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HUMAN:TARA
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TRIOBP (synonyms: KIAA1662, TARA) | |
| Protein Name(s) | TRIO and F-actin-binding protein
Protein Tara Trio-associated repeat on actin | |
| External Links | ||
| UniProt | Q9H2D6 | |
| EMBL | AF281030 DQ228003 DQ228004 DQ228005 DQ278603 Z83844 BC003618 BC004303 BC013278 BC022200 AB015343 AB051449 | |
| CCDS | CCDS33644.1 CCDS43015.1 CCDS43016.1 | |
| RefSeq | NP_001034230.1 NP_008963.3 NP_619538.2 | |
| UniGene | Hs.533030 | |
| ProteinModelPortal | Q9H2D6 | |
| BioGrid | 116261 | |
| IntAct | Q9H2D6 | |
| MINT | MINT-1397991 | |
| PhosphoSite | Q9H2D6 | |
| DMDM | 90110075 | |
| MaxQB | Q9H2D6 | |
| PaxDb | Q9H2D6 | |
| PRIDE | Q9H2D6 | |
| DNASU | 11078 | |
| Ensembl | ENST00000403663 ENST00000406386 ENST00000407319 | |
| GeneID | 11078 | |
| KEGG | hsa:11078 | |
| UCSC | uc003atq.1 uc003ats.1 | |
| CTD | 11078 | |
| GeneCards | GC22P038092 | |
| GeneReviews | TRIOBP | |
| HGNC | HGNC:17009 | |
| HPA | HPA003747 HPA019769 | |
| MIM | 609761 609823 | |
| neXtProt | NX_Q9H2D6 | |
| Orphanet | 90636 | |
| PharmGKB | PA142670699 | |
| eggNOG | NOG12793 | |
| GeneTree | ENSGT00530000063678 | |
| HOVERGEN | HBG094025 | |
| InParanoid | Q9H2D6 | |
| OMA | PYCDLPR | |
| OrthoDB | EOG773XKP | |
| PhylomeDB | Q9H2D6 | |
| TreeFam | TF343361 | |
| ChiTaRS | TRIOBP | |
| GeneWiki | TRIOBP | |
| GenomeRNAi | 11078 | |
| NextBio | 42114 | |
| PRO | PR:Q9H2D6 | |
| Proteomes | UP000005640 | |
| Bgee | Q9H2D6 | |
| ExpressionAtlas | Q9H2D6 | |
| Genevestigator | Q9H2D6 | |
| GO | GO:0015629 GO:0005737 GO:0005925 GO:0005815 GO:0030496 GO:0005634 GO:0051015 GO:0017049 GO:0045159 GO:0031625 GO:0030047 GO:0051016 GO:0007067 GO:1900026 | |
| Gene3D | 2.30.29.30 | |
| InterPro | IPR001849 IPR011993 IPR029908 | |
| PANTHER | PTHR17271:SF10 | |
| Pfam | PF00169 | |
| SMART | SM00233 | |
| PROSITE | PS50003 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0015629 |
actin cytoskeleton |
ECO:0000314 |
C |
In this study, the role of the cytoskeleton in LFA-1 activation and demonstrate that filamentous actin (F-actin) was shown to both enhance and inhibit LFA-1-mediated adhesion, depending on the distribution of LFA-1 on the cell surface. |
complete | |||||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051016 |
barbed-end actin filament capping |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045159 |
myosin II binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030047 |
actin modification |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017049 |
GTP-Rho binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900026 |
positive regulation of substrate adhesion-dependent cell spreading |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051015 |
actin filament binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900026 |
positive regulation of substrate adhesion-dependent cell spreading |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99KW3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060088 |
auditory receptor cell stereocilium organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99KW3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007605 |
sensory perception of sound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99KW3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032956 |
regulation of actin cytoskeleton organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051015 |
actin filament binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030496 |
midbody |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lub, M et al. (1997) Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1. Mol. Biol. Cell 8 341-51 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Seipel, K et al. (2001) Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. J. Cell. Sci. 114 389-99 PubMed GONUTS page
- ↑ Yu, J et al. (2008) The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. Biochem. Biophys. Res. Commun. 367 805-12 PubMed GONUTS page
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