MOUSE:ACHA7

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Chrna7 (synonyms: Acra7)
Protein Name(s)	Neuronal acetylcholine receptor subunit alpha-7
External Links
UniProt	P49582
EMBL	L37663
CCDS	CCDS21329.1
PIR	A57175
RefSeq	NP_031416.3
UniGene	Mm.113464
ProteinModelPortal	P49582
SMR	P49582
BioGrid	197934
DIP	DIP-48732N
BindingDB	P49582
ChEMBL	CHEMBL3365
GuidetoPHARMACOLOGY	468
PhosphoSite	P49582
PRIDE	P49582
Ensembl	ENSMUST00000032738
GeneID	11441
KEGG	mmu:11441
UCSC	uc009vel.1
CTD	1139
MGI	MGI:99779
eggNOG	NOG235631
HOGENOM	HOG000006756
HOVERGEN	HBG003756
InParanoid	P49582
KO	K04809
OMA	NLLHSGH
OrthoDB	EOG72JWGV
PhylomeDB	P49582
TreeFam	TF315605
Reactome	REACT_198583
NextBio	278744
PRO	PR:P49582
Proteomes	UP000000589
Bgee	P49582
ExpressionAtlas	P49582
Genevestigator	P49582
GO	GO:0005892 GO:0016324 GO:0032279 GO:0030424 GO:0030054 GO:0005737 GO:0043198 GO:0043197 GO:0009897 GO:0030426 GO:0016020 GO:0045121 GO:0043025 GO:0014069 GO:0045211 GO:0042734 GO:0042166 GO:0004889 GO:0008144 GO:0008306 GO:0042113 GO:0048149 GO:0035095 GO:0006816 GO:0098655 GO:0042416 GO:0006897 GO:0060112 GO:0006811 GO:0007613 GO:0050728 GO:0032691 GO:0032715 GO:0032720 GO:0019228 GO:0042698 GO:0001988 GO:0050727 GO:0042391 GO:0014061 GO:0032225 GO:0045471 GO:0032094 GO:0035094 GO:0030317 GO:0007271 GO:0042110
Gene3D	1.20.120.370 2.70.170.10
InterPro	IPR027361 IPR006202 IPR006201 IPR006029 IPR018000 IPR002394
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR00254 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050728	negative regulation of inflammatory response	PMID:24454942^[1]	ECO:0000314			P		Fig. 8C shows administration of GTS-21, specific agonist of α7nAchR, significantly reduces FA occurrence.	complete CACAO 9385
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19230830^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P49841) occurs_in:(UBERON:0003027)\|has_regulation_target(UniProtKB:P49841) occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:17898229^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0003027)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:17898229^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0003027) regulates_o_occurs_in:(GO:0043005)\|occurs_in(UBERON:0001885) regulates_o_occurs_in:(GO:0043005)	Seeded From UniProt	complete
involved_in	GO:0050893	sensory processing	PMID:17898229^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:19118188^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P05067:PRO_0000000092	P	occurs_in:(UBERON:0002421) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:19118188^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P05067:PRO_0000000092	P	occurs_in:(UBERON:0002421) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:19118188^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P05067:PRO_0000000092	P	occurs_in:(UBERON:0002421) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	PMID:19118188^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421) regulates:(GO:0060291)\|occurs_in(UBERON:0002421) regulates:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905920	positive regulation of CoA-transferase activity	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:Q03059)\|has_input(UniProtKB:P12023) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002743) has_regulation_target:(UniProtKB:Q03059)	Seeded From UniProt	complete
involved_in	GO:0032222	regulation of synaptic transmission, cholinergic	PMID:20164328^[5]	ECO:0000305	curator inference used in manual assertion	GO:0051247	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:Q03059)\|has_input(UniProtKB:P12023) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002743) has_regulation_target:(UniProtKB:Q03059)	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:19587288^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	occurs_in:(UBERON:0001870) happens_during:(UBERON:0007222) has_input:(UniProtKB:P12023)\|occurs_in(UBERON:0002421) happens_during:(UBERON:0007222) has_input:(UniProtKB:P12023)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:19587288^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0007222)	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:19230830^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:19230830^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10637) occurs_in:(UBERON:0000955) regulates:(GO:0009409)	Seeded From UniProt	complete
involved_in	GO:1901214	regulation of neuron death	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241) regulates_o_occurs_in:(CL:1001571)\|has_input(UniProtKB:P12023) happens_during:(UBERON:0018241) regulates_o_occurs_in:(CL:0001033)	Seeded From UniProt	complete
involved_in	GO:0051823	regulation of synapse structural plasticity	PMID:20164328^[5]	ECO:0000305	curator inference used in manual assertion	GO:0051247	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P20357)	Seeded From UniProt	complete
involved_in	GO:1905906	regulation of amyloid fibril formation	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:1905923	positive regulation of acetylcholine biosynthetic process	PMID:20164328^[5]	ECO:0000305	curator inference used in manual assertion	GO:0051247,GO:1905920	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:20943921^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P56818	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:20974225^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:20164328^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_output:(UniProtKB:P05067:PRO_0000000093) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)\|has_output(UniProtKB:P05067:PRO_0000000093) happens_during:(UBERON:0007222) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)\|has_output(UniProtKB:P05067:PRO_0000000092) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)\|has_output(UniProtKB:P05067:PRO_0000000092) happens_during:(UBERON:0007222) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:0140059	dendrite arborization	PMID:23270857^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0035874)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:20974225^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0097061	dendritic spine organization	PMID:23270857^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881) occurs_in:(CL:0002608) occurs_in:(GO:0098794)	Seeded From UniProt	complete
