User:Kfree

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HUMAN:LDLR	2014-01-27 16:27:37 CST	GO:0010628 positive regulation of gene expression (P)	PMID:24358207	ECO:0000314 direct assay evidence used in manual assertion	Figure 1 shows stimulation to nicotine in OSCC induces LDLR expression.	challenge
updatedbyinstructor	MOUSE:ACHB4	2014-01-27 21:02:25 CST	GO:0051971 positive regulation of transmission of nerve impulse (P)	PMID:12606764	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2 suggests the B4 subunit of nAchR helps transmit nerve impulses. At low concentrations, the ganglionic blocker C6 prevents transmission of vagal stimulation in KO mice. WT mice however still receive the transmission of the nerve impulse, suggesting B4 subunit of nAchR is involved in transmissions of nerve impulses. The authors state "the bradycardic effect was significantly attenuated in β4−/− mice." Thus, the subunit must maintain the extent of a nerve pulse.	challenge
updatedbyinstructor	RABIT:EAA3	2014-01-27 21:58:51 CST	GO:0070779 D-aspartate import (P)	PMID:20424168	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1 shows uptake of substrates is reduced with mutation of Met-367.	challenge
unacceptable	MOUSE:ACHB2	2014-01-27 23:56:13 CST	GO:0007271 synaptic transmission, cholinergic (P)	PMID:24223920	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 suggests that β2nAchR is critical to cholinergic signaling as DHBE, specific antagonist to β2nAchR, blocks nicotine inhibition. Other nonspecific antagonists do not block nicotine inhibition.	challenge
unacceptable	MOUSE:ACHA7	2014-02-01 02:32:55 CST	GO:0050728 negative regulation of inflammatory response (P)	PMID:24454942	ECO:0000314 direct assay evidence used in manual assertion	Fig. 8C shows administration of GTS-21, specific agonist of α7nAchR, significantly reduces FA occurrence.	challenge
unacceptable	MOUSE:P85A	2014-02-01 03:13:57 CST	GO:0032762 mast cell cytokine production (P)	PMID:24454942	ECO:0000315 mutant phenotype evidence used in manual assertion	Fig. 6D shows PI3K KO mice exhibit lower expression of cytokines in mucosal cells compared to WT mice. Fig. 6C shows similar cytokine expression in KO and WT mice, suggesting that PI3K is involved in gastrointestinal mast cell cytokine production and not systemic mast cell cytokine production.	challenge

acceptable:0
unacceptable:4
requires_changes:0
flagged:0

Annotations challenged by Kfree

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Kdiawara, Team Lobster Soul	HUMAN:HS90B	GO:0097435 - supramolecular fiber organization (P)	PMID:24466266	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 8
updatedbyinstructor	Fclingen, Team What the Fox Says	ECOLI:LAMB	GO:0015288 - porin activity (F)	PMID:24412198	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4
unacceptable	Fclingen, Team What the Fox Says	ECOLI:ODP1	GO:0071236 - cellular response to antibiotic (P)	PMID:24412198	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
unacceptable	Chong, Team Kitten Me Right Meow	MOUSE:5HT2B	GO:0008144 - obsolete drug binding (F)	PMID:16940156	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
unacceptable	Fpadua, Team Killing Me Smallz	HUMAN:CHK2	GO:0042127 - regulation of cell population proliferation (P)	PMID:14608368	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
updatedbyinstructor	Kfree, Team Bfast Taco	MOUSE:ACHB4	GO:0051971 - positive regulation of transmission of nerve impulse (P)	PMID:12606764	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 5 fixed by Kfree

1 annotations fixed by Kfree

What do the icons mean in the status column?