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PMID:24358207
| Citation |
Ito, S, Gojoubori, T, Tsunoda, K, Yamaguchi, Y, Asano, M, Goke, E, Koshi, R, Sugano, N, Yoshinuma, N, Komiyama, K and Ito, K (2013) Nicotine-induced expression of low-density lipoprotein receptor in oral epithelial cells. PLoS ONE 8:e82563 |
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| Abstract |
Nicotine use is one of the most important risk factors for the development of cardiovascular and periodontal diseases. Numerous reports have suggested the possible contribution of disturbed lipid metabolism for the development of both disease groups. Despite these observations, little is known about the relationship between tobacco smoking and the development of these diseases. Our previous microarray data revealed that nicotine induced low-density lipoprotein receptor (LDLR) expression in oral epithelial cells (OECs). The aim of the present study was to confirm nicotine-mediated LDLR induction and to elucidate the signaling mechanisms leading to the augmented expression of LDLR in OECs. |
| Links |
PubMed PMC3864957 Online version:10.1371/journal.pone.0082563 |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0010628: positive regulation of gene expression |
ECO:0000314: |
P |
Figure 1 shows stimulation to nicotine in OSCC induces LDLR expression. |
complete | ||||
See also
References
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