involved_in	GO:0098815	modulation of excitatory postsynaptic potential	PMID:20974225^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0098815	modulation of excitatory postsynaptic potential	PMID:20974225^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:11404397^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0035094) has_regulation_target:(UniProtKB:P63085)	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:11404397^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P63085	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	PMID:12079404^[11]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098981) part_of:(UBERON:0000061) part_of:(UBERON:0001989)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:24607281^[12]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:24607281^[12]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:24607281^[12]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:24607281^[12]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	PMID:12079404^[11]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0001989)	Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 RGD:2348 UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P		Seeded From UniProt	complete
contributes_to	GO:0015464	acetylcholine receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0007271	synaptic transmission, cholinergic	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99779 PANTHER:PTN001450553 RGD:2348	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 RGD:2348 UniProtKB:P36544	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C		Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905144	response to acetylcholine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905144	response to acetylcholine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902991	regulation of amyloid precursor protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902430	negative regulation of amyloid-beta formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
part_of	GO:0099065	integral component of spine apparatus membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0098690	glycinergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0095500	acetylcholine receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060112	generation of ovulation cycle rhythm	PMID:15364017^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050893	sensory processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050890	cognition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	PMID:16785311^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:12508119^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048149	behavioral response to ethanol	PMID:15489024^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	PMID:15555774^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042698	ovulation cycle	PMID:1400473^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:9364063^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:10800961^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05941	P		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042113	B cell activation	PMID:16253349^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042113	B cell activation	PMID:15963492^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042110	T cell activation	PMID:16253349^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035095	behavioral response to nicotine	PMID:17470777^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	PMID:9495872^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	PMID:17291692^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035094	response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034220	ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	PMID:16785311^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P	regulates_o_occurs_in:(EMAPA:18767)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	PMID:12508119^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032715	negative regulation of interleukin-6 production	PMID:12508119^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032691	negative regulation of interleukin-1 beta production	PMID:12508119^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
part_of	GO:0032279	asymmetric synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032225	regulation of synaptic transmission, dopaminergic	PMID:16772172^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P	regulates_o_has_participant:(EMAPA:35914) regulates_o_has_participant:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032094	response to food	PMID:15922075^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
part_of	GO:0030673	axolemma	PMID:18458158^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000101)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030317	flagellated sperm motility	PMID:15944242^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P	results_in_movement_of:(CL:0000019)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:9364063^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	F	occurs_in:(EMAPA:32845)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:9037516^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(EMAPA:32845)\|occurs_in:(EMAPA:17536)\|occurs_in:(EMAPA:36556)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:11834293^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	F	occurs_in:(EMAPA:32869)\|occurs_in:(EMAPA:17544)\|occurs_in:(EMAPA:32845)\|occurs_in:(EMAPA:19095)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:9495872^[25]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:36556)\|occurs_in:(EMAPA:32845)\|occurs_in:(EMAPA:17536)\|occurs_in:(EMAPA:17549)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05941	F		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019228	neuronal action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
enables	GO:0017081	chloride channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:16033766^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17663) part_of:(CL:0000082)\|part_of:(EMAPA:17663) part_of:(CL:0000158)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19246390^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11834293^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0015643	toxic substance binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
enables	GO:0015464	acetylcholine receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014061	regulation of norepinephrine secretion	PMID:10942027^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P	regulates_o_occurs_in:(EMAPA:16688) regulates_o_occurs_in:(CL:0000540)\|regulates_o_occurs_in:(EMAPA:16985) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15963492^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18767) part_of:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	PMID:15541879^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87891	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	PMID:15922075^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
