77-87 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 Bosurgi, L et al. (2013) Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proc. Natl. Acad. Sci. U.S.A. 110 13091-6 PubMed GONUTS page
  5. Wu, H et al. (2008) High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol. Reprod. Dev. 75 1775-82 PubMed GONUTS page
  6. Won, J et al. (2011) Mouse model resources for vision research. J Ophthalmol 2011 391384 PubMed GONUTS page
  7. Lu, Q & Lemke, G (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293 306-11 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Angelillo-Scherrer, A et al. (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J. Clin. Invest. 115 237-46 PubMed GONUTS page
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