GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:CHK2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CHEK2 (synonyms: CDS1, CHK2, RAD53)
Protein Name(s) Serine/threonine-protein kinase Chk2

CHK2 checkpoint homolog Cds1 homolog Hucds1 hCds1 Checkpoint kinase 2

External Links
UniProt O96017
EMBL AF086904
AJ131197
AF096279
AY551295
AY551296
AY551297
AY551298
AY551299
AY551300
AY551301
AY551302
AY551303
AY551304
AY551305
CR456418
AF174135
AB040105
AK290754
AF217975
AY800241
AL121825
AL117330
AL117330
AL121825
AL121825
AL117330
AL121825
AL117330
AL121825
AL117330
AL117330
AL121825
AL117330
AL121825
AL117330
AL121825
CH471095
BC004207
CCDS CCDS13843.1
CCDS13844.1
CCDS33629.1
RefSeq NP_001005735.1
NP_001244316.1
NP_009125.1
NP_665861.1
UniGene Hs.291363
Hs.505297
PDB 1GXC
2CN5
2CN8
2W0J
2W7X
2WTC
2WTD
2WTI
2WTJ
2XBJ
2XK9
2XM8
2XM9
2YCF
2YCQ
2YCR
2YCS
2YIQ
2YIR
2YIT
3I6U
3I6W
3VA4
4A9R
4A9S
4A9T
4A9U
4BDA
4BDB
4BDC
4BDD
4BDE
4BDF
4BDG
4BDH
4BDI
4BDJ
4BDK
PDBsum 1GXC
2CN5
2CN8
2W0J
2W7X
2WTC
2WTD
2WTI
2WTJ
2XBJ
2XK9
2XM8
2XM9
2YCF
2YCQ
2YCR
2YCS
2YIQ
2YIR
2YIT
3I6U
3I6W
3VA4
4A9R
4A9S
4A9T
4A9U
4BDA
4BDB
4BDC
4BDD
4BDE
4BDF
4BDG
4BDH
4BDI
4BDJ
4BDK
ProteinModelPortal O96017
SMR O96017
BioGrid 116369
DIP DIP-24270N
IntAct O96017
MINT MINT-124588
BindingDB O96017
ChEMBL CHEMBL2527
GuidetoPHARMACOLOGY 1988
2787
PhosphoSite O96017
MaxQB O96017
PaxDb O96017
PRIDE O96017
DNASU 11200
Ensembl ENST00000328354
ENST00000348295
ENST00000382580
ENST00000402731
ENST00000403642
ENST00000404276
ENST00000405598
ENST00000417588
ENST00000433728
ENST00000448511
GeneID 11200
KEGG hsa:11200
UCSC uc003ads.1
uc003adt.1
uc003adv.1
uc010gvh.1
CTD 11200
GeneCards GC22M029083
HGNC HGNC:16627
HPA CAB002030
HPA001878
MIM 114480
176807
259500
604373
609265
neXtProt NX_O96017
Orphanet 1331
145
524
668
PharmGKB PA404
eggNOG COG0515
GeneTree ENSGT00710000106821
HOVERGEN HBG108055
InParanoid O96017
KO K06641
OMA KFAIGSE
OrthoDB EOG7C5M7Z
PhylomeDB O96017
TreeFam TF101082
BRENDA 2.7.11.1
Reactome REACT_1614
REACT_897
SignaLink O96017
EvolutionaryTrace O96017
GeneWiki CHEK2
GenomeRNAi 11200
NextBio 42629
PRO PR:O96017
Proteomes UP000005640
Bgee O96017
ExpressionAtlas O96017
Genevestigator O96017
GO GO:0005654
GO:0016605
GO:0005524
GO:0042802
GO:0046872
GO:0042803
GO:0019901
GO:0004674
GO:0031625
GO:0044257
GO:0006974
GO:0000077
GO:0006975
GO:0006302
GO:0000086
GO:0008630
GO:0045893
GO:0046777
GO:0006468
GO:0050821
GO:0042176
GO:0006355
GO:0090399
GO:0010332
GO:0042770
GO:0072428
GO:0090307
GO:0006351
Gene3D 2.60.200.20
InterPro IPR000253
IPR011009
IPR000719
IPR002290
IPR008271
IPR008984
Pfam PF00498
PF00069
SMART SM00240
SM00220
SUPFAM SSF49879
SSF56112
PROSITE PS50006
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001302

replicative cell aging

PMID:22851694[1]

ECO:0000315

P

Figure 1 B and C show the effect of suppressing CHEK2 on replicative senescence.

complete
CACAO 7036

GO:0042127

regulation of cell proliferation

PMID:14608368[2]

ECO:0000314

P

Figure 1.n. shows that the expression levels of this protein do not differ between senescent and proliferating cells.

complete
CACAO 9424

GO:0042127

regulation of cell proliferation

PMID:14608368[2]

ECO:0000314

P

Figure 1.n. shows that phosphorylation at threonine 68 is upregulated in senescent cells compared to proliferating cells

complete
CACAO 9425

involved_in

GO:0001302

replicative cell aging

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090399

replicative senescence

PMID:15149599[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0000781

chromosome, telomeric region

PMID:15149599[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090307

mitotic spindle assembly

PMID:20364141[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072428

signal transduction involved in intra-S DNA damage checkpoint

PMID:11298456[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

PMID:12717439[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:Q01094)