enables	GO:0008179	adenylate cyclase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:16923147^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007271	synaptic transmission, cholinergic	PMID:9364063^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007271	synaptic transmission, cholinergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006897	endocytosis	PMID:16025111^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006811	ion transport	PMID:9364063^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006811	ion transport	PMID:10800961^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155604	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	C		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2348	C		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001988	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	PMID:10942027^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888407	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1904315	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	C		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:19118188^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yamamoto, T et al. (2014) Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS ONE 9 e85888 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Bitner, RS et al. (2009) Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. Brain Res. 1265 65-74 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bitner, RS et al. (2007) Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J. Neurosci. 27 10578-87 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Puzzo, D et al. (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 14537-45 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Hernandez, CM et al. (2010) Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J. Neurosci. 30 2442-53 PubMed GONUTS page
↑ ^6.0 ^6.1 Dziewczapolski, G et al. (2009) Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J. Neurosci. 29 8805-15 PubMed GONUTS page
↑ Wang, H et al. (2010) Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors. J. Neurosci. 30 13808-13 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Söderman, A et al. (2011) Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1ΔE9 mice. Neurosci. Lett. 487 325-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Morley, BJ & Mervis, RF (2013) Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice. Neuroscience 233 54-63 PubMed GONUTS page
↑ ^10.0 ^10.1 Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page
↑ ^11.0 ^11.1 Del Signore, A et al. (2002) Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion. Neurobiol. Dis. 10 54-66 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Garção, P et al. (2014) Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neurosci. Lett. 566 106-10 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Morley, BJ & Rodriguez-Sierra, JF (2004) A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant. Brain Res. 1023 41-7 PubMed GONUTS page
↑ ^15.0 ^15.1 Huston, JM et al. (2006) Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J. Exp. Med. 203 1623-8 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Wang, H et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421 384-8 PubMed GONUTS page
↑ Wehner, JM et al. (2004) Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience 129 11-24 PubMed GONUTS page
↑ de Fiebre, NC & de Fiebre, CM (2005) alpha7 Nicotinic acetylcholine receptor knockout selectively enhances ethanol-, but not beta-amyloid-induced neurotoxicity. Neurosci. Lett. 373 42-7 PubMed GONUTS page
↑ Schultz, JR et al. (1992) Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice. J. Biol. Chem. 267 21630-6 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Orr-Urtreger, A et al. (1997) Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J. Neurosci. 17 9165-71 PubMed GONUTS page
↑ ^21.0 ^21.1 Orr-Urtreger, A et al. (2000) Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J. Neurochem. 74 2154-66 PubMed GONUTS page
↑ ^22.0 ^22.1 Skok, M et al. (2006) The role of nicotinic acetylcholine receptors in lymphocyte development. J. Neuroimmunol. 171 86-98 PubMed GONUTS page
↑ ^23.0 ^23.1 Skok, M et al. (2005) Nicotinic receptors regulate B lymphocyte activation and immune response. Eur. J. Pharmacol. 517 246-51 PubMed GONUTS page
↑ Besson, M et al. (2007) Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proc. Natl. Acad. Sci. U.S.A. 104 8155-60 PubMed GONUTS page
↑ ^25.0 ^25.1 Stitzel, JA et al. (1998) Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes. J. Pharmacol. Exp. Ther. 284 1104-11 PubMed GONUTS page
↑ Egea, J et al. (2007) Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice. Neuroscience 145 866-72 PubMed GONUTS page
↑ Mameli-Engvall, M et al. (2006) Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors. Neuron 50 911-21 PubMed GONUTS page
↑ ^28.0 ^28.1 Keller, JJ et al. (2005) Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task. Behav. Brain Res. 162 143-52 PubMed GONUTS page
↑ Hancock, ML et al. (2008) Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons. J. Cell Biol. 181 511-21 PubMed GONUTS page
↑ Bray, C et al. (2005) Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility. Biol. Reprod. 73 807-14 PubMed GONUTS page
↑ Stitzel, JA et al. (1996) Linkage of strain-specific nicotinic receptor alpha 7 subunit restriction fragment length polymorphisms with levels of alpha-bungarotoxin binding in brain. Brain Res. Mol. Brain Res. 43 30-40 PubMed GONUTS page
↑ ^32.0 ^32.1 Franceschini, D et al. (2002) Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Brain Res. Mol. Brain Res. 98 29-40 PubMed GONUTS page
↑ Reynolds, PR & Hoidal, JR (2005) Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development. J. Biol. Chem. 280 32548-54 PubMed GONUTS page
↑ Tekinay, AB et al. (2009) A role for LYNX2 in anxiety-related behavior. Proc. Natl. Acad. Sci. U.S.A. 106 4477-82 PubMed GONUTS page
↑ ^35.0 ^35.1 Franceschini, D et al. (2000) Altered baroreflex responses in alpha7 deficient mice. Behav. Brain Res. 113 3-10 PubMed GONUTS page
↑ Marubio, LM & Paylor, R (2004) Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors. Neuroscience 129 575-82 PubMed GONUTS page
↑ Fernandes, C et al. (2006) Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav. 5 433-40 PubMed GONUTS page
↑ Snyder, EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8 1051-8 PubMed GONUTS page

[PMID:24454942-1] Yamamoto, T et al. (2014) Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS ONE 9 e85888 PubMed GONUTS page

[PMID:19230830-2] 2.0 ^2.1 ^2.2 Bitner, RS et al. (2009) Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. Brain Res. 1265 65-74 PubMed GONUTS page

[PMID:17898229-3] 3.0 ^3.1 ^3.2 Bitner, RS et al. (2007) Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J. Neurosci. 27 10578-87 PubMed GONUTS page

[PMID:19118188-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Puzzo, D et al. (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 14537-45 PubMed GONUTS page

[PMID:20164328-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Hernandez, CM et al. (2010) Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J. Neurosci. 30 2442-53 PubMed GONUTS page

[PMID:19587288-6] 6.0 ^6.1 Dziewczapolski, G et al. (2009) Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J. Neurosci. 29 8805-15 PubMed GONUTS page

[PMID:20943921-7] Wang, H et al. (2010) Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors. J. Neurosci. 30 13808-13 PubMed GONUTS page

[PMID:20974225-8] 8.0 ^8.1 ^8.2 ^8.3 Söderman, A et al. (2011) Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1ΔE9 mice. Neurosci. Lett. 487 325-9 PubMed GONUTS page

[PMID:23270857-9] 9.0 ^9.1 Morley, BJ & Mervis, RF (2013) Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice. Neuroscience 233 54-63 PubMed GONUTS page

[PMID:11404397-10] 10.0 ^10.1 Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page

[PMID:12079404-11] 11.0 ^11.1 Del Signore, A et al. (2002) Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion. Neurobiol. Dis. 10 54-66 PubMed GONUTS page

[PMID:24607281-12] 12.0 ^12.1 ^12.2 ^12.3 Garção, P et al. (2014) Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neurosci. Lett. 566 106-10 PubMed GONUTS page

[PMID:21873635-13] 13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15364017-14] Morley, BJ & Rodriguez-Sierra, JF (2004) A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant. Brain Res. 1023 41-7 PubMed GONUTS page

[PMID:16785311-15] 15.0 ^15.1 Huston, JM et al. (2006) Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J. Exp. Med. 203 1623-8 PubMed GONUTS page

[PMID:12508119-16] 16.0 ^16.1 ^16.2 ^16.3 Wang, H et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421 384-8 PubMed GONUTS page

[PMID:15489024-17] Wehner, JM et al. (2004) Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience 129 11-24 PubMed GONUTS page

[PMID:15555774-18] Fiebre, NC & de Fiebre, CM (2005) alpha7 Nicotinic acetylcholine receptor knockout selectively enhances ethanol-, but not beta-amyloid-induced neurotoxicity. Neurosci. Lett. 373 42-7 PubMed GONUTS page

[PMID:1400473-19] Schultz, JR et al. (1992) Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice. J. Biol. Chem. 267 21630-6 PubMed GONUTS page

[PMID:9364063-20] 20.0 ^20.1 ^20.2 ^20.3 Orr-Urtreger, A et al. (1997) Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J. Neurosci. 17 9165-71 PubMed GONUTS page

[PMID:10800961-21] 21.0 ^21.1 Orr-Urtreger, A et al. (2000) Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J. Neurochem. 74 2154-66 PubMed GONUTS page

[PMID:16253349-22] 22.0 ^22.1 Skok, M et al. (2006) The role of nicotinic acetylcholine receptors in lymphocyte development. J. Neuroimmunol. 171 86-98 PubMed GONUTS page

[PMID:15963492-23] 23.0 ^23.1 Skok, M et al. (2005) Nicotinic receptors regulate B lymphocyte activation and immune response. Eur. J. Pharmacol. 517 246-51 PubMed GONUTS page

[PMID:17470777-24] Besson, M et al. (2007) Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proc. Natl. Acad. Sci. U.S.A. 104 8155-60 PubMed GONUTS page

[PMID:9495872-25] 25.0 ^25.1 Stitzel, JA et al. (1998) Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes. J. Pharmacol. Exp. Ther. 284 1104-11 PubMed GONUTS page

[PMID:17291692-26] Egea, J et al. (2007) Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice. Neuroscience 145 866-72 PubMed GONUTS page

[PMID:16772172-27] Mameli-Engvall, M et al. (2006) Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors. Neuron 50 911-21 PubMed GONUTS page

[PMID:15922075-28] 28.0 ^28.1 Keller, JJ et al. (2005) Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task. Behav. Brain Res. 162 143-52 PubMed GONUTS page

[PMID:18458158-29] Hancock, ML et al. (2008) Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons. J. Cell Biol. 181 511-21 PubMed GONUTS page

[PMID:15944242-30] Bray, C et al. (2005) Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility. Biol. Reprod. 73 807-14 PubMed GONUTS page

[PMID:9037516-31] Stitzel, JA et al. (1996) Linkage of strain-specific nicotinic receptor alpha 7 subunit restriction fragment length polymorphisms with levels of alpha-bungarotoxin binding in brain. Brain Res. Mol. Brain Res. 43 30-40 PubMed GONUTS page

[PMID:11834293-32] 32.0 ^32.1 Franceschini, D et al. (2002) Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Brain Res. Mol. Brain Res. 98 29-40 PubMed GONUTS page

[PMID:16033766-33] Reynolds, PR & Hoidal, JR (2005) Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development. J. Biol. Chem. 280 32548-54 PubMed GONUTS page

[PMID:19246390-34] Tekinay, AB et al. (2009) A role for LYNX2 in anxiety-related behavior. Proc. Natl. Acad. Sci. U.S.A. 106 4477-82 PubMed GONUTS page

[PMID:10942027-35] 35.0 ^35.1 Franceschini, D et al. (2000) Altered baroreflex responses in alpha7 deficient mice. Behav. Brain Res. 113 3-10 PubMed GONUTS page

[PMID:15541879-36] Marubio, LM & Paylor, R (2004) Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors. Neuroscience 129 575-82 PubMed GONUTS page

[PMID:16923147-37] Fernandes, C et al. (2006) Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav. 5 433-40 PubMed GONUTS page

[PMID:16025111-38] Snyder, EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8 1051-8 PubMed GONUTS page

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