HUMAN:OPSD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RHO (synonyms: OPN2)
Protein Name(s)	Rhodopsin Opsin-2
External Links
UniProt	P08100
EMBL	U49742 AB065668 BX537381 BC112104 BC112106 U16824 S81166
CCDS	CCDS3063.1
PIR	A41200
RefSeq	NP_000530.1
UniGene	Hs.247565
ProteinModelPortal	P08100
SMR	P08100
BioGrid	111942
IntAct	P08100
STRING	9606.ENSP00000296271
DrugBank	DB01159
TCDB	9.A.14.1.2
PhosphoSite	P08100
UniCarbKB	P08100
DMDM	129207
PaxDb	P08100
PRIDE	P08100
DNASU	6010
Ensembl	ENST00000296271
GeneID	6010
KEGG	hsa:6010
UCSC	uc003emt.3
CTD	6010
GeneCards	GC03P129247
GeneReviews	RHO
HGNC	HGNC:10012
MIM	180380 610445 613731
neXtProt	NX_P08100
Orphanet	215 791 52427
PharmGKB	PA34390
eggNOG	NOG311294
GeneTree	ENSGT00760000118977
HOGENOM	HOG000253932
HOVERGEN	HBG107442
InParanoid	P08100
KO	K04250
OMA	LAAYMFM
OrthoDB	EOG72NRQJ
PhylomeDB	P08100
TreeFam	TF324998
Reactome	REACT_160156 REACT_163919 REACT_163932 REACT_18426 REACT_19231
SignaLink	P08100
ChiTaRS	RHO
GeneWiki	Rhodopsin
GenomeRNAi	6010
NextBio	23449
PRO	PR:P08100
Proteomes	UP000005640
Bgee	P08100
CleanEx	HS_RHO
Genevestigator	P08100
GO	GO:0005911 GO:0005794 GO:0005887 GO:0097381 GO:0001917 GO:0060342 GO:0001750 GO:0042622 GO:0005886 GO:0030867 GO:0004930 GO:0046872 GO:0009881 GO:0016918 GO:0007186 GO:0007603 GO:0006468 GO:0018298 GO:0009585 GO:0022400 GO:0060041 GO:0001523 GO:0016056 GO:0007601
Gene3D	4.10.840.10
InterPro	IPR000276 IPR017452 IPR001760 IPR027430 IPR000732 IPR019477
Pfam	PF00001 PF10413
PRINTS	PR00237 PR00238 PR00579
PROSITE	PS00237 PS50262 PS00238