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:18644861[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:16794575[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17101782[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044257

cellular protein catabolic process

PMID:11298456[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:16794575[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042176

regulation of protein catabolic process

PMID:17101782[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:22266820[10]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O76064

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:16481012[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9H4B4

F

Seeded From UniProt

complete

part_of

GO:0016605

PML body

PMID:12402044[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:12717439[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:18644861[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:12402044[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006975

DNA damage induced protein phosphorylation

PMID:11298456[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:16481012[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:12717439[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:12717439[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

PMID:18317453[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:12717439[6]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:Q01094)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:16794575[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

PMID:16481012[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044773

mitotic DNA damage checkpoint

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019686
PANTHER:PTN002389571

P

Seeded From UniProt

complete

involved_in

GO:0042770

signal transduction in response to DNA damage

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1355321
PANTHER:PTN002389571
UniProtKB:O96017

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002389571
PomBase:SPAC23A1.06c
PomBase:SPCC1322.08
UniProtKB:Q7YTF7
WB:WBGene00006993

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019686
PANTHER:PTN002389571
PomBase:SPCC1322.08
PomBase:SPCC18B5.11c
RGD:621543
SGD:S000006074
UniProtKB:Q5AVW7

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2152419
PANTHER:PTN002389571
PomBase:SPAC14C4.03
PomBase:SPCC1322.08
PomBase:SPCC18B5.11c
RGD:621543
SGD:S000002259
UniProtKB:O96017

F

Seeded From UniProt

complete

involved_in

GO:0042770

signal transduction in response to DNA damage

PMID:14744935[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:24550317[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18239682[17]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O96017

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16794575[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O96017

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000210

positive regulation of anoikis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:2000002

negative regulation of DNA damage checkpoint

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:1903926

cellular response to bisphenol A

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:1903416

response to glycoside

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:0071157

negative regulation of cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

F

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R019
ensembl:ENSRNOP00000074651

P

Seeded From UniProt

complete

involved_in

GO:0071480

cellular response to gamma radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

P

Seeded From UniProt

complete

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

P

Seeded From UniProt

complete

involved_in

GO:0042770

signal transduction in response to DNA damage

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

P

Seeded From UniProt

complete

involved_in

GO:0010332

response to gamma radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

P

Seeded From UniProt

complete

involved_in

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z265
ensembl:ENSMUSP00000066679

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:9836640[18]
PMID:9889122[19]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:9836640[18]
Reactome:R-HSA-69685
Reactome:R-HSA-69608
Reactome:R-HSA-6804266
Reactome:R-HSA-5683801
Reactome:R-HSA-349426

ECO:0000304

author statement supported by traceable reference used in manual assertion






F

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

PMID:10617473[20]
PMID:9889122[19]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

Reactome:R-HSA-75809

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Reactome:R-HSA-69563

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-75809
Reactome:R-HSA-69891
Reactome:R-HSA-69685
Reactome:R-HSA-69608
Reactome:R-HSA-6804266
Reactome:R-HSA-5683801
Reactome:R-HSA-5683792
Reactome:R-HSA-5683774
Reactome:R-HSA-5683735
Reactome:R-HSA-349426

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Nguyen, CL et al. (2012) Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol. Cell. Biol. 32 3963-77 PubMed GONUTS page
  2. 2.0 2.1 d'Adda di Fagagna, F et al. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 194-8 PubMed GONUTS page
  3. 3.0 3.1 Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
  4. Stolz, A et al. (2010) The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat. Cell Biol. 12 492-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 Falck, J et al. (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410 842-7 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Stevens, C et al. (2003) Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5 401-9 PubMed GONUTS page
  7. 7.0 7.1 Lovly, CM et al. (2008) Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol. Cell. Biol. 28 5874-85 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Oliver, AW et al. (2006) Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO J. 25 3179-90 PubMed GONUTS page
  9. 9.0 9.1 Tan, Y et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol. Cell. Biol. 27 1007-16 PubMed GONUTS page
  10. Feng, L & Chen, J (2012) The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat. Struct. Mol. Biol. 19 201-6 PubMed GONUTS page
  11. 11.0 11.1 11.2 Bahassi, el M et al. (2006) Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutat. Res. 596 166-76 PubMed GONUTS page
  12. 12.0 12.1 Yang, S et al. (2002) PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat. Cell Biol. 4 865-70 PubMed GONUTS page
  13. Bahassi, EM et al. (2008) The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. Oncogene 27 3977-85 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  15. Qu, L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18 261-77 PubMed GONUTS page
  16. Khoury-Haddad, H et al. (2014) PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 111 E728-37 PubMed GONUTS page
  17. Pike, AC et al. (2008) Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 27 704-14 PubMed GONUTS page
  18. 18.0 18.1 Matsuoka, S et al. (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282 1893-7 PubMed GONUTS page
  19. 19.0 19.1 Blasina, A et al. (1999) A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr. Biol. 9 1-10 PubMed GONUTS page
  20. Bell, DW et al. (1999) Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286 2528-31 PubMed GONUTS page