PMID:15541879

Citation	Marubio, LM and Paylor, R (2004) Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors. Neuroscience 129:575-82
Abstract	The nicotinic cholinergic system influences cognition, anxiety, locomotion, and addiction by acting upon nicotinic acetylcholine receptors (nAChRs). To date, there are 12 known neuronal mammalian nAChR subunits leading to a rich pharmacological diversity that is difficult to attribute to specific subunits. We generated alpha7-beta2 nAChR double mutant mice by breeding to investigate the effect of a minimal number of nAChRs in the CNS. These mice have been used to determine the role these receptor subunits play in a variety of behaviors. A battery of behavioral tests was used to determine the effect of the mutation in anxiety, locomotor activity, startle response, pre-pulse inhibition, motor coordination and learning and memory. Mice lacking both the alpha7 and the beta2 nAChR subunits displayed impaired learning and memory performance in a passive avoidance test and showed enhanced motor performance on the rotarod.
Links	PubMed Online version:10.1016/j.neuroscience.2004.09.003
Keywords	Analysis of Variance; Animals; Avoidance Learning/physiology; Behavior, Animal; Brain/cytology; Exploratory Behavior/physiology; Inhibition (Psychology); Male; Mice; Mice, Knockout; Motor Activity/genetics; Neurons/metabolism; Protein Subunits/deficiency; Protein Subunits/genetics; Psychomotor Performance/physiology; Receptors, Nicotinic/deficiency; Receptors, Nicotinic/genetics; Receptors, Nicotinic/physiology; Reflex, Acoustic/physiology
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