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Category:Team Bfast Taco

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableHUMAN:TARARthompson, Team Bfast Taco2014-02-02 17:10:26 CSTGO:0015629 actin cytoskeleton (C)PMID:9190212ECO:0000314 direct assay evidence used in manual assertion

In this study, the role of the cytoskeleton in LFA-1 activation and demonstrate that filamentous actin (F-actin) was shown to both enhance and inhibit LFA-1-mediated adhesion, depending on the distribution of LFA-1 on the cell surface.

challenge
unacceptableMOUSE:P85AKfree, Team Bfast Taco2014-02-01 03:13:57 CSTGO:0032762 mast cell cytokine production (P)PMID:24454942ECO:0000315 mutant phenotype evidence used in manual assertion

Fig. 6D shows PI3K KO mice exhibit lower expression of cytokines in mucosal cells compared to WT mice. Fig. 6C shows similar cytokine expression in KO and WT mice, suggesting that PI3K is involved in gastrointestinal mast cell cytokine production and not systemic mast cell cytokine production.

challenge
unacceptableMOUSE:ACHA7Kfree, Team Bfast Taco2014-02-01 02:32:55 CSTGO:0050728 negative regulation of inflammatory response (P)PMID:24454942ECO:0000314 direct assay evidence used in manual assertion

Fig. 8C shows administration of GTS-21, specific agonist of α7nAchR, significantly reduces FA occurrence.

challenge
unacceptableHUMAN:OPSDRthompson, Team Bfast Taco2014-01-31 16:06:19 CSTGO:0071482 cellular response to light stimulus (P)PMID:8643442ECO:0000315 mutant phenotype evidence used in manual assertion

Comparisons between the mutant, incorrectly folded Rhodopsin and the correctly folded Rhodopsin resulted in a negative influence on the ability to interpret a light stimulus.

challenge
unacceptableHUMAN:PROCRthompson, Team Bfast Taco2014-01-31 15:50:51 CSTGO:0030195 negative regulation of blood coagulation (P)PMID:9529319ECO:0000304 author statement supported by traceable reference used in manual assertion

EPCR enables significant levels of protein C activation. These results suggest that the protein C anticoagulation pathway is important for the regulation of blood coagulation not only in microvessels but also in large vessels.

challenge
unacceptableHUMAN:PEPA5Rthompson, Team Bfast Taco2014-01-31 15:35:24 CSTGO:0006508 proteolysis (P)other:PMC1712889ECO:0000314 direct assay evidence used in manual assertion

he techniques of starch gel electrophoresis, immunoelectrophoresis and high resolutiongelfiltrationhavebeenusedtoinvestigatethepepticcleavageofhuman G-myeloma proteins of the four known subclasses.

challenge
updatedbyinstructorRAT:TAURthompson, Team Bfast Taco2014-01-29 20:56:19 CSTGO:0005874 microtubule (C)PMID:1396588ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows that Tau was localized to microtubules using an anti-Tau and an anti-tubulin antibody.

challenge
unacceptableMOUSE:ACHB2Kfree, Team Bfast Taco2014-01-27 23:56:13 CSTGO:0007271 synaptic transmission, cholinergic (P)PMID:24223920ECO:0000314 direct assay evidence used in manual assertion

Figure 3 suggests that β2nAchR is critical to cholinergic signaling as DHBE, specific antagonist to β2nAchR, blocks nicotine inhibition. Other nonspecific antagonists do not block nicotine inhibition.

challenge
updatedbyinstructorRABIT:EAA3Kfree, Team Bfast Taco2014-01-27 21:58:51 CSTGO:0070779 D-aspartate import (P)PMID:20424168ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1 shows uptake of substrates is reduced with mutation of Met-367.

challenge
updatedbyinstructorMOUSE:ACHB4Kfree, Team Bfast Taco2014-01-27 21:02:25 CSTGO:0051971 positive regulation of transmission of nerve impulse (P)PMID:12606764ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 suggests the B4 subunit of nAchR helps transmit nerve impulses. At low concentrations, the ganglionic blocker C6 prevents transmission of vagal stimulation in KO mice. WT mice however still receive the transmission of the nerve impulse, suggesting B4 subunit of nAchR is involved in transmissions of nerve impulses. The authors state "the bradycardic effect was significantly attenuated in β4−/− mice." Thus, the subunit must maintain the extent of a nerve pulse.

challenge
unacceptableHUMAN:LDLRKfree, Team Bfast Taco2014-01-27 16:27:37 CSTGO:0010628 positive regulation of gene expression (P)PMID:24358207ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows stimulation to nicotine in OSCC induces LDLR expression.

challenge

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Pages in category "Team Bfast Taco"

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