GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CACAO Spring 2014
|Status||Page||Date/Time||GO Term (Aspect)||Reference||Evidence||Notes||Links|
|HUMAN:LDLR||2014-01-27 16:27:37 CST||GO:0010628 positive regulation of gene expression (P)||PMID:24358207||ECO:0000314 direct assay evidence used in manual assertion|
Figure 1 shows stimulation to nicotine in OSCC induces LDLR expression.
|MOUSE:ACHB4||2014-01-27 21:02:25 CST||GO:0051971 positive regulation of transmission of nerve impulse (P)||PMID:12606764||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 2 suggests the B4 subunit of nAchR helps transmit nerve impulses. At low concentrations, the ganglionic blocker C6 prevents transmission of vagal stimulation in KO mice. WT mice however still receive the transmission of the nerve impulse, suggesting B4 subunit of nAchR is involved in transmissions of nerve impulses. The authors state "the bradycardic effect was significantly attenuated in β4−/− mice." Thus, the subunit must maintain the extent of a nerve pulse.
|RABIT:EAA3||2014-01-27 21:58:51 CST||GO:0070779 D-aspartate import (P)||PMID:20424168||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 1 shows uptake of substrates is reduced with mutation of Met-367.
|MOUSE:ACHB2||2014-01-27 23:56:13 CST||GO:0007271 synaptic transmission, cholinergic (P)||PMID:24223920||ECO:0000314 direct assay evidence used in manual assertion|
Figure 3 suggests that β2nAchR is critical to cholinergic signaling as DHBE, specific antagonist to β2nAchR, blocks nicotine inhibition. Other nonspecific antagonists do not block nicotine inhibition.
|MOUSE:ACHA7||2014-02-01 02:32:55 CST||GO:0050728 negative regulation of inflammatory response (P)||PMID:24454942||ECO:0000314 direct assay evidence used in manual assertion|
Fig. 8C shows administration of GTS-21, specific agonist of α7nAchR, significantly reduces FA occurrence.
|MOUSE:P85A||2014-02-01 03:13:57 CST||GO:0032762 mast cell cytokine production (P)||PMID:24454942||ECO:0000315 mutant phenotype evidence used in manual assertion|
Fig. 6D shows PI3K KO mice exhibit lower expression of cytokines in mucosal cells compared to WT mice. Fig. 6C shows similar cytokine expression in KO and WT mice, suggesting that PI3K is involved in gastrointestinal mast cell cytokine production and not systemic mast cell cytokine production.
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