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0071482	cellular response to light stimulus	PMID:8643442^[1]	ECO:0000315			P	Comparisons between the mutant, incorrectly folded Rhodopsin and the correctly folded Rhodopsin resulted in a negative influence on the ability to interpret a light stimulus.	complete CACAO 9366
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02699	C	Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02699	F	Seeded From UniProt	complete
enables	GO:0005502	11-cis retinal binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02699	F	Seeded From UniProt	complete
involved_in	GO:0016056	rhodopsin mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02699	P	Seeded From UniProt	complete
part_of	GO:0097381	photoreceptor disc membrane	PMID:25664179^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016038	absorption of visible light	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02699	P	Seeded From UniProt	complete
involved_in	GO:0016038	absorption of visible light	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:L8I7L1	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:2218504^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0060342	photoreceptor inner segment membrane	PMID:19934218^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0042622	photoreceptor outer segment membrane	PMID:19934218^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071482	cellular response to light stimulus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002940 MGI:MGI:97914 PANTHER:PTN000662115 UniProtKB:D0E2W5 UniProtKB:F1NEY8	P	Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002940 FB:FBgn0003249 FB:FBgn0003250 FB:FBgn0014019 FB:FBgn0019940 MGI:MGI:1353425 PANTHER:PTN000662115 RGD:621701 UniProtKB:D0E2W5 UniProtKB:F1NEY2 UniProtKB:F1NEY8 UniProtKB:P02699 UniProtKB:Q9UHM6	F	Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002940 FB:FBgn0014019 FB:FBgn0019940 MGI:MGI:1353425 MGI:MGI:97914 PANTHER:PTN000662115 RGD:621701 UniProtKB:F1RAF0 UniProtKB:Q9UHM6 ZFIN:ZDB-GENE-040724-51 ZFIN:ZDB-GENE-061201-30 ZFIN:ZDB-GENE-081105-91	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000662115 UniProtKB:P08100 ZFIN:ZDB-GENE-070111-2 ZFIN:ZDB-GENE-080415-3 ZFIN:ZDB-GENE-110622-1	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1929473 PANTHER:PTN000662115 UniProtKB:P02699	C	Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097692 MGI:MGI:97914 MGI:MGI:99438 PANTHER:PTN000662150 RGD:3573 RGD:620978 RGD:621033 UniProtKB:F1P3Y2 UniProtKB:P08100 UniProtKB:P22328 UniProtKB:P22329 ZFIN:ZDB-GENE-990604-42	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11767049^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	PMID:11767049^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	PMID:23704327^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	PMID:11767049^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071482	cellular response to light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0050953	sensory perception of light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0045494	photoreceptor cell maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0009583	detection of light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	P	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	C	Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	C	Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15409 ensembl:ENSMUSP00000032471	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000732 InterPro:IPR001760	P	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001760	P	Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000732	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000732 InterPro:IPR001760 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0016056	rhodopsin mediated signaling pathway	PMID:8107847^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007603	phototransduction, visible light	PMID:1418997^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:2218504^[3] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8253795^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:8107847^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0097381	photoreceptor disc membrane	Reactome:R-HSA-8982640 Reactome:R-HSA-8982637 Reactome:R-HSA-74948 Reactome:R-HSA-74101 Reactome:R-HSA-420883 Reactome:R-HSA-419841 Reactome:R-HSA-2632521 Reactome:R-HSA-2581474 Reactome:R-HSA-2454118	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	Reactome:R-HSA-5623527	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030660	Golgi-associated vesicle membrane	Reactome:R-HSA-5623527 Reactome:R-HSA-5623525 Reactome:R-HSA-5623524	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0022400	regulation of rhodopsin mediated signaling pathway	Reactome:R-HSA-2514859	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-2453902	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-5623525 Reactome:R-HSA-5623521 Reactome:R-HSA-5623519 Reactome:R-HSA-5623513 Reactome:R-HSA-5620921 Reactome:R-HSA-5620914	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0681	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0844	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
enables	GO:0009881	photoreceptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0600	F	Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P	Seeded From UniProt	complete
involved_in	GO:0018298	protein-chromophore linkage	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0157	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0458	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Liu, X et al. (1996) Structure and function in rhodopsin: correct folding and misfolding in two point mutants in the intradiscal domain of rhodopsin identified in retinitis pigmentosa. Proc. Natl. Acad. Sci. U.S.A. 93 4554-9 PubMed GONUTS page
↑ Chuang, JZ et al. (2015) Ultrastructural visualization of trans-ciliary rhodopsin cargoes in mammalian rods. Cilia 4 4 PubMed GONUTS page
↑ ^3.0 ^3.1 Franke, RR et al. (1990) Rhodopsin mutants that bind but fail to activate transducin. Science 250 123-5 PubMed GONUTS page
↑ ^4.0 ^4.1 Kosmaoglou, M et al. (2009) A dual role for EDEM1 in the processing of rod opsin. J. Cell. Sci. 122 4465-72 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Uchio-Yamada, K et al. (2001) Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome. J. Vet. Med. Sci. 63 1171-8 PubMed GONUTS page
↑ Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page
↑ ^8.0 ^8.1 Rao, VR et al. (1994) Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness. Nature 367 639-42 PubMed GONUTS page
↑ Olsson, JE et al. (1992) Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron 9 815-30 PubMed GONUTS page
↑ Sung, CH et al. (1993) Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain. J. Biol. Chem. 268 26645-9 PubMed GONUTS page

[PMID:8643442-1] Liu, X et al. (1996) Structure and function in rhodopsin: correct folding and misfolding in two point mutants in the intradiscal domain of rhodopsin identified in retinitis pigmentosa. Proc. Natl. Acad. Sci. U.S.A. 93 4554-9 PubMed GONUTS page

[PMID:25664179-2] Chuang, JZ et al. (2015) Ultrastructural visualization of trans-ciliary rhodopsin cargoes in mammalian rods. Cilia 4 4 PubMed GONUTS page

[PMID:2218504-3] 3.0 ^3.1 Franke, RR et al. (1990) Rhodopsin mutants that bind but fail to activate transducin. Science 250 123-5 PubMed GONUTS page

[PMID:19934218-4] 4.0 ^4.1 Kosmaoglou, M et al. (2009) A dual role for EDEM1 in the processing of rod opsin. J. Cell. Sci. 122 4465-72 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11767049-6] 6.0 ^6.1 ^6.2 Uchio-Yamada, K et al. (2001) Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome. J. Vet. Med. Sci. 63 1171-8 PubMed GONUTS page

[PMID:23704327-7] Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page

[PMID:8107847-8] 8.0 ^8.1 Rao, VR et al. (1994) Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness. Nature 367 639-42 PubMed GONUTS page

[PMID:1418997-9] Olsson, JE et al. (1992) Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron 9 815-30 PubMed GONUTS page

[PMID:8253795-10] Sung, CH et al. (1993) Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain. J. Biol. Chem. 268 26645-9 PubMed GONUTS page

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HUMAN:OPSD

Contents

Annotations

Notes

References

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