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PMID:24223920
| Citation |
Nemethova, A, Michel, K, Gomez-Pinilla, PJ, Boeckxstaens, GE and Schemann, M (2013) Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor. PLoS ONE 8:e79264 |
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| Abstract |
The cholinergic anti-inflammatory pathway is an endogenous mechanism by which the autonomic nervous system attenuates macrophage activation via nicotinic acetylcholine receptors (nAChR). This concept has however not been demonstrated at a cellular level in intact tissue. To this end, we have studied the effect of nicotine on the activation of resident macrophages in a mouse stomach preparation by means of calcium imaging. |
| Links |
PubMed PMC3815157 Online version:10.1371/journal.pone.0079264 |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0007271: synaptic transmission, cholinergic |
ECO:0000314: |
P |
Figure 3 suggests that β2nAchR is critical to cholinergic signaling as DHBE, specific antagonist to β2nAchR, blocks nicotine inhibition. Other nonspecific antagonists do not block nicotine inhibition. |
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See also
References
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