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PMID:16253349

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Citation

Skok, M, Grailhe, R, Agenes, F and Changeux, JP (2006) The role of nicotinic acetylcholine receptors in lymphocyte development. J. Neuroimmunol. 171:86-98

Abstract

The sizes of lymphocyte populations in lymphoid organs of nicotinic acetylcholine receptor knockout and chimera (knockout/wild-type) mice were studied by flow cytometry. The absence of beta2 subunit decreased, while nicotine treatment increased B lymphocyte numbers in the bone marrow. In chimera mice, either beta2 or alpha7 subunits influenced lymphocyte populations in primary lymphoid organs, while in the spleen, only alpha7 receptors were critical. More annexin V-positive B cells were found in the bone marrow of knockout than wild-type animals. We conclude that nicotinic receptors are involved in regulating lymphocyte development and control the B lymphocyte survival.

Links

PubMed Online version:10.1016/j.jneuroim.2005.09.011

Keywords

Animals; Antigens, CD/metabolism; Behavior, Animal; Bone Marrow Transplantation/methods; Cell Count/methods; Cell Growth Processes/physiology; Flow Cytometry/methods; Gene Expression Regulation, Developmental/genetics; Gene Expression Regulation, Developmental/physiology; Lymphocytes/classification; Lymphocytes/physiology; Male; Mice; Mice, Knockout; Nicotine/pharmacology; Nicotinic Agonists/pharmacology; Radiation Chimera/physiology; Receptors, Nicotinic/deficiency; Receptors, Nicotinic/physiology; Spleen/metabolism; Spleen/radiation effects; Thymic Factor, Circulating/metabolism; Thymic Factor, Circulating/radiation effects

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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References